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D

Daniel O'Neill

biopharmaceutical r&d
H指数:15
被引数:883

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AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions

AZ14289671 是一种高选择性的血脑屏障穿透性不可逆TKI，可靶向EGFRExon20插入突变。

Cell Reports Medicine
IF10.6
2025-08-250
OAAI
Aisha M. Swaih; Sara Talbot; Adriana Savoca; Hannah Thorpe; Vikki Flemington; Benjamin Phillips; Nicola Colclough; William McCoull; Veronika Radeva; David Hargreaves; Martin J. Packer; Catarina Felisberto-Rodrigues; Clare Thomson; Jonathan P. Orme; Carly Deane; Aaron Smith; Peter Johnström; Magnus Schou; Lisa McWilliams; Paul Davey; Marianne Enget; Daniel O'Neill; Sabina Cosulich; Nicolas Floc’h
Genome-wide CRISPR screens identify the YAP/TEAD axis as a driver of persister cells in EGFR mutant lung cancer
COMMUNICATIONS BIOLOGY
IF5.1
2024-04-249
OAAI
Pfeifer, Matthias; Brammeld, Jonathan S.; Price, Stacey; Pilling, James; Bhavsar, Deepa; Farcas, Anca; Bateson, Jessica; Sundarrajan, Anjana; Miragaia, Ricardo J.; Guan, Nin; Arnold, Stephanie; Tariq, Laiba; Grondine, Michael; Talbot, Sarah; Guerriero, Maria Lisa; O'Neill, Daniel J.; Young, Jamie; Company, Carlos; Dunn, Shanade; Thorpe, Hannah; Martin, Matthew J.; Maratea, Kimberly; Barrell, Daniel; Ahdesmaki, Miika; Mettetal, Jerome T.; Brownell, James; Mcdermott, Ultan
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-06-218
OAAI
Michaelides, Iacovos N.; Collie, Gavin W.; Borjesson, Ulf; Vasalou, Christina; Alkhatib, Omar; Barlind, Louise; Cheung, Tony; Dale, Ian L.; Embrey, Kevin J.; Hennessy, Edward J.; Khurana, Puneet; Koh, Cheryl M.; Lamb, Michelle L.; Liu, Jianming; Moss, Thomas A.; O'Neill, Daniel J.; Phillips, Christopher; Shaw, Joseph; Snijder, Arjan; Storer, R. Ian; Stubbs, Christopher J.; Han, Fujin; Li, Chengzhi; Qiao, Jingchuan; Sun, Dong-Qing; Wang, Jingwen; Wang, Peng; Yang, Wenzhen
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-0721
PRE
Finlay, M. Raymond, V; Barton, Peter; Bickerton, Sue; Bista, Michal; Colclough, Nicola; Cross, Darren A. E.; Evans, Laura; Floc'h, Nicolas; Gregson, Clare; Guerot, Carine M.; Hargreaves, David; Kang, Xiaoming; Lenz, Eva M.; Li, Xu; Liu, Yi; Lorthioir, Olivier; Martin, Matthew J.; McKerrecher, Darren; McWhirter, Claire; O'Neill, Daniel; Orme, Jonathan P.; Mosallanejad, Arash; Rahi, Amar; Smith, Paul D.; Talbot, Verity; Ward, Richard A.; Wrigley, Gail; Wylot, Marta; Xue, Lin; Yao, Tieguang; Ye, Yang; Zhao, Xiliang
Comparative activity profiling of tyrosine kinase inhibitors (TKIs) against exon 20 insertions and the wild-type form of epidermal growth factor receptor (EGFR)
CANCER RESEARCH
IF16.6
2019-07-011
PRE
Ward, Richard A.; Bianco, Ambra; Colclough, Nicola; Cross, Darren; Cuomo, Emanuela M.; Finlay, M. Raymond V.; Fitzek, Martina; Floc'h, Nicolas; Gagrica, Sladjana; Hammond, Beverley; Martin, Matthew J.; McKerrecher, Darren; O'Neill, Daniel J.; Orme, Jonathan P.; Smith, Paul D.; Staniszewska, Anna D.; Urosevic, Jelena; Whalley, Nicky; Yates, James W.
Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-04-3084
OAAI
Floc'h, Nicolas; Martin, Matthew J.; Riess, Jonathan W.; Orme, Jonathan P.; Staniszewska, Anna D.; Menard, Ludovic; Cuomo, Maria Emanuela; O'Neill, Daniel J.; Ward, Richard A.; Finlay, M. Raymond V.; McKerrecher, Darren; Cheng, Mingshan; Vang, Daniel P.; Burich, Rebekah A.; Keck, James G.; Gandara, David R.; Mack, Philip C.; Cross, Darren A. E.
Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
CANCER RESEARCH
IF16.6
2012-04-013
PRE
Loddick, Sarah A.; Bradbury, Rob; Broadbent, Nicola; Campbell, Hayley; Gaughan, Luke; Growcott, Jim; Stratton, Natalie; Mouchet, Elizabeth; O'Neill, Daniel; Rabow, Al; Robinson, David; Robson, Craig N.; Ross, Sarah J.; Shaheen, Fadhel; Trueman, Dawn; Walker, Graeme; Wedge, Stephen R.; Brooks, Nigel A. N.

研究方向

暂未获取到该数据
N
Nicolas Floc’h
H 指数:17论文数:166被引数:1,737
J
Jonathan P. Orme
H 指数:10论文数:59被引数:785
D
Darren A.E. Cross
H 指数:38论文数:217被引数:1.5万
M
M. Raymond V. Finlay
H 指数:25论文数:133被引数:5,709
R
Richard A. Ward
H 指数:51论文数:308被引数:1.0万
M
Matthew J. Martin
H 指数:24论文数:129被引数:2,738
N
Nicola Colclough
H 指数:24论文数:123被引数:3,013
D
Darren McKerrecher
H 指数:18论文数:56被引数:1,579
C
Craig Robson
H 指数:65论文数:483被引数:1.2万
A
Anna D. Staniszewska
H 指数:20论文数:147被引数:1,823