未登录.png)
分享.png)
收藏分享 收藏 分享 收藏 CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells
Khamidullina, Alvina I.; Yastrebova, Margarita A.; Bruter, Alexandra V.; Nuzhina, Julia V.; Vorobyeva, Nadezhda E.; Khrustaleva, Anastasia M.; Varlamova, Ekaterina A.; Tyakht, Alexander V.; Abramenko, Iaroslav E.; Ivanova, Ekaterina S.; Zamkova, Maria A.; Li, Jing; Lim, Chang-Uk; Chen, Mengqian; Broude, Eugenia V.; Roninson, Igor B.; Shtil, Alexander A.; Tatarskiy, Victor V. 分享 收藏 分享 收藏 Mediator kinase inhibitors suppress triple- negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors介质激酶抑制剂通过mTOR和AKT抑制剂抑制三阴性乳腺癌的生长并延长肿瘤抑制Ding, Xiaokai; Liang, Jiaxin; Sharko, Amanda C.; Hilimire, Thomas A.; Li, Jing; Loskutov, Jurgen; Mack, Zachary T.; Ji, Hao; Schools, Gary P.; Cai, Chao; Pugacheva, Elena N.; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia V. 分享 收藏 Mediator kinase inhibition reverses castration resistance of advanced cancerLi, Jing; Hilimire, Thomas A.; Liu, Yueying; Wang, Lili; Liang, Jiaxin; Gyorffy, Balazs; Sikirzhytski, Vitali; Ji, Hao; Zhang, Li; Cheng, Chen; Ding, Xiaokai; Kerr, Kendall R.; Dowling, Charles E.; Chumanevich, Alexander A.; Mack, Zachary T.; Schools, Gary P.; Lim, Chang-uk; Ellis, Leigh; Zi, Xiaolin; Porter, Donald C.; Broude, Eugenia V.; McInnes, Campbell; Wilding, George; Lilly, Michael B.; Roninson, Igor B.; Chen, Mengqian 分享 收藏 CDK8/19-regulated transcriptional reprogramming: a druggable driver of castration-resistant prostate cancerLi, Jing; Hilimire, Thomas; Liu, Yueying; Wang, Lili; Liang, Jiaxin; Gyorffy, Balazs; Sikitzhytski, Vitali; Ji, Hao; Zhang, Li; Cheng, Chen; Ding, Xiaokai; Kerr, Kendall; Dowling, Charles; Schools, Gary; Lim, Chang-Uk; Braude, Eugenia; Wilding, George; Lilly, Michael; Roninson, Igor; Chen, Mengqian 分享 收藏 Loss of RACK1 promotes glutamine addiction via activating AKT/mTOR/ASCT2 axis to facilitate tumor growth in gastric cancerChen, Mengqian; Wang, Gaojia; Xu, Zhijian; Sun, Jie; Liu, Bo; Chang, Lei; Gu, Jianxin; Ruan, Yuanyuan; Gao, Xiaodong; Song, Shushu 分享 收藏 CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteinsChen, Mengqian; Li, Jing; Zhang, Li; Wang, Lili; Cheng, Chen; Ji, Hao; Altilia, Serena; Ding, Xiaokai; Cai, Guoshuai; Altomare, Diego; Shtutman, Michael; Byrum, Stephanie D.; Mackintosh, Samuel G.; Feoktistov, Alexey; Soshnikova, Nataliya; Mogila, Vladislav A.; Tatarskiy, Victor; Erokhin, Maksim; Chetverina, Darya; Prawira, Angga; Ni, Yi; Urban, Stephan; McInnes, Campbell; Broude, Eugenia, V; Roninson, Igor B. 分享 收藏 分享 收藏 分享 收藏 Dual therapeutic targeting of CDK8/19 and mTOR in triple negative breast cancerDing, Xiaokai; Ji, Hao; Sharko, Amanda C.; Loskutov, Juergen; Mack, Zachary; Myers, Jadyn; Chen, Mengqian; Pugacheva, Elena; Roninson, Igor; Broude, Eugenia 分享 收藏 分享 收藏 分享 收藏 Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivoDing, Xiaokai; Sharko, Amanda C.; McDermott, Martina S. J.; Schools, Gary P.; Chumanevich, Alexander; Ji, Hao; Li, Jing; Zhang, Li; Mack, Zachary T.; Sikirzhytski, Vitali; Shtutman, Michael; Ivers, Laura; O'Donovan, Norma; Crown, John; Gyorffy, Balazs; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia, V 分享 收藏 A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched PharmacokineticsZhang, Li; Cheng, Chen; Li, Jing; Wang, Lili; Chumanevich, Alexander A.; Porter, Donald C.; Mindich, Aleksei; Gorbunova, Svetlana; Roninson, Igor B.; Chen, Mengqian; McInnes, Campbell 分享 收藏 pVHL promotes lysosomal degradation of YAP in lung adenocarcinomaHu, Lan; Wu, Hao; Jiang, Tian; Kuang, Mengzhen; Liu, Bo; Guo, Xinying; He, Daochuan; Chen, Mengqian; Gu, Jie; Gu, Jianxin; Chang, Lei; Feng, Mingxiang; Ruan, Yuanyuan 分享 收藏 分享 收藏 分享 收藏 
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
