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Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo 查加斯病的药物再利用: 氯喹在体外和体内增强了对克氏锥虫的苯并硝唑活性 Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, Caio Haddad; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; Barrios, Leda Castano; Lannes-Vieira, Joseli; Cariste, Leonardo Moro; Vasconcelos, Jose Ronnie; Moraes, Carolina Borsoi; Freitas-Junior, Lucio H.; Kalil, Jorge; Alcantara, Laura; Cunha-Neto, Edecio 分享 收藏
In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.) Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphael; Barbosa, Euzebio Guimaraes; Panciera, Michele; Correia, Carlos Roque D.; Rodrigues, Maria Joao; Custodio, Luisa 分享 收藏
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y. A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; Torrecilhas, Ana Claudia; Romera, Lavinia M. D.; Madeira, Rafael Pedro; Schenkman, Sergio; Freitas-Junior, Lucio H.; Chatelain, Eric; Miles, Michael A.; Moraes, Carolina B. 分享 收藏
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors Bonatto, Vinicius; Jatai Batista, Pedro Henrique; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; de Albuquerque, Sergio; Moraes, Carolina Borsoi; Franco, Caio Haddad; Lameira, Jeronimo; Leitao, Andrei; Montanari, Carlos A. 分享 收藏
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics 通过药物化学，筛选和基因组学的应用，在利什曼原虫中发现苯并噻吩-黄酮醇可阻止米替福新和锑耐药性 Borsari, Chiara; Dolores Jimenez-Anton, Maria; Eick, Julia; Bifeld, Eugenia; Jose Torrado, Juan; Isabel Olias-Molero, Ana; Jesus Corral, Maria; Santarem, Nuno; Baptista, Catarina; Severi, Leda; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Luciani, Rosaria; Nevado, Paloma Tejera; Zander-Dinse, Dorothea; Franco, Caio H.; Ferrari, Stefania; Moraes, Carolina B.; Cordeiro-da-Silva, Anabela; Ponterini, Glauco; Clos, Joachim; Maria Alunda, Jose; Paola Costi, Maria 分享 收藏
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; Rocho, Fernanda dos Reis; Martins Silva, Samelyn da Costa; Jatai Batista, Pedro Henrique; Moraes, Carolina Borsoi; Franco, Caio Haddad; Freitas-Junior, Lucio H. G.; Kenny, Peter W.; Leitao, Andrei; Burtoloso, Antonio C. B.; de Vita, Daniela; Montanari, Carlos A. 分享 收藏
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections 增强苯并噻唑作为蝶啶还原酶-1抑制剂治疗锥虫感染 Linciano, Pasquale; Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B.; Mueller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pohner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola 分享 收藏
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Aryl thiosemicarbazones for the treatment of trypanosomatidic infections 用于治疗锥虫感染的芳基硫代氨基脲 Linciano, Pasquale; Moraes, Carolina B.; Alcantara, Laura M.; Franco, Caio H.; Pascoalino, Bruno; Freitas-Junior, Lucio H.; Macedo, Sara; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Ferrari, Stefania; Luciani, Rosaria; Quotadamo, Antonio; Costantino, Luca; Costi, Maria Paola 分享 收藏
Investigating the structure-activity relationships of N′-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds Palace-Berl, Fanny; Mesquita Pasqualoto, Kerly Fernanda; Zingales, Bianca; Moraes, Carolina Borsoi; Bury, Mariana; Franco, Caio Haddad; da Silva Neto, Adelson Lopes; Murayama, Joao Sussumu; Nunes, Solange Lessa; Silva, Marcelo Nunes; Tavares, Leoberto Costa 分享 收藏
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Methoxylated 2′-hydroxychalcones as antiparasitic hit compounds 甲氧基化2 ′-羟基查耳酮作为抗寄生虫化合物 Borsari, Chiara; Santarem, Nuno; Torrado, Juan; Olias, Ana Isabel; Corral, Maria Jesus; Baptista, Catarina; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Gribbon, Philip; Reinshagen, Jeanette; Linciano, Pasquale; Tait, Annalisa; Costantino, Luca; Freitas-Junior, Lucio H.; Moraes, Carolina B.; dos Santos, Pascoalino Bruno; Alcantara, Laura Maria; Franco, Caio Haddad; Bertolacini, Claudia Danielli; Fontana, Vanessa; Nevado, Paloma Tejera; Clos, Joachim; Alunda, Jose Maria; Cordeiro-da-Silva, Anabela; Ferrari, Stefania; Costi, Maria Paola 分享 收藏
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