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C

Christopher J. Lord

Institute of Cancer Research
H指数:98
被引数:4.5万

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PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer

PUM3是同源重组缺陷型乳腺癌中复制应激所必需的抑制因子

Nature Communications
IF15.7
2026-09-210
OAAI
Valeria Amodeo; Daniel Weekes; Nicolae Balan; Rebeca Uceda Castro; Nadja D’Uonno; Asha Konde; Elodie Noel; Luisa Robbez-Masson; Jennifer Trendell; Maya Shlomi; Callum Walker; Anjan Venkatesh; Colm J. Ryan; Sarah C. Moser; Jos Jonkers; Laurence H. Pearl; Antony W. Oliver; Dragomir B. Krastev; Syed Haider; Anita Grigoriadis; Stephen J. Pettitt; Christopher J. Lord; Andrew N. J. Tutt
The anion channel GPR89 is a tumor-specific dependency in breast cancer

GPR89阴离子通道是乳腺癌的肿瘤特异性依赖

Nature Communications
IF15.7
2026-08-240
OA
Riccardo Ferro; Alexandra Carroll; Ana M. Mendes-Pereira; Virinder Reen; George Vlachogiannis; Rebeca Uceda-Castro; Dragomir Krastev; Valeria Amodeo; Stephen Pettitt; Nadja D’Uonno; Ioanna Mavrommati; Blanca Navarro; Luke Hitchen; Jennifer Trendell; Ana Stojiljkovic; Cynthia Prince; Narinder Janghra; Ioannis Roxanis; Patrycja Gazinska; Daniel Larcombe-Young; Rebecca Marlow; Stefano Annunziato; Jos Jonkers; Tejashree Rajaram Kanitkar; Amadeus Xu; Nirmesh Patel; Nalan Liv; John Alexander; Jelmar Quist; Mercedes Pardo; Theodoros I. Roumeliotis; Jyoti S. Choudhary; Daniel Weekes; Pierfrancesco Marra; Joanna I. Loizou; Rachael Natrajan; Anita Grigoriadis; Mallur Srivatsan Madhusudhan; Syed Haider; Christopher J. Lord; Andrew Tutt
Nucleophagy removes cytotoxic trapped PARP1

核质吞噬清除细胞毒性被困的PARP1

Nature Cell Biology
IF19.1
2026-06-020
OAAI
Gwendoline Hoslett; Sara Tribble; Pauline Lascaux; Stelios Koukouravas; Ignacio Torrecilla; Wei Song; Cynthia X. Hou; Junyi Li; Martín González-Fernández; Giuliana De Gregoriis; Rebecca A. Dagg; Darragh O’Brien; Andrea Pierangelini; Thibaud Martial; Alvin Wei Tian Ng; Nuno Raimundo; Ira Milosevic; Raimundo Freire; Yuliang Li; Sven Rottenberg; Dragomir B. Krastev; Christopher J. Lord; Madalena Tarsounas; Kristijan Ramadan
Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha

通过选择性抑制IκB激酶α靶向CYLD皮肤综合征中的非经典NF-κB信号通路

British Journal of Dermatology
IF9.6
2026-03-040
OA
Kirsty Hodgson; Joseph Inns; Gary Reynolds; Emily Stephenson; Andrew Paul; Naomi Sinclair; Giacomo Berretta; Christopher Lawson; Andrew Michael Frey; Iglika Ivanova; Eva Adam; Christopher J Lord; Simon Cockell; Jonathan Coxhead; Nikoletta Nagy; David Adams; Marta Szell; Matthias Trost; Muzlifah Haniffa; Simon P Mackay; Neil Perkins; Neil Rajan; null
NASP modulates histone turnover to drive PARP inhibitor resistance

NASP通过调节组蛋白周转来驱动PARP抑制剂耐药性。

Nature
IF48.5
2025-08-130
PRE
Sarah C. Moser; Anna Khalizieva; Josef Roehsner; Elisabeth Pottendorfer; Milo L. Kaptein; Giulia Ricci; Vivek Bhardwaj; Onno B. Bleijerveld; Liesbeth Hoekman; Ingrid van der Heijden; Simone di Sanzo; Alexander Fish; Aleksandra Chikunova; Judith H. I. Haarhuis; Roel Oldenkamp; Luisa Robbez-Masson; Justin Sprengers; Daniel J. Vis; Lodewyk F. A. Wessels; Marieke van de Ven; Stephen J. Pettitt; Andrew N. J. Tutt; Christopher J. Lord; Benjamin D. Rowland; Moritz Völker-Albert; Francesca Mattiroli; Thijn R. Brummelkamp; Abdelghani Mazouzi; Jos Jonkers
Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial

通过姑息性放疗和ATR抑制实现肿瘤控制和免疫激活，PATRIOT Part C：一项 Ib 期临床试验

Nature Communications
IF15.7
2025-08-010
OAAI
Magnus T. Dillon; Emmanuel C. Patin; Kabir Mohammed; Jeane Guevara; Simon A. Smith; Emma Dean; Heba Soliman; Pablo Nenclares; Motoko Ryugenji; Davina Northcote; Neel Shah; Lorna Grove; Christopher J. Lord; Stephen Pettit; Matt Tall; Karen E. Swales; Udai Banerji; Alan A. Melcher; Mark Saunders; Martin D. Forster; Kevin J. Harrington
Clinical challenges and proposed solutions for patients with invasive lobular breast cancer

浸润性小叶乳腺癌患者的临床挑战和建议的解决方案

Annals of Oncology
IF65.4
2025-07-210
OAAI
K. Van Baelen; E. Sawyer; J. Van Cauwenberge; P. Aftimos; M.F. Covington; M. Maetens; G. Zels; C. Brisken; L. Djerroudi; R. Dresen; A. Fitzpatrick; R.L. Flaherty; G. Floris; S. Freeney; A.B. Hanker; D. Honey; C.M. Isacke; R.C. Jankowitz; R. Jeselsohn; T. Koorman; C. Kuhl; S. Linn; C.J. Lord; C. Malhaire; J. Mouabbi; R. Mukhtar; G. Nader-Marta; R. Natrajan; P. Neven; S. Oesterreich; J.L. Sandoval; S.J. Schnitt; E. Senkus; C. Turner; V. Vandecaveye; H. Wildiers; A. Vincent-Salomon; P.W.B. Derksen; C. Desmedt
Author Correction: Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

作者更正: Palbociclib和dsRNA传感器合作通过ER应激和调节免疫逃避来增强抗癌作用

Nature Communications
IF15.7
2025-07-150
OAAI
Victoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington
The PARP inhibitor talazoparib synergizes with reovirus to induce cancer killing and tumour control in vivo in mouse models

PARP抑制剂talazoparib与呼肠孤病毒协同作用，在小鼠模型中体内诱导癌症杀伤和肿瘤控制

Nature Communications
IF15.7
2025-07-080
OAAI
Joan Kyula-Currie; Victoria Roulstone; James Wright; Francesca Butera; Arnaud Legrand; Richard Elliott; Martin McLaughlin; Galabina Bozhanova; Dragomir Krastev; Stephen Pettitt; Tencho Tenev; Magnus Dillon; Shane Foo; Emmanuel C. Patin; Victoria Jennings; Charleen Chan Wah Hak; Elizabeth Appleton; Amarin Wongariyapak; Malin Pedersen; Antonio Rullan; Jyoti Choudhary; Chris Bakal; Pascal Meier; Christopher J. Lord; Alan Melcher; Kevin J. Harrington
Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion
Nature Communications
IF15.7
2025-05-250
OAAI
Victoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington
Unraveling complexity and leveraging opportunities in uncommon breast cancer subtypes
NPJ BREAST CANCER
IF7.6
2025-01-240
OAAI
Pareja, Fresia; Bhargava, Rohit; Borges, Virginia F.; Brogi, Edi; Canas Marques, Rita; Cardoso, Fatima; Desmedt, Christine; Harigopal, Malini; Lakhani, Sunil R.; Lee, Adrian; Leone, Jose Pablo; Linden, Hannah; Lord, Christopher J.; Marchio, Caterina; Merajver, Sofia D.; Rakha, Emad; Reis-Filho, Jorge S.; Richardson, Andrea; Sawyer, Elinor; Schedin, Pepper; Schwartz, Christopher J.; Tutt, Andrew; Ueno, Naoto T.; Vincent-Salomon, Anne; Weigelt, Britta; Wen, Y. Hannah; Schnitt, Stuart J.; Oesterreich, Steffi
CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13
CELL REPORTS MEDICINE
IF10.6
2024-10-010
OAAI
Tien, Jean Ching-Yi; Luo, Jie; Chang, Yu; Zhang, Yuping; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Mahapatra, Somnath; Shah, Palak; Wang, Xiao-Ming; Todd, Abigail J.; Eyunni, Sanjana; Cheng, Caleb; Rebernick, Ryan J.; Xiao, Lanbo; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen J.; Cao, Xuhong; Miner, Stephanie J.; Zhou, Licheng; Wu, Yi-Mi; Labanca, Estefania; Wang, Yuzhuo; Parolia, Abhijit; Cieslik, Marcin; Robinson, Dan R.; Wang, Zhen; Feng, Felix Y.; Chou, Jonathan; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
CDK12 loss promotes prostate cancer development while exposing vulnerabilities to paralog-based synthetic lethality
MOLECULAR CANCER THERAPEUTICS
IF5.5
2024-06-100
PRE
Tien, Jean C.; Chang, Yu; Zhang, Yuping; Chou, Jonathan; Cheng, Yunhui; Wang, Xiaoju; Yang, Jianzhang; Mannan, Rahul; Shah, Palak; Wang, Xiao-Ming; Todd, Abbey; Eyunni, Sanjana; Cheng, Caleb; Cao, Xuhong; Bao, Yi; Neiswender, James; Brough, Rachel; Pettitt, Stephen; Labanca, Estefania; Wang, Yuzhuo; Cieslik, Marcin; Lord, Christopher J.; Ding, Ke; Chinnaiyan, Arul M.
RNASEH2B loss and PARP inhibition in advanced prostate cancer
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2024-06-040
OAAI
Carmichael, Juliet; Figueiredo, Ines; Gurel, Bora; Beije, Nick; Yuan, Wei; Rekowski, Jan; Seed, George; Carreira, Suzanne; Bertan, Claudia; de La Maza, Maria de Los Dolores Fenor; Chandran, Khobe; Neeb, Antje; Welti, Jon; Gallagher, Lewis; Bogdan, Denisa; Crespo, Mateus; Riisnaes, Ruth; Ferreira, Ana; Miranda, Susana; Lu, Jinqiu; Shen, Michael M.; Hall, Emma; Porta, Nuria; Westaby, Daniel; Guo, Christina; Grochot, Rafael; Lord, Christopher J.; Mateo, Joaquin; Sharp, Adam; de Bono, Johann
Functional assessment of RAD51 foci and replication fork dynamics in PARPi resistant BRCA1/2 mutated breast cancer
CANCER RESEARCH
IF16.6
2024-05-020
PRE
Harvey-Jones, Elizabeth; Raghunandan, Maya; Robbez-Masson, Luisa; Alaguthurai, Thanussuyah; Llop-Guevara, Alba; Trendell, Jennifer; Rodriguez, Olga; Guzman, Marta; Weekes, Daniel; deRenty, Christelle; Knight, Eleanor; Marlow, Rebecca; Starling, Christopher; Liu, Ruifang; Ravindran, Nivedita; Roxanis, Ioannis; Lukashchuk, Natalia; Serra, Violeta; Pettitt, Stephen; Lord, Christopher; Tutt, Andrew N. J.
Longitudinal pro fi ling identi fi es co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer
ANNALS OF ONCOLOGY
IF65.4
2024-04-0113
OA
Harvey-Jones, E.; Raghunandan, M.; Robbez-Masson, L.; Magraner-Pardo, L.; Alaguthurai, T.; Yablonovitch, A.; Yen, J.; Xiao, H.; Brough, R.; Frankum, J.; Song, F.; Yeung, J.; Savy, T.; Gulati, A.; Alexander, J.; Kemp, H.; Starling, C.; Konde, A.; Marlow, R.; Cheang, M.; Proszek, P.; Hubank, M.; Cai, M.; Trendell, J.; Lu, R.; Liccardo, R.; Ravindran, N.; Llop-Guevara, A.; Rodriguez, O.; Balmana, J.; Lukashchuk, N.; Dorschner, M.; Drusbosky, L.; Roxanis, I.; Serra, V.; Haider, S.; Pettitt, S. J.; Lord, C. J.; Tutt, A. N. J.

研究方向

暂未获取到该数据
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Alan Ashworth
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S
Stephen J. Pettitt
H 指数:31论文数:214被引数:5,627
R
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H 指数:35论文数:264被引数:9,557
R
Rachael Natrajan
H 指数:66论文数:389被引数:1.5万
J
Jessica Frankum
H 指数:24论文数:198被引数:4,031
A
Andrew Tutt
H 指数:103论文数:781被引数:8.7万
I
Ilirjana Bajrami
H 指数:24论文数:183被引数:3,786
J
James Campbell
H 指数:39论文数:104被引数:6,372
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H 指数:50论文数:242被引数:8,909
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Jorge S. Reis‐Filho
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