Christopher E. Hart - Publications, H-index & Citations

Christopher E. Hart

Eli Lilly and Company

16H指数

42论文数

1.6K被引数

收录论文 17

发表时间

Longitudinal characterization of clinical, developmental, and behavioral phenotypes in 101 children and adults with FOXG1 syndrome 对101名FOXG1综合征患儿及成人的临床、发育及行为表型的纵向特征分析

Journal of Neurodevelopmental Disorders

IF4

2025-10-26

OAAI

Elise Brimble; Pam Ventola; Elizabeth Blomenberg; Kelsey Frahlich; Kopika Kuhathaas; Christopher E. Hart; Nadia Bahi-Buisson; Heather E. Olson; Eric D. Marsh; Gai Ayalon

A Workflow for Transcriptome-Wide Assessment of Antisense Oligonucleotide Selectivity 一种用于全转录组范围评估反义寡核苷酸选择性的工作流程

nucleic acid therapeutics

IF4.7

2025-09-29

PREAI

Sagar S. Damle; Andy Watt; Steven Kuntz; Amanda Crutchfield; Emma Carlborg; Judy Webb; Clare Quirk; Dorde Relic; Scott Donovan; Christopher E. Hart; Frank Rigo

GOLGA8 increases bulk antisense oligonucleotide uptake and activity in mammalian cells GOLGA8增加哺乳动物细胞中大量反义寡核苷酸的摄取和活性

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2023-06-01

OAAI

McMahon, Moira A.; Rahdar, Meghdad; Mukhopadhyay, Swagatam; Bui, Huynh-Hoa; Hart, Christopher; Damle, Sagar; Courtney, Margo; Baughn, Michael W.; Cleveland, Don W.; Bennett, Frank

Antisense Oligonucleotides Targeting Jagged 1 Reduce House Dust Mite-induced Goblet Cell Metaplasia in the Adult Murine Lung 靶向Jagged 1的反义寡核苷酸可减少成年小鼠肺中尘螨诱导的杯状细胞化生

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

IF5.3

2020-07-01

PREAI

Carrer, Michele; Crosby, Jeff R.; Sun, Guizhen; Zhao, Chenguang; Damle, Sagar S.; Kuntz, Steven G.; Monia, Brett P.; Hart, Christopher E.; Grossman, Tamar R.

Antisense oligonucleotide treatment ameliorates IFN-γ-induced proteinuria in APOL1-transgenic mice

JCI INSIGHT

IF6.1

2019-06-20

OAAI

Aghajan, Mariam; Booten, Sheri L.; Althage, Magnus; Hart, Christopher E.; Ericsson, Anette; Maxvall, Ingela; Ochaba, Joseph; Menschik-Lundin, Angela; Hartleib, Judith; Kuntz, Steven; Gattis, Danielle; Ahlstrom, Christine; Watt, Andrew T.; Engelhardt, Jeffery A.; Monia, Brett P.; Magnone, Maria Chiara; Guo, Shuling

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index Ps-aso治疗剂的化学修饰减少了细胞蛋白结合并提高了治疗指数

NATURE BIOTECHNOLOGY

IF41.7

2019-04-29

220

PREAI

Shen, Wen; De Hoyos, Cheryl L.; Migawa, Michael T.; Vickers, Timothy A.; Sun, Hong; Low, Audrey; Bell, Thomas A., III; Rahdar, Meghdad; Mukhopadhyay, Swagatam; Hart, Christopher E.; Bell, Melanie; Riney, Stan; Murray, Susan F.; Greenlee, Sarah; Crooke, Rosanne M.; Liang, Xue-hai; Seth, Punit P.; Crooke, Stanley T.

A modular analysis of microglia gene expression, insights into the aged phenotype 小胶质细胞基因表达的模块化分析，对衰老表型的见解

BMC GENOMICS

IF3.7

2019-02-28

OAAI

Cho, Christine E.; Damle, Sagar S.; Wancewicz, Edward V.; Mukhopadhyay, Swagatam; Hart, Christopher E.; Mazur, Curt; Swayze, Eric E.; Kamme, Fredrik

HELM Software for Biopolymers

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2017-05-19

PREAI

Milton, Jeff; Zhang, Tianhong; Bellamy, Claire; Swayze, Eric; Hart, Christopher; Weisser, Markus; Hecht, Sabrina; Rotstein, Sergio

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

MOLECULAR THERAPY

IF12

2016-10-01

OAAI

Crooke, Stanley T.; Baker, Brenda F.; Kwoh, T. Jesse; Cheng, Wei; Schulz, Dan J.; Xia, Shuting; Salgado, Nelson; Bui, Huynh-Hoa; Hart, Christopher E.; Burel, Sebastien A.; Younis, Husam S.; Geary, Richard S.; Henry, Scott P.; Bhanot, Sanjay

The Cell Wall Arabinose-Deficient Arabidopsis thaliana Mutant murus5 Encodes a Defective Allele of REVERSIBLY GLYCOSYLATED POLYPEPTIDE2

PLANT PHYSIOLOGY

IF6.9

2016-05-23

OAAI

Dugard, Christopher K.; Mertz, Rachel A.; Rayon, Catherine; Mercadante, Davide; Hart, Christopher; Benatti, Matheus R.; Olek, Anna T.; SanMiguel, Phillip J.; Cooper, Bruce R.; Reiter, Wolf-Dieter; McCann, Maureen C.; Carpita, Nicholas C.

Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

NUCLEIC ACIDS RESEARCH

IF13.1

2016-04-29

OAAI

Lima, Walt F.; Murray, Heather M.; Damle, Sagar S.; Hart, Christopher E.; Hung, Gene; De Hoyos, Cheryl Li; Liang, Xue-Hai; Crooke, Stanley T.

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

NUCLEIC ACIDS RESEARCH

IF13.1

2015-11-08

156

OAAI

Burel, Sebastien A.; Hart, Christopher E.; Cauntay, Patrick; Hsiao, Jill; Machemer, Todd; Katz, Melanie; Watt, Andy; Bui, Huynh-hoa; Younis, Husam; Sabripour, Mahyar; Freier, Susan M.; Hung, Gene; Dan, Amy; Prakash, T. P.; Seth, Punit P.; Swayze, Eric E.; Bennett, C. Frank; Crooke, Stanley T.; Henry, Scott P.

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

NUCLEIC ACIDS RESEARCH

IF13.1

2014-11-14

151

OAAI

Wan, W. Brad; Migawa, Michael T.; Vasquez, Guillermo; Murray, Heather M.; Nichols, Josh G.; Gaus, Hans; Berdeja, Andres; Lee, Sam; Hart, Christopher E.; Lima, Walt F.; Swayze, Eric E.; Seth, Punit P.

Genome-wide identification and characterization of replication origins by deep sequencing

GENOME BIOLOGY

IF9.4

2012-04-24

OAAI

Xu, Jia; Yanagisawa, Yoshimi; Tsankov, Alexander M.; Hart, Christopher; Aoki, Keita; Kommajosyula, Naveen; Steinmann, Kathleen E.; Bochicchio, James; Russ, Carsten; Regev, Aviv; Rando, Oliver J.; Nusbaum, Chad; Niki, Hironori; Milos, Patrice; Weng, Zhiping; Rhind, Nicholas

Tobacco carcinogen-induced transformation of HBECs is associated with chromatin-mediated reprogramming of the epigenome

CANCER RESEARCH

IF16.6

2011-04-01

PREAI

Tellez, Carmen S.; Juri, Daniel E.; Van Neste, Leander; Hart, Christopher; Liu, Yushi; Do, Kieu; Picchi, Maria A.; Belinsky, Steven A.

A mathematical and computational framework for quantitative comparison and integration of large-scale gene expression data

NUCLEIC ACIDS RESEARCH

IF13.1

2005-04-28

OAAI

Hart, CE; Sharenbroich, L; Bornstein, BJ; Trout, D; King, B; Mjolsness, E; Wold, BJ