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N

Nicola Colclough

dmpk
H指数:24
被引数:3,013

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AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions

AZ14289671 是一种高选择性的血脑屏障穿透性不可逆TKI，可靶向EGFRExon20插入突变。

Cell Reports Medicine
IF10.6
2025-08-250
OAAI
Aisha M. Swaih; Sara Talbot; Adriana Savoca; Hannah Thorpe; Vikki Flemington; Benjamin Phillips; Nicola Colclough; William McCoull; Veronika Radeva; David Hargreaves; Martin J. Packer; Catarina Felisberto-Rodrigues; Clare Thomson; Jonathan P. Orme; Carly Deane; Aaron Smith; Peter Johnström; Magnus Schou; Lisa McWilliams; Paul Davey; Marianne Enget; Daniel O'Neill; Sabina Cosulich; Nicolas Floc’h
Achieving human brain exposure with the oral ataxia-telangiectasia mutated kinase inhibitor AZD1390, a substrate of aldehyde oxidase

通过口服A-T突变酶抑制剂AZD1390（醛氧化酶底物）实现人脑暴露。

Drug Metabolism and Disposition
IF4
2025-06-030
PRE
Nicola Colclough; Alexandra L. Orton; Scott Martin; Martin Wild; Venkatesh Pilla Reddy; Eva Lenz; Roshini Markandu; Joanne Wilson; Chunling Fan; Julian Potter; David Dai; Christina Chan; Jennie Roberts; Aixiang Xue; Petar Pop-Damkov; Andy Sykes; Barry Jones; Thomas A. Hunt; Kurt G. Pike; Dermot F. McGinnity
Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-280
PRE
Thomson, Clare; Braybrooke, Erin; Colclough, Nicola; Davies, Nichola L.; Floc'h, Nicolas; Greenwood, Ryan; Guerot, Carine; Hargreaves, David; Johnstrom, Peter; Khurana, Puneet; Kostomiris, Demetrios H.; Li, Songlei; Lister, Andrew; Lorthioir, Olivier; Martin, Scott; Mccoull, William; Mclean, Neville J.; Mcwilliams, Lisa; Orme, Jonathan P.; Packer, Martin J.; Pearson, Stuart; Swaih, Aisha M.; Tentarelli, Sharon; Tucker, Michael J.; Ward, Richard A.; Wilkinson, Stephen; Winlow, Poppy; Wood, Isabel L.
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-05-212
PRE
Thomson, Clare; Barton, Peter; Braybrooke, Erin; Colclough, Nicola; Dong, Zhiqiang; Evans, Laura; Floc'h, Nicolas; Guerot, Carine; Hargreaves, David; Khurana, Puneet; Li, Songlei; Li, Xiuwei; Lister, Andrew; McCoull, William; McWilliams, Lisa; Orme, Jonathan P.; Packer, Martin J.; Swaih, Aisha M.; Ward, Richard A.; Winlow, Poppy; Ye, Yang
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-02-024
PRE
Pike, Kurt G.; Hunt, Thomas A.; Barlaam, Bernard; Benstead, David; Cadogan, Elaine; Chen, Kan; Cook, Calum R.; Colclough, Nicola; Deng, Chao; Durant, Stephen T.; Eatherton, Andrew; Goldberg, Kristin; Johnstro''m, Peter; Liu, Libin; Liu, Zhaoqun; Nissink, J. Willem M.; Pang, Chengling; Pass, Martin; Robb, Graeme R.; Roberts, Caroline; Schou, Magnus; Steward, Oliver; Sykes, Andy; Yan, Yumei; Zhai, Baochang; Zheng, Li
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer
NATURE COMMUNICATIONS
IF15.7
2022-12-1216
OAAI
Adua, Sally J.; Arnal-Estape, Anna; Zhao, Minghui; Qi, Bowen; Liu, Zongzhi Z.; Kravitz, Carolyn; Hulme, Heather; Strittmatter, Nicole; Lopez-Giraldez, Francesc; Chande, Sampada; Albert, Alexandra E.; Melnick, Mary-Ann; Hu, Bomiao; Politi, Katerina; Chiang, Veronica; Colclough, Nicola; Goodwin, Richard J. A.; Cross, Darren; Smith, Paul; Nguyen, Don X.
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain-a Game Changing Parameter for CNS Drug Discovery and Development

未结合的脑-血浆分配系数，Kp，uu，脑-CNS药物发现和开发的游戏改变参数

PHARMACEUTICAL RESEARCH
IF4.3
2022-04-1162
OAAI
Loryan, Irena; Reichel, Andreas; Feng, Bo; Bundgaard, Christoffer; Shaffer, Christopher; Kalvass, Cory; Bednarczyk, Dallas; Morrison, Denise; Lesuisse, Dominique; Hoppe, Edmund; Terstappen, Georg C.; Fischer, Holger; Di, Li; Colclough, Nicola; Summerfield, Scott; Buckley, Stephen T.; Maurer, Tristan S.; Friden, Markus
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-09-0721
PRE
Finlay, M. Raymond, V; Barton, Peter; Bickerton, Sue; Bista, Michal; Colclough, Nicola; Cross, Darren A. E.; Evans, Laura; Floc'h, Nicolas; Gregson, Clare; Guerot, Carine M.; Hargreaves, David; Kang, Xiaoming; Lenz, Eva M.; Li, Xu; Liu, Yi; Lorthioir, Olivier; Martin, Matthew J.; McKerrecher, Darren; McWhirter, Claire; O'Neill, Daniel; Orme, Jonathan P.; Mosallanejad, Arash; Rahi, Amar; Smith, Paul D.; Talbot, Verity; Ward, Richard A.; Wrigley, Gail; Wylot, Marta; Xue, Lin; Yao, Tieguang; Ye, Yang; Zhao, Xiliang
Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

奥希替尼与其他EGFR tki的血脑屏障通透性的临床前比较

CLINICAL CANCER RESEARCH
IF10.2
2021-01-04130
OAAI
Colclough, Nicola; Chen, Kan; Johnstrom, Peter; Strittmatter, Nicole; Yan, Yumei; Wrigley, Gail L.; Schou, Magnus; Goodwin, Richard; Varnas, Katarina; Adua, Sally J.; Zhao, Minghui; Nguyen, Don X.; Maglennon, Gareth; Barton, Peter; Atkinson, James; Zhang, Lin; Janefeldt, Annika; Wilson, Joanne; Smith, Aaron; Takano, Akihiro; Arakawa, Ryosuke; Kondrashov, Mikhail; Malmquist, Jonas; Revunov, Evgeny; Vazquez-Romero, Ana; Moein, Mohammad Mahdi; Windhorst, Albert D.; Karp, Natasha A.; Finlay, M. Raymond, V; Ward, Richard A.; Yates, James W. T.; Smith, Paul D.; Farde, Lars; Cheng, Zack; Cross, Darren A. E.
Comparative activity profiling of tyrosine kinase inhibitors (TKIs) against exon 20 insertions and the wild-type form of epidermal growth factor receptor (EGFR)
CANCER RESEARCH
IF16.6
2019-07-011
PRE
Ward, Richard A.; Bianco, Ambra; Colclough, Nicola; Cross, Darren; Cuomo, Emanuela M.; Finlay, M. Raymond V.; Fitzek, Martina; Floc'h, Nicolas; Gagrica, Sladjana; Hammond, Beverley; Martin, Matthew J.; McKerrecher, Darren; O'Neill, Daniel J.; Orme, Jonathan P.; Smith, Paul D.; Staniszewska, Anna D.; Urosevic, Jelena; Whalley, Nicky; Yates, James W.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-07-3154
OAAI
Karlin, Jeremy; Allen, Jasmine; Ahmad, Syed F.; Hughes, Gareth; Sheridan, Victoria; Odedra, Rajesh; Farrington, Paul; Cadogan, Elaine B.; Riches, Lucy C.; Garcia-Trinidad, Antonio; Thomason, Andrew G.; Patel, Bhavika; Vincent, Jennifer; Lau, Alan; Pike, Kurt G.; Hunt, Thomas A.; Sule, Amrita; Valerie, Nicholas C. K.; Biddlestone-Thorpe, Laura; Kahn, Jenna; Beckta, Jason M.; Mukhopadhyay, Nitai; Barlaam, Bernard; Degorce, Sebastien L.; Kettle, Jason; Colclough, Nicola; Wilson, Joanne; Smith, Aaron; Barrett, Ian P.; Zheng, Li; Zhang, Tianwei; Wang, Yingchun; Chen, Kan; Pass, Martin; Durant, Stephen T.; Valerie, Kristoffer
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2018-07-1326
OAAI
Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Colclough, Nicola; Dishington, Allan; Durant, Stephen; Goldberg, Kristin; Hassall, Lorraine A.; Hughes, Gareth D.; MacFaul, Philip A.; McGuire, Thomas M.; Pass, Martin; Patel, Anil; Pearson, Stuart; Petersen, Jens; Pike, Kurt G.; Robb, Graeme; Stratton, Natalie; Xin, Guohong; Zhai, Baochang
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models
SCIENCE ADVANCES
IF12.5
2018-06-01221
OAAI
Durant, Stephen T.; Zheng, Li; Wang, Yingchun; Chen, Kan; Zhang, Lingli; Zhang, Tianwei; Yang, Zhenfan; Riches, Lucy; Trinidad, Antonio G.; Fok, Jacqueline H. L.; Hunt, Tom; Pike, Kurt G.; Wilson, Joanne; Smith, Aaron; Colclough, Nicola; Reddy, Venkatesh Pilla; Sykes, Andrew; Janefeldt, Annika; Johnstrom, Peter; Varnas, Katarina; Takano, Akihiro; Ling, Stephanie; Orme, Jonathan; Stott, Jonathan; Roberts, Caroline; Barrett, Ian; Jones, Gemma; Roudier, Martine; Pierce, Andrew; Allen, Jasmine; Kahn, Jenna; Sule, Amrita; Karlin, Jeremy; Cronin, Anna; Chapman, Melissa; Valerie, Kristoffer; Illingworth, Ruth; Pass, Martin
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-04-23101
OAAI
Pike, Kurt G.; Barlaam, Bernard; Cadogan, Elaine; Campbell, Andrew; Chen, Yingxue; Colclough, Nicola; Davies, Nichola L.; de-Almeida, Camila; Degorce, Sebastien L.; Didelot, Myriam; Dishington, Allan; Ducray, Richard; Durant, Stephen T.; Hassall, Lorraine A.; Holmes, Jane; Hughes, Gareth D.; MacFaul, Philip A.; Mulholland, Keith R.; McGuire, Thomas M.; Ouvry, Gilles; Pass, Martin; Robb, Graeme; Stratton, Natalie; Wang, Zhenhua; Wilson, Joanne; Zhai, Baochang; Zhao, Kang; Al-Huniti, Nidal
AZD1390, a potent and selective orally bioavailable blood-brain barrier-penetrant ATM inhibitor, radiosensitizes and improves survival of orthotopic glioma and metastatic brain tumor models
MOLECULAR CANCER THERAPEUTICS
IF5.5
2018-01-013
PRE
Durant, Steve T.; Pike, Kurt G.; Colclough, Nicola; Riches, Lucy; Garcia-Trinidad, Antonio; Hunt, Thomas; Ling, Stephanie; Stott, Jonathan; Barrett, Ian; Zheng, Li; Wang, Yingchun; Chen, Kan; Zhang, Tianwei; Reddy, Venkatesh Pilla; Sykes, Andrew; Johnstrom, Peter; Jones, Gemma; Pierce, Andrew; Karlin, Jeremy; Kahn, Jenna; Allen, Jasmine; Valerie, Kristoffer; Illingworth, Ruth; Pass, Martin

研究方向

暂未获取到该数据
R
Richard A. Ward
H 指数:51论文数:308被引数:1.0万
D
Darren A.E. Cross
H 指数:38论文数:217被引数:1.5万
J
Jonathan P. Orme
H 指数:10论文数:59被引数:785
K
Kurt G. Pike
H 指数:24论文数:94被引数:2,060
M
M. Raymond V. Finlay
H 指数:25论文数:133被引数:5,709
M
Martin Pass
H 指数:26论文数:189被引数:4,233
N
Nicolas Floc’h
H 指数:17论文数:166被引数:1,737
P
Peter Johnström
H 指数:30论文数:123被引数:5,132
S
Stephen T. Durant
H 指数:25论文数:109被引数:3,313
D
Daniel O’Neill
H 指数:15论文数:57被引数:883