未登录 Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance Zatreanu, Diana A.; Robinson, Helen M. R.; Alkhatib, Omar; Boursier, Marie; Finch, Harry; Geo, Lerin; Grande, Diego; Grinkevich, Vera; Heald, Robert; Langdon, Sophie; Majithiya, Jayesh; McWhirter, Claire; Martin, Niall M. B.; Moore, Shaun; Neves, Joana; Rajendra, Eeson; Ranzani, Marco; Schaedler, Theresia; Stockley, Martin; Wiggins, Kimberley; Brough, Rachel; Sridhar, Sandhya; Gulati, Aditi; Shao, Nan; Badder, Luned M.; Novo, Daniela; Knight, Eleanor G.; Marlow, Rebecca; Haider, Syed; Callen, Elsa; Hewitt, Graeme; Schimmel, Joost; Prevo, Remko; Alli, Christina; Ferdinand, Amanda; Bell, Cameron; Blencowe, Peter; Calder, Mathew; Charles, Mark; Curry, Jayne; Ekwuru, Tennyson; Ewings, Katherine; Nussenzweig, Andre; Tijsterman, Marcel; Tutt, Andrew; Boulton, Simon J.; Higgins, Geoff S.; Pettitt, Steve; Smith, Graeme C. M.; Lord, Christopher J. 分享 收藏
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance Pol θ 抑制剂引起BRCA基因合成致死率和靶向PARP抑制剂抗性 Zatreanu, Diana; Robinson, Helen M. R.; Alkhatib, Omar; Boursier, Marie; Finch, Harry; Geo, Lerin; Grande, Diego; Grinkevich, Vera; Heald, Robert A.; Langdon, Sophie; Majithiya, Jayesh; McWhirter, Claire; Martin, Niall M. B.; Moore, Shaun; Neves, Joana; Rajendra, Eeson; Ranzani, Marco; Schaedler, Theresia; Stockley, Martin; Wiggins, Kimberley; Brough, Rachel; Sridhar, Sandhya; Gulati, Aditi; Shao, Nan; Badder, Luned M.; Novo, Daniela; Knight, Eleanor G.; Marlow, Rebecca; Haider, Syed; Callen, Elsa; Hewitt, Graeme; Schimmel, Joost; Prevo, Remko; Alli, Christina; Ferdinand, Amanda; Bell, Cameron; Blencowe, Peter; Bot, Chris; Calder, Mathew; Charles, Mark; Curry, Jayne; Ekwuru, Tennyson; Ewings, Katherine; Krajewski, Wojciech; MacDonald, Ellen; McCarron, Hollie; Pang, Leon; Pedder, Chris; Rigoreau, Laurent; Swarbrick, Martin; Wheatley, Ed; Willis, Simon; Wong, Ai Ching; Nussenzweig, Andre; Tijsterman, Marcel; Tutt, Andrew; Boulton, Simon J.; Higgins, Geoff S.; Pettitt, Stephen J.; Smith, Graeme C. M.; Lord, Christopher J. 分享 收藏
Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors Murray, Christopher W.; Berdini, Valerio; Buck, Ildiko M.; Carr, Maria E.; Cleasby, Anne; Coyle, Joseph E.; Curry, Jayne E.; Day, James E. H.; Day, Phillip J.; Hearn, Keisha; Iqbal, Aman; Lee, Lydia Y. W.; Martins, Vanessa; Mortenson, Paul N.; Munck, Joanne M.; Page, Lee W.; Patel, Sahil; Roomans, Susan; Smith, Kirsten; Tamanini, Emiliano; Saxty, Gordon 分享 收藏
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A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation Chan, King Chi; Ting, Choi Man; Chan, Pui Shan; Lo, Ming Chu; Lo, Kwok Wai; Curry, Jayne E.; Smyth, Tomoko; Lee, Anne Wing Mui; Ng, Wai Tong; Tsao, George Sai Wah; Wong, Ricky Ngok Shun; Lung, Maria Li; Mak, Nai Ki 分享 收藏
The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models Smyth, Tomoko; Van Looy, Thomas; Curry, Jayne E.; Rodriguez-Lopez, Ana M.; Wozniak, Agnieszka; Zhu, Meijun; Donsky, Rachel; Morgan, Jennifer G.; Mayeda, Mark; Fletcher, Jonathan A.; Schoffski, Patrick; Lyons, John; Thompson, Neil T.; Wallis, Nicola G. 分享 收藏
AT13387, an HSP90 inhibitor, is effective in both vemurafenib-sensitive and -resistant melanoma models Rodriguez-Lopez, Ana M.; Smyth, Tomoko; Curry, Jayne; Graham, Brent; McMenamin, Rachel; Lyons, John; Thompson, Neil; Wallis, Nicola 分享 收藏
Pharmacodynamic and antitumor activity of fragment-derived inhibitors of MetAP2 in tumor xenografts Smyth, Tomoko; Curry, Jayne; Wilsher, Nicola; Johnson, Chris; Berdini, Valerio; Richardson, Caroline; Massey, Frances; McMenamin, Rachel; Griffiths-Jones, Charlotte; Thompson, Neil; Wallis, Nicola G. 分享 收藏
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Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity Howard, Steven; Berdini, Valerio; Boulstridge, John A.; Carr, Maria G.; Cross, David M.; Curry, Jayne; Devine, Lindsay A.; Early, Theresa R.; Fazal, Lynsey; Gill, Adrian L.; Heathcote, Michelle; Maman, Sarita; Matthews, Julia E.; McMenamin, Rachel L.; Navarro, Eva F.; O'Brien, Michael A.; O'Reilly, Marc; Rees, David C.; Reule, Matthias; Tisi, Dominic; Williams, Glyn; Vinkovic, Mladen; Wyatt, Paul G. 分享 收藏
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Identification of novel p38α MAP kinase inhibitors using fragment-based lead generation Gill, AL; Frederickson, M; Cleasby, A; Woodhead, SJ; Carr, MG; Woodhead, AJ; Walker, MT; Congreve, MS; Devine, LA; Tisi, D; O'Reilly, M; Seavers, LCA; Davis, DJ; Curry, J; Anthony, R; Padova, A; Murray, CW; Carr, RAE; Jhoti, H 分享 收藏
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