logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回
K

Koichi Iijima

National Center for Geriatrics and Gerontology

34H指数
163论文数
4.4K被引数
收录论文 25
发表时间
logo
Biomarker-related phospho-tau217 appears in synapses around Aβ plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer’s disease与生物标志物相关的磷酸化tau217在阿尔茨海默病前临床期的大脑皮层中，出现在Aβ斑块周围的突触上，早于tau缠结的出现。
errCell Reports
IF6.9
err2025-09-02
err0
errOAAI
errYu Hirota; Yasufumi Sakakibara; Maho Morishima; Terunori Sano; Manato Hara; Akira Arakawa; Masaki Takao; Shigeo Murayama; Yuko Saito; Michiko Sekiya; Koichi M. Iijima
err分享
err收藏
Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding A(3 plaques in a mouse model of Alzheimer's disease
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-11-01
err0
errOAAI
errSekiya, Michiko; Sakakibara, Yasufumi; Hirota, Yu; Ito, Naoki; Chikamatsu, Sachie; Takei, Kimi; Nishijima, Risa; Iijima, Koichi M.
err分享
err收藏
Alzheimer's Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2023-05-30
err4
errOAAI
errHirota, Yu; Sakakibara, Yasufumi; Takei, Kimi; Nishijima, Risa; Sekiya, Michiko; Iijima, Koichi M.
err分享
err收藏
Distinct brain pathologies associated with Alzheimer's disease biomarker-related phospho-tau 181 and phospho-tau 217 in App knock-in mouse models of amyloid-β amyloidosis在淀粉样 β 淀粉样变性的App敲入小鼠模型中，与阿尔茨海默病生物标志物相关的磷酸化tau 181和磷酸化tau 217相关的不同脑部病理
errBRAIN COMMUNICATIONS
IF4.5
err2022-11-06
err13
errOAAI
errHirota, Yu; Sakakibara, Yasufumi; Ibaraki, Kyoko; Takei, Kimi; Iijima, Koichi M.; Sekiya, Michiko
err分享
err收藏
Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis在淀粉样 β 淀粉样变性的App敲入小鼠模型中，去甲肾上腺素能蓝斑轴突的密度普遍降低
errJOURNAL OF ALZHEIMERS DISEASE
IF3.1
err2021-08-17
err11
errOAAI
errSakakibara, Yasufumi; Hirota, Yu; Ibaraki, Kyoko; Takei, Kimi; Chikamatsu, Sachie; Tsubokawa, Yoko; Saito, Takashi; Saido, Takaomi C.; Sekiya, Michiko; Iijima, Koichi M.
err分享
err收藏
Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease
errNEURON
IF15
err2021-01-01
err103
errOAAI
errWang, Minghui; Li, Aiqun; Sekiya, Michiko; Beckmann, Noam D.; Quan, Xiuming; Schrode, Nadine; Fernando, Michael B.; Yu, Alex; Zhu, Li; Cao, Jiqing; Lyu, Liwei; Horgusluoglu, Emrin; Wang, Qian; Guo, Lei; Wang, Yuan-Shuo; Neff, Ryan; Song, Won-Min; Wang, Erming; Shen, Qi; Zhou, Xianxiao; Ming, Chen; Ho, Seok-Man; Vatansever, Sezen; Kaniskan, H. Umit; Jin, Jian; Zhou, Ming-Ming; Ando, Kanae; Ho, Lap; Slesinger, Paul A.; Yue, Zhenyu; Zhu, Jun; Katsel, Pavel; Gandy, Sam; Ehrlich, Michelle E.; Fossati, Valentina; Noggle, Scott; Cai, Dongming; Haroutunian, Vahram; Iijima, Koichi M.; Schadt, Eric; Brennand, Kristen J.; Zhang, Bin
err分享
err收藏
Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-12-01
err26
errOAAI
errOba, Toshiya; Saito, Taro; Asada, Akiko; Shimizu, Sawako; Iijima, Koichi M.; Ando, Kanae
err分享
err收藏
Disruption of a RAC1-centred network is associated with Alzheimer's disease pathology and causes age-dependent neurodegeneration
errHUMAN MOLECULAR GENETICS
IF3.2
err2020-01-16
err31
errOAAI
errKikuchi, Masataka; Sekiya, Michiko; Hara, Norikazu; Miyashita, Akinori; Kuwano, Ryozo; Ikeuchi, Takeshi; Iijima, Koichi M.; Nakaya, Akihiro
err分享
err收藏
Cdk5 increases MARK4 activity and augments pathological tau accumulation and toxicity through tau phosphorylation at Ser262
errHUMAN MOLECULAR GENETICS
IF3.2
err2019-06-07
err32
errOAAI
errSaito, Taro; Oba, Toshiya; Shimizu, Sawako; Asada, Akiko; Iijima, Koichi M.; Ando, Kanae
err分享
err收藏
S6K/p70S6K1 protects against tau-mediated neurodegeneration by decreasing the level of tau phosphorylated at Ser262 in a Drosophila model of tauopathy
errNEUROBIOLOGY OF AGING
IF3.5
err2018-11-01
err8
PREAI
errChiku, Tomoki; Hayashishita, Motoki; Saito, Taro; Oka, Mikiko; Shinno, Kanako; Ohtake, Yosuke; Shimizu, Sawako; Asada, Akiko; Hisanaga, Shin-ichi; Iijima, Koichi M.; Ando, Kanae
err分享
err收藏
Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila
errPLOS GENETICS
IF3.7
err2018-01-22
err37
errOAAI
errSakakibara, Yasufumi; Sekiya, Michiko; Fujisaki, Naoki; Quan, Xiuming; Iijima, Koichi M.
err分享
err收藏
EDEM Function in ERAD Protects against Chronic ER Proteinopathy and Age-Related Physiological Decline in Drosophila
errDEVELOPMENTAL CELL
IF8.7
err2017-06-01
err25
errOAAI
errSekiya, Michiko; Maruko-Otake, Akiko; Hearn, Stephen; Sakakibara, Yasufumi; Fujisaki, Naoki; Suzuki, Emiko; Ando, Kanae; Iijima, Koichi M.
err分享
err收藏
Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity
errPLOS GENETICS
IF3.7
err2016-03-29
err94
errOAAI
errAndo, Kanae; Maruko-Otake, Akiko; Ohtake, Yosuke; Hayashishita, Motoki; Sekiya, Michiko; Iijima, Koichi M.
err分享
err收藏
Global Analysis of Phosphorylation of Tau by the Checkpoint Kinases Chk1 and Chk2 in vitro
errJOURNAL OF PROTEOME RESEARCH
IF3.6
err2013-04-26
err42
errOAAI
errMendoza, Jhoana; Sekiya, Michiko; Taniguchi, Taizo; Iijima, Koichi M.; Wang, Rong; Ando, Kanae
err分享
err收藏
Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
errHUMAN MOLECULAR GENETICS
IF3.2
err2010-05-12
err99
errOAAI
errIijima, Koichi; Gatt, Anthony; Iijima-Ando, Kanae
err分享
err收藏
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration
errHUMAN MOLECULAR GENETICS
IF3.2
err2010-02-16
err60
errOAAI
errIijima-Ando, Kanae; Zhao, LiJuan; Gatt, Anthony; Shenton, Christopher; Iijima, Koichi
err分享
err收藏
JNK/FOXO-mediated Neuronal Expression of Fly Homologue of Peroxiredoxin II Reduces Oxidative Stress and Extends Life Span
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2009-10-01
err126
errOAAI
errLee, Kyu-Sun; Iijima-Ando, Kanae; Iijima, Koichi; Lee, Won-Jae; Lee, Joon H.; Yu, Kweon; Lee, Dong-Seok
err分享
err收藏
Distinctive roles of different β-amyloid 42 aggregates in modulation of synaptic functions
errFASEB JOURNAL
IF4.2
err2009-03-02
err34
errOAAI
errChiang, Hsueh-Cheng; Iijima, Koichi; Hakker, Inessa; Zhong, Yi
err分享
err收藏
Overexpression of neprilysin reduces Alzheimer amyloid-β42 (Aβ42)-induced neuron loss and intraneuronal Aβ42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2008-07-01
err80
errOAAI
errIijima-Ando, Kanae; Hearn, Stephen A.; Granger, Linda; Shenton, Christopher; Gatt, Anthony; Chiang, Hsueh-Cheng; Hakker, Inessa; Zhong, Yi; Iijima, Koichi
err分享
err收藏
cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in DrosophilacAMP反应元件结合蛋白和热休克蛋白70可额外抑制果蝇中多谷氨酰胺介导的毒性
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2005-07-11
err35
errOAAI
errIijima-Andot, K; Wu, P; Drier, EA; Iijima, K; Yin, JCP
err分享
err收藏

研究方向

暂时未获取到该数据
合作学者
合作期刊
E
Eric E. Schadt
H 指数: 134 · 论文数: 800
T
Takaomi C. Saido
H 指数: 112 · 论文数: 820
V
Vahram Haroutunian
H 指数: 107 · 论文数: 584
Bin Zhang 封面图
Bin Zhang (Bin Zhang)
H 指数: 93 · 论文数: 597
S
Sam Gandy
H 指数: 90 · 论文数: 499
查看更多