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Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model Michaels, Samantha A.; Shih, Han-Wei; Zhang, Bailin; Navaluna, Edelmar D.; Zhang, Zhongsheng; Ranade, Ranae M.; Gillespie, J. Robert; Merritt, Ethan A.; Fan, Erkang; Buckner, Frederick S.; Paredez, Alexander R.; Ojo, Kayode K. 分享 收藏
A Combined Approach Reveals a Regulatory Mechanism Coupling Src's Kinase Activity, Localization, and Phosphotransferase-Independent Functions Ahler, Ethan; Register, Ames C.; Chakraborty, Sujata; Fang, Linglan; Dieter, Emily M.; Sitko, Katherine A.; Vidadala, Rama Subba Rao; Trevillian, Bridget M.; Golkowski, Martin; Gelman, Hannah; Stephany, Jason J.; Rubin, Alan F.; Merritt, Ethan A.; Fowler, Douglas M.; Maly, Dustin J. 分享 收藏
Screening of the Pathogen Box for inhibitors with dual efficacy against Giardia lamblia and Cryptosporidium parvum Hennessey, Kelly M.; Rogiers, Ilse C.; Shih, Han-Wei; Hulverson, Matthew A.; Choi, Ryan; McCloskey, Molly C.; Whitman, Grant R.; Barrett, Lynn K.; Merritt, Ethan A.; Paredez, Alexander R.; Ojo, Kayode K. 分享 收藏
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays 弓形虫钙依赖性蛋白激酶1抑制剂: 使用细胞热位移测定法探测活性和抗性 Scheele, Suzanne; Geiger, Jennifer A.; DeRocher, Amy E.; Choi, Ryan; Smith, Tess R.; Hulverson, Matthew A.; Vidadala, Rama Subba Rao; Barrett, Lynn K.; Maly, Dustin J.; Merritt, Ethan A.; Ojo, Kayode K.; Van Voorhis, Wesley C.; Parsons, Marilyn 分享 收藏
7H-Pyrrolo[2,3-d]pyrimidin-4-amine-Based Inhibitors of Calcium- Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1H-Pyrazolo[3,4-d]pyrimidin-4-amine-Based Inhibitors Vidadala, Rama S. R.; Golkowski, Martin; Hulverson, Matthew A.; Choi, Ryan; McCloskey, Molly C.; Whitman, Grant R.; Huang, Wenlin; Arnold, Samuel L. M.; Barrett, Lynn K.; Fan, Erkang; Merritt, Ethan A.; Van Voorhis, Wesley C.; Ojo, Kayode K.; Maly, Dustin J. 分享 收藏
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Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis Vidadala, Rama Subba Rao; Rivas, Kasey L.; Ojo, Kayode K.; HuIverson, Matthew A.; Zambriski, Jennifer A.; Bruzual, Igor; Schultz, Tracey L.; Huang, Wenlin; Zhang, Zhongsheng; Scheele, Suzanne; DeRocher, Amy E.; Choi, Ryan; Barrett, Lynn K.; Siddaramaiah, Latha Kallur; Hol, Wim G. J.; Fan, Erkang; Merritt, Ethan A.; Parsons, Marilyn; Freiberg, Gail; Marsh, Kennan; Kempf, Dale J.; Carruthers, Vern B.; Isoherranen, Nina; Doggett, J. Stone; Van Voorhis, Wesley C.; Maly, Dustin J. 分享 收藏
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1 Huang, Wenlin; Ojo, Kayode K.; Zhang, Zhongsheng; Rivas, Kasey; Vidadala, Rama Subba Rao; Scheele, Suzanne; DeRocher, Amy E.; Choi, Ryan; Hulverson, Matthew A.; Barrett, Lynn K.; Bruzual, Igor; Siddaramaiah, Latha Kallur; Kerchner, Keshia M.; Kurnick, Matthew D.; Freiberg, Gail M.; Kempf, Dale; Hol, Wim G. J.; Merritt, Ethan A.; Neckermann, Georg; de Hostos, Eugenio L.; Isoherranen, Nina; Maly, Dustin J.; Parsons, Marilyn; Doggett, J. Stone; Van Voorhis, Wesley C.; Fang, Erkang 分享 收藏
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that the transmission of malaria to mosquitoes Vidadala, Rama Subba Rao; Ojo, Kayode K.; Johnson, Steven M.; Zhang, Zhongsheng; Leonard, Stephen E.; Mitra, Arinjay; Choi, Ryan; Reid, Molly C.; Keyloun, Katelyn R.; Fox, Anna M. W.; Kennedy, Mark; Silver-Brace, Tiffany; Hume, Jen C. C.; Kappe, Stefan; Verlinde, Christophe L. M. J.; Fan, Erkang; Merritt, Ethan A.; Van Voorhis, Wesley C.; Maly, Dustin J. 分享 收藏
Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold Zhang, Zhongsheng; Ojo, Kayode K.; Vidadala, RamaSubbaRao; Huang, Wenlin; Geiger, Jennifer A.; Scheele, Suzanne; Choi, Ryan; Reid, Molly C.; Keyloun, Katelyn R.; Rivas, Kasey; Siddaramaiah, Latha Kallur; Comess, Kenneth M.; Robinson, Kenneth P.; Merta, Philip J.; Kifle, Lemma; Hol, Wim G. J.; Parsons, Marilyn; Merritt, Ethan A.; Maly, Dustin J.; Verlinde, Christophe L. M. J.; Van Voorhis, Wesley C.; Fan, Erkang 分享 收藏
Affinity-Based Probes Based on Type II Kinase Inhibitors (vol 134, pg 19017, 2012) Ranjitkar, Pratistha; Perera, B. Gayani K.; Swaney, Danielle L.; Hari, Sanjay B.; Larson, Eric T.; Krishnamurty, Ratika; Merritt, Ethan A.; Villen, Judit; Maly, Dustin J. 分享 收藏
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Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors Ojo, Kayode K.; Pfander, Claudia; Mueller, Natascha R.; Burstroem, Charlotte; Larson, Eric T.; Bryan, Cassie M.; Fox, Anna M. W.; Reid, Molly C.; Johnson, Steven M.; Murphy, Ryan C.; Kennedy, Mark; Mann, Henning; Leibly, David J.; Hewitt, Stephen N.; Verlinde, Christophe L. M. J.; Kappe, Stefan; Merritt, Ethan A.; Maly, Dustin J.; Billker, Oliver; Van Voorhis, Wesley C. 分享 收藏
Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1 Larson, Eric T.; Ojo, Kayode K.; Murphy, Ryan C.; Johnson, Steven M.; Zhang, Zhongsheng; Kim, Jessica E.; Leibly, David J.; Fox, Anna M. W.; Reid, Molly C.; Dale, Edward J.; Perera, B. Gayani K.; Kim, Jae; Hewitt, Stephen N.; Hol, Wim G. J.; Verlinde, Christophe L. M. J.; Fan, Erkang; Van Voorhis, Wesley C.; Maly, Dustin J.; Merritt, Ethan A. 分享 收藏
Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity Johnson, Steven M.; Murphy, Ryan C.; Geiger, Jennifer A.; DeRocher, Amy E.; Zhang, Zhongsheng; Ojo, Kayode K.; Larson, Eric T.; Perera, B. Gayani K.; Dale, Edward J.; He, Panqing; Reid, Molly C.; Fox, Anna M. W.; Mueller, Natascha R.; Merritt, Ethan A.; Fan, Erkang; Parsons, Marilyn; Van Voorhis, Wesley C.; Maly, Dustin J. 分享 收藏
Screening a fragment cocktail library using ultrafiltration 使用超滤筛选片段鸡尾酒库 Shibata, Sayaka; Zhang, Zhongsheng; Korotkov, Konstantin V.; Delarosa, Jaclyn; Napuli, Alberto; Kelley, Angela M.; Mueller, Natasha; Ross, Jennifer; Zucker, Frank H.; Buckner, Frederick S.; Merritt, Ethan A.; Verlinde, Christophe L. M. J.; Van Voorhis, Wesley C.; Hol, Wim G. J.; Fan, Erkang 分享 收藏
Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice Shibata, Sayaka; Gillespie, J. Robert; Kelley, Angela M.; Napuli, Alberto J.; Zhang, Zhongsheng; Kovzun, Kuzma V.; Pefley, Ranae M.; Lam, Jocelyn; Zucker, Frank H.; Van Voorhis, Wesley C.; Merritt, Ethan A.; Hol, Wim G. J.; Verlinde, Christophe L. M. J.; Fan, Erkang; Buckner, Frederick S. 分享 收藏
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate 利什曼原虫主要甲硫氨酰-tRNA合成酶与中间产物甲硫氨酰腺苷酸和焦磷酸的复合物的结构 Larson, Eric T.; Kim, Jessica E.; Zucker, Frank H.; Kelley, Angela; Mueller, Natascha; Napuli, Alberto J.; Verlinde, Christophe L. M. J.; Fan, Erkang; Buckner, Frederick S.; Van Voorhis, Wesley C.; Merritt, Ethan A.; Hol, Wim G. J. 分享 收藏
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