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Christophe Pannecouque

ku leuven

71H指数
757论文数
2.0W被引数
收录论文 354
发表时间
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Surface Plasmon Resonance as a Potential Diagnostic Tool for the Detection of CXC Chemokine Receptor 4 (CXCR4) on Extracellular Vesicles表面等离激元共振作为检测细胞外囊泡上CXC趋化因子受体4（CXCR4）的潜在诊断工具
errBiosensors
IF5.6
err2026-03-28
err0
errOAAI
errKaat Verleye; Sam Noppen; Arnaud Boonen; Yagmur Yildizhan; Tom Van Loy; Cindy Heens; Frank Vanderhoydonc; Cláudio Pinheiro; Paula M. Pincela Lins; Annelies Bronckaers; An Hendrix; Johannes V. Swinnen; Dragana Spasic; Jeroen Lammertyn; Christophe Pannecouque; Dominique Schols
err分享
err收藏
Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence基于药效团导向生成式人工智能的广谱非核苷类逆转录酶抑制剂理性设计
errJournal of Medicinal Chemistry
IF6.8
err2026-03-01
err1
PREAI
errZhang, Kun; Lin, Yuhan; Dong, Ling; Niu, Yuting; Peng, Jian; Pannecouque, Christophe; De Clercq, Erik; Tran, Phuong-Thao; Li, Guobo; Zhao, Tiancong; Li, Xudong; Su, Shuo; Wang, Shuai; Chen, Fen-Er
err分享
err收藏
Discovery of novel diarylpyrimidine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors: Design, synthesis and biological activity evaluation
errBioorganic Chemistry
IF4.7
err2026-01-04
err0
PREAI
errHao Lin; Zhongxia Zhou; Lin Zheng; Ying Liu; Da Feng; Xiangyi Jiang; Yanying Sun; Xiangkai Ji; Erik De Clercq; Christophe Pannecouque; Chin-Ho Chen; Dongwei Kang; Peng Zhan; Xinyong Liu
err分享
err收藏
Coumarin-stavudine (d4T) novel hybrid ProTides with dual-functionality and enhanced anti-HIV activity香豆素-司他夫定（d4T）具有双功能和增强抗HIV活性的新型ProTides杂化物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-12-30
err0
errOAAI
errSahar B. Kandil; Katie S. Jones; Christophe Pannecouque; Andrew D. Westwell
err分享
err收藏
Correction to “Exploring the HIV-1 Reverse Transcriptase p51/p66 Interface: Structure-Based Design and Optimization of Novel 2; 4; 6-Trisubstituted Pyrimidines as Potent NNRTIs with Improved Resistance Profiles”“对《探索HIV-1逆转录酶p51/p66界面：基于结构的2; 4; 6-三取代嘧啶类新型非核苷逆转录酶抑制剂的设计与优化及其改进的抗药性谱》的更正”
errJournal of Medicinal Chemistry
IF6.8
err2025-10-23
err0
errOAAI
errXiangkai Ji; Xiangyi Jiang; Zhen Gao; Heng Gao; Xing Huang; Fabao Zhao; Erik De Clercq; Zhao Wang; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
err分享
err收藏
Structure- and Privileged Fragment-Based Iterative Optimization: Discovery of 2,4-Disubstituted-6-aminopyrimidines as Novel HIV-1 NNRTIs with Potent Activity against Drug-Resistant Strains and Favorable Safety Profiles基于结构和特权片段的迭代优化: 发现2，4-二取代-6-氨基嘧啶作为新型HIV-1 nnrti，对耐药菌株具有有效活性和良好的安全性
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-10-01
err0
PREAI
errJi, Xiangkai; Jiang, Xiangyi; Gao, Heng; Gao, Zhen; De Clercq, Erik; Pannecouque, Christophe; Kang, Dongwei; Zhan, Peng; Liu, Xinyong
err分享
err收藏
Design, synthesis, and biological evaluation of dual-site HIV-1 inhibitors simultaneously targeting the NNRTI binding pocket and an adjacent site with favorable resistance profiles双位点HIV-1抑制剂的分子设计、合成及其生物活性评价：同时靶向NNRTI结合口袋及相邻位点，并表现出有利的耐药性谱。
errBioorganic Chemistry
IF4.7
err2025-08-26
err0
PREAI
errXiangkai Ji; Xiangyi Jiang; Xing Huang; Heng Gao; Zhen Gao; Ping Gao; Erik De Clercq; Christophe Pannecouque; Dongwei Kang; Peng Zhan; Xinyong Liu
err分享
err收藏
Halogenation-Driven Discovery of Halomethylene-Biphenyl-Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Improved Safety and PK Profiles卤代作用驱动的卤代亚甲基-联苯-二芳基嘧啶类化合物作为具有改善安全性和药代动力学特性的强效HIV-1非核苷类逆转录酶抑制剂的开发
errJournal of Medicinal Chemistry
IF6.8
err2025-07-26
err0
PREAI
errXiao-Mei Chen; Qian Xu; Christophe Pannecouque; Erik De Clercq; Enzo Tramontano; Phuong-Thao Tran; Shuai Wang; Fen-Er Chen
err分享
err收藏
Further exploring the tolerant region II: Identification of 2,4,5-trisubstituted pyrimidines as HIV-1 reverse transcriptase allosteric inhibitors with desirable antiviral activities and reduced cytotoxicity进一步探索耐受区域II：鉴定2,4,5-三取代嘧啶类作为具有理想抗病毒活性和降低细胞毒性的HIV-1逆转录酶别构抑制剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-07-21
err0
PREAI
errZhenzhen Zhou; Lin Zheng; Wenbo Jiang; Wenbo Zhang; Fabao Zhao; Zhening Liang; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Dongwei Kang; Xinyong Liu
err分享
err收藏
Probing the Dominant Motifs within the Hydrophobic Channel Yields Oxadiazole-Containing Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors探查疏水通道中的优势基序产生含恶二唑的二芳基嘧啶衍生物，作为强效HIV-1非核苷类逆转录酶抑制剂
errJournal of Medicinal Chemistry
IF6.8
err2025-07-17
err0
PREAI
errTao Zhang; Yue Yang; Xin Li; Fabao Zhao; Zongji Zhuo; Le Wang; Wenbo Zhang; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Dongwei Kang; Xinyong Liu
err分享
err收藏
Bioisosterism-driven design of orally active, safe, and broad-spectrum biphenyl-DAPY derivatives as highly potent HIV-1 non-nucleoside reverse transcriptase inhibitors生物等排体驱动的口服活性、安全且广谱的二苯基-DAPY衍生物的设计，作为高活性HIV-1非核苷类反转录酶抑制剂
errActa Pharmaceutica Sinica B
IF14.6
err2025-06-24
err0
errOAAI
errXiao-Mei Chen; Qing-Qing Hao; Christophe Pannecouque; Erik De Clercq; Shuai Wang; Fen-Er Chen
err分享
err收藏
Rational structure-based design and optimization of next-generation biphenyl-piperidine-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors基于结构的理性设计和对下一代联苯-哌啶-三嗪衍生物的优化，作为强效非核苷类逆转录酶抑制剂
errChinese Chemical Letters
IF8.9
err2025-05-21
err0
PREAI
errKun Zhang; Li-Min Zhao; Tianhao Xing; Yueyue Bu; Qingyun Wang; Christophe Pannecouque; Erik De Clercq; Angela Corona; Laura Dettori; Enzo Tramontano; Shuai Wang; Fen-Er Chen
err分享
err收藏
Design, Synthesis and Biological Evaluation of 3-Hydrazonoindolin-2-one Derivatives as Novel HIV-1 RNase H Inhibitors3-肼基酮基吲哚啉-2-酮衍生物的设计、合成及生物评价：作为新型HIV-1 RNase H抑制剂的探索
errMOLECULES
IF4.6
err2025-04-22
err0
errOAAI
errZhang, Yiying; Wang, Rao; Bu, Yueyue; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Pannecouque, Christophe; De Clercq, Erik; Meng, Ge; Chen, Fen-Er
err分享
err收藏
Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability氘代策略启发的新型 Diarylpyrimidine 衍生物的设计，作为高效的非核苷类逆转录酶抑制剂，具有提高的疗效、选择性和成药性
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-05
err0
PREAI
errZhang, Kun; Xing, Tianhao; Ding, Li; Pannecouque, Christophe; De Clercq, Erik; Dettori, Laura; Tramontano, Enzo; Chen, Fen-Er
err分享
err收藏
Structure-based discovery of novel diarylpyrimidines as potent and selective Non-Nucleoside reverse transcriptase inhibitors: From CH (CN)-Biphenyl-Diarylpyrimidines to C.905em-1NNH2-Biphenyl- Diarylpyrimidines
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-03-01
err0
PREAI
errChen, Xiao-Mei; Pannecouque, Christophe; De Clercq, Erik; Lian, Yu-Xuan; Corona, Angela; Dettori, Laura; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
err分享
err收藏
Structure-based design of novel 2,4,5-trisubstituted pyrimidine derivatives as potent HIV-1 NNRTIs by exploiting the tolerant regions in NNTRIs binding pocket
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-02-01
err0
PREAI
errZhou, Zhenzhen; Xie, Minghui; Zhuo, Zongji; Wang, Yalin; Zhao, Fabao; Tao, Sining; Liang, Zhening; De Clercq, Erik; Pannecouque, Christophe; Zhan, Peng; Kang, Dongwei; Liu, Xinyong
err分享
err收藏
Discovery of novel fused-heterocycle-bearing diarypyrimidine derivatives as HIV-1 potent NNRTIs targeting tolerant region I for enhanced antiviral activity and resistance profile
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-01-01
err1
PREAI
errDai, Jiaojiao; Jiang, Xiangyi; Gao, Heng; Huang, Boshi; De Clercq, Erik; Pannecouque, Christophe; Du, Shaoqing; Liu, Xinyong; Zhan, Peng
err分享
err收藏
Rapid identification of novel indolylarylsulfone derivatives as potent HIV-1 NNRTIs via miniaturized CuAAC click-chemistry-based combinatorial libraries
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err0
PREAI
errGao, Ping; Song, Shu; Pannecouque, Christophe; De Clercq, Erik; Zhan, Peng; Liu, Xinyong
err分享
err收藏
Identification of novel diarylpyrimidine derivatives as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against wild-type and K103N mutant viruses
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err1
PREAI
errJiang, Xiangyi; Zalloum, Waleed A.; Gao, Zhen; Dai, Jiaojiao; Ji, Xiangkai; Xie, Minghui; Dong, Guanyu; De Clercq, Erik; Huang, Boshi; Pannecouque, Christophe; Zhan, Peng; Liu, Xinyong
err分享
err收藏
Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-05
err0
PREAI
errHuang, Wen-Juan; Pannecouque, Christophe; De Clercq, Erik; Corona, Angela; Maloccu, Stefania; Tramontano, Enzo; Wang, Shuai; Chen, Fen-Er
err分享
err收藏

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