Ş. Güniz Küçükgüzel - Publications, H-index & Citations

Ş. Güniz Küçükgüzel

Fenerbahce University

31H指数

96论文数

5.2K被引数

收录论文 35

发表时间

Ibuprofen and nimesulide derivatives selectively induce apoptosis in HER2-positive breast cancer via inhibition of the PLA₂–COX-2–NF-κB pathway 布洛芬和尼美舒利衍生物通过抑制PLA₂–COX-2–NF-κB通路选择性诱导HER2阳性乳腺癌细胞凋亡

Molecular Biology Reports

IF2.8

2026-04-24

OAAI

Egemen Çakırlı; İpek Bedir; Yağmur Biliz; Özgür Yılmaz; Ş. Güniz Küçükgüzel; Dilek Telci

Novel hydrazide-hydrazone derivatives containing flurbiprofen 1,2,4-triazole as anticancer agents: design, synthesis and biological evaluation 含氟比洛芬1,2,4-三唑的酰肼-腙衍生物作为抗癌剂：设计、合成与生物评价

Acta Chimica Slovenica

IF1.3

2026-01-01

PREAI

Gokoglan, Ecem; Cakici, Cigdem; Erdogan, Omer; Yilmaz, Ozgur; Cevik, Ozge; Kucukguzel, S. Guniz

New diclofenac hydrazones: Design, synthesis, in silico studies and anticancer evaluation against breast cancer 新型双氯芬酸腙衍生物：设计、合成、计算机模拟研究及对乳腺癌的抗癌活性评价

Journal of Molecular Structure

IF4.7

2025-11-14

PREAI

Kaan Birgül; Lalehan Oktay; Hatice Bekci; Pelin Çıkla-Süzgün; Serdar Durdağı; Ş. Güniz Küçükgüzel

Biological Activities of Etodolac-Based Hydrazone, Thiazolidinone and Triazole Derivatives on Breast Cancer Cell Lines MCF-7 and MDA-MB-231 依托多拉克基 hydrazone、thiazolidinone 和 triazole 衍生物的生物活性研究：在人乳腺癌细胞系 MCF-7 和 MDA-MB-231 上的作用

Journal of Biochemical and Molecular Toxicology

IF2.8

2025-08-11

OAAI

Sevgi Kocyigit Sevinc; Pelin Çıkla-Süzgün; Pinar Mega Tiber; Ş. Güniz Küçükgüzel; Oya Orun

Investigation of novel nimesulide derivatives against breast cancer 新型尼美舒利衍生物抗乳腺癌的研究

Bioorganic Chemistry

IF4.7

2025-08-06

PREAI

Kaan Birgül; İrem Atlıhan; Damla Dere; Kemal Yelekçi; Pinar Mega Tiber; Oya Orun; Ş. Güniz Küçükgüzel

Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors 以布洛芬为原料设计合成噻唑脲类衍生物和1,2,4-三唑类衍生物作为潜在的MetAP (II型) 抑制剂

CHEMICO-BIOLOGICAL INTERACTIONS

IF5.4

2025-05-27

PREAI

Yilmaz, Ozgur; Biliz, Yagmur; Ayan, Sumeyra; Cevik, Ozge; Karahasanoglu, Mufide; Cotuker, Reyhan; Sahin, Naz Mina Mert; Gokkaya, Kubra; Gulyuz, Sevgi; Yelekci, Kemal; Kucukguzel, S. . Guniz

A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery

MACROMOLECULAR BIOSCIENCE

IF4.1

2023-10-22

OAAI

Gulyuz, Sevgi; Sessevmez, Melike; Ukuser, Gokcen; Khalily, Melek Parlak; Tiryaki, Selen; Sipahioglu, Tarik; Birgul, Kaan; Omeroglu, Ipek; Ozcubukcu, Salih; Telci, Dilek; Kucukguzel, S. Guniz; Durmus, Mahmut; Cevher, Erdal; Yilmaz, Ozgur

Synthesis and investigation of cytotoxic effects of compounds derived from flurbiprofen

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2023-10-01

PREAI

Gokoglan, Ecem; Dere, Damla; Bedir, Ipek; Yelekci, Kemal; Telci, Dilek; Kucukguzel, S. Guniz

Synthesis, antimicrobial evaluation and molecular modeling studies of novel thiosemicarbazides/semicarbazides derived from p-aminobenzoic acid

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2022-08-01

PREAI

Han, M. Ihsan; Ince, Ufuk; Gunduz, Miyase Gozde; Coskun, G. Pelin; Birgul, Kaan; Dogan, Senguel Dilem; Kucukguzel, S. Guniz

Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2022-07-01

PREAI

Birgul, Kaan; Uba, Abdullah Ibrahim; Cuhadar, Ozan; Sevinc, Sevgi Kocyigit; Tiryaki, Selen; Tiber, Pinar Mega; Orun, Oya; Telci, Dilek; Yilmaz, Ozgur; Yelekci, Kemal; Kucukguzel, S. Guniz

Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2021-05-01

PREAI

Han, M. Ihsan; Atalay, Pinar; Tunc, Cansu Umran; Unal, Gokhan; Dayan, Serkan; Aydin, Omer; Kucukguzel, S. Guniz

Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer

AMINO ACIDS

IF2.4

2021-04-13

PREAI

Nezir, Ayca Ece; Khalily, Melek Parlak; Gulyuz, Sevgi; Ozcubukcu, Salih; Kucukguzel, S. Guniz; Yilmaz, Ozgur; Telci, Dilek

Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis

JOURNAL OF MOLECULAR STRUCTURE

IF4.7

2021-01-01

PREAI

Senkardes, Sevil; Ture, Asli; Ekrek, Sedanur; Durak, Asim Tugrul; Abbak, Muruvvet; Cevik, Ozge; Kaskatepe, Banu; Kucukguzel, Ilkay; Kucukguzel, S. Guniz

Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (thorn) (S)-naproxen derivatives

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-12-01

PREAI

Birgul, Kaan; Yildirim, Yeliz; Karasulu, H. Yesim; Karasulu, Ercument; Uba, Abdullah Ibrahim; Yelekci, Kemal; Bekci, Hatice; Cumaoglu, Ahmet; Kabasakal, Levent; Yilmaz, Ozgur; Kucukguzel, S. Guniz

Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives

MINI-REVIEWS IN MEDICINAL CHEMISTRY

IF3.3

2020-08-20

PREAI

Han, M. Ihsan; Kucukguzel, S. Guniz

Recent Advances in Apoptosis: The Role of Hydrazones

MINI-REVIEWS IN MEDICINAL CHEMISTRY

IF3.3

2019-09-25

PREAI

Cikla-Suzgun, Pelin; Kucukguzel, S. Guniz