Neil Aronin - Publications, H-index & Citations

Neil Aronin

UMass Chan Medical School

74H指数

233论文数

2.4W被引数

收录论文 70

发表时间

Early reduction of myelin-associated glycoprotein at myelin membranes in Huntington's disease 亨廷顿病中髓鞘相关糖蛋白在髓鞘膜上的早期减少

Experimental Neurology

IF4.2

2026-08-27

PREAI

Adel Boudi; Ellen Sapp; Yvonnie Y. Li; Kai Shing; Kimberly Kegel-Gleason; Tiziana Petrozziello; Ghazaleh Sadri-Vakili; Neil Aronin; Marian DiFiglia; Xueyi Li

Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington’s disease pathogenesis in mice 通过RNAi阻断体细胞重复序列扩增和降低亨廷蛋白协同减轻亨廷顿病在小鼠中的病理发生

Science Translational Medicine

IF14.6

2026-08-12

PREAI

Jillian Belgrad; Ashley Summers; Christian Landles; Jonathan R. Greene; Samuel Hildebrand; Emily Knox; Ellen Sapp; Nozomi Yamada; Raymond Furgal; Rachael Miller; Georgina F. Osborne; Kathryn Chase; Eric Luu; Jason Freedman; Brianna Bramato; Nicholas McHugh; Israel Nnah; Vicky Benoit; Daniel O’Reilly; Paul Greer; Gillian P. Bates; Thomas F. Vogt; Ramee Lee; David Howland; Marian DiFiglia; Neil Aronin; Anastasia Khvorova

Lowering the HTT1a transcript as an effective therapy for Huntington’s disease in a knockin mouse model 降低HTT1a转录本作为亨廷顿病在敲入小鼠模型中的有效疗法

Science Translational Medicine

IF14.6

2026-03-18

PREAI

Aikaterini Smaragdi Papadopoulou; Julia Alterman; Christian Landles; Edward J. Smith; Faith Conroy; Jemima Phillips; Maria Canibano-Pico; Iulia M. Nita; Georgina F. Osborne; Arzo Iqbal; Sarah G. Aldous; Marie K. Bondulich; Casandra Gomez-Paredes; Kirupa Sathasivam; Daniel O’Reilly; Dimas Echeverria; Konstantin Bobkov; Jonathan R. Greene; Neil Aronin; Anastasia Khvorova; Gillian P. Bates

ESC derived human cortical neurons harboring the NACC1 c.892C > T p.R298W missense mutation exhibit molecular differences from controls that influence neuronal maturation ESC来源的人皮质神经元携带NACC1 c.892C > T p.R298W错义突变，与对照相比表现出影响神经元成熟的分子差异。

HUMAN MOLECULAR GENETICS

IF3.2

2025-09-01

PREAI

Deehan, Mark; Sapp, Ellen; Iwanowicz, Andrew; Kothuis, Josine; Weisman, Elizabeth; Liu, Sophia; Jones, Erin; Iuliano, Maria; Robertson, Riannon; Seeley, Connor; Li, Zhaozhi; Noori, Ayush; Li, Xueyi; Das, Sudeshna; Brodsky, Michael; Aronin, Neil; DiFiglia, Marian; Kegel-Gleason, Kimberly B.

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation 使用neoepitope抗体在鼠脑中检测到的突变亨廷蛋白外显子1蛋白：CAG重复扩展、MutS同源物3沉默和聚集的影响

Brain Communications

IF4.5

2025-09-01

OAAI

Ellen Sapp; Adel Boudi; Andrew Iwanowicz; Jillian Belgrad; Rachael Miller; Riannon Robertson; Daniel O’Reilly; Ken Yamada; Yunping Deng; Marion Joni; Xueyi Li; Kimberly Kegel-Gleason; Anastasia Khvorova; Anton Reiner; Neil Aronin; Marian DiFiglia

Intrastriatal Delivery of a Zinc Finger Protein Targeting the Mutant HTT Gene Allele Obviates Lipid Phenotypes in Brain and Plasma in Huntington's Disease Mice 纹状体内递送靶向突变HTT基因等位基因的锌指蛋白可消除亨廷顿病小鼠脑和血浆中的脂质表型

gene therapy

IF4

2025-08-03

PREAI

Andrew Iwanowicz; Adel Boudi; Connor Seeley; Ellen Sapp; Rachael Miller; Sophia Liu; Kathryn Chase; Kai Shing; Ana Rita Batista; Miguel Siena-Esteves; Neil Aronin; Marian DiFiglia; Kimberly B. Kegel-Gleason

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+and Mg2+in the formulation

MOLECULAR THERAPY NUCLEIC ACIDS

IF6.1

2024-12-01

OAAI

Miller, Rachael; Paquette, Joseph; Barker, Alexandra; Sapp, Ellen; McHugh, Nicholas; Bramato, Brianna; Yamada, Nozomi; Alterman, Julia; Echeveria, Dimas; Yamada, Ken; Watts, Jonathan; Anaclet, Christelle; DiFiglia, Marian; Khvorova, Anastasia; Aronin, Neil

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

NUCLEIC ACID THERAPEUTICS

IF4.7

2024-08-01

PREAI

Allen, Sarah; O'Reilly, Daniel; Miller, Rachael; Sapp, Ellen; Summers, Ashley; Paquette, Joseph; Moreno, Dimas Echeverria; Bramato, Brianna; McHugh, Nicholas; Yamada, Ken; Aronin, Neil; DiFiglia, Marian; Khvorova, Anastasia

Enhancing siRNA efficacy in vivo with extended nucleic acid backbones

NATURE BIOTECHNOLOGY

IF41.7

2024-08-01

PREAI

Yamada, Ken; Hariharan, Vignesh N.; Caiazzi, Jillian; Miller, Rachael; Ferguson, Chantal M.; Sapp, Ellen; Fakih, Hassan H.; Tang, Qi; Yamada, Nozomi; Furgal, Raymond C.; Paquette, Joseph D.; Biscans, Annabelle; Bramato, Brianna M.; Mchugh, Nicholas; Summers, Ashley; Lochmann, Clemens; Godinho, Bruno M. D. C.; Hildebrand, Samuel; Jackson, Samuel O.; Echeverria, Dimas; Hassler, Matthew R.; Alterman, Julia F.; Difiglia, Marian; Aronin, Neil; Khvorova, Anastasia

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system 可编程双靶向siRNA支架支持中枢神经系统中有效的两基因调节

NUCLEIC ACIDS RESEARCH

IF13.1

2024-05-10

OAAI

Belgrad, Jillian; Tang, Qi; Hildebrand, Sam; Summers, Ashley; Sapp, Ellen; Echeverria, Dimas; O'Reilly, Dan; Luu, Eric; Bramato, Brianna; Allen, Sarah; Cooper, David; Alterman, Julia; Yamada, Ken; Aronin, Neil; Difiglia, Marian; Khvorova, Anastasia

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease (may, 10.1016/j.ymthe.2023.05.006, 2023)

MOLECULAR THERAPY

IF12

2023-11-01

OAAI

O'Reilly, Daniel; Belgrad, Jillian; Ferguson, Chantal; Summers, Ashley; Sapp, Ellen; McHugh, Cassandra; Mathews, Ella; Boudi, Adel; Buchwald, Julianna; Ly, Socheata; Moreno, Dimas; Furgal, Raymond; Luu, Eric; Kennedy, Zachary; Hariharan, Vignesh; Monopoli, Kathryn; Yang, X. William; Carroll, Jeffery; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington's disease

MOLECULAR THERAPY

IF12

2023-06-01

OAAI

O 'Reilly, Daniel; Belgrad, Jillian; Ferguson, Chantal; Summers, Ashley; Sapp, Ellen; McHugh, Cassandra; Mathews, Ella; Boudi, Adel; Buchwald, Julianna; Ly, Socheata; Moreno, Dimas; Furgal, Raymond; Luu, Eric; Kennedy, Zachary; Hariharan, Vignesh; Monopoli, Kathryn; Yang, William; Carroll, Jeffery; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Li, Xueyi; Standley, Clive; Sapp, Ellen; Valencia, Antonio; Qin, Zheng-Hong; Kegel, Kimberly B.; Yoder, Jennifer; Comer-Tierney, Laryssa A.; Esteves, Miguel; Chase, Kathryn; Alexander, Jonathan; Masso, Nicholas; Sobin, Lindsay; Bellve, Karl; Tuft, Richard; Lifshitz, Lawrence; Fogarty, Kevin; Aronin, Neil; DiFiglia, Marian

Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains

BRAIN COMMUNICATIONS

IF4.5

2022-10-13

OAAI

Ly, Socheata; Didiot, Marie-Cecile; Ferguson, Chantal M.; Coles, Andrew H.; Miller, Rachael; Chase, Kathryn; Echeverria, Dimas; Wang, Feng; Sadri-Vakili, Ghazaleh; Aronin, Neil; Khvorova, Anastasia

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington's disease models

NATURE COMMUNICATIONS

IF15.7

2022-10-03

OAAI

Conroy, Faith; Miller, Rachael; Alterman, Julia F.; Hassler, Matthew R.; Echeverria, Dimas; Godinho, Bruno M. D. C.; Knox, Emily G.; Sapp, Ellen; Sousa, Jaquelyn; Yamada, Ken; Mahmood, Farah; Boudi, Adel; Kegel-Gleason, Kimberly; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia; Pfister, Edith L.

A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions

CELL REPORTS MEDICINE

IF10.6

2022-07-01

OAAI

Estrada-Zuniga, Cynthia M.; Cheng, Zi-Ming; Ethiraj, Purushoth; Guo, Qianjin; Gonzalez-Cantu, Hector; Adderley, Elaina; Lopez, Hector; Landry, Bethany N.; Zainal, Abir; Aronin, Neil; Ding, Yanli; Wang, Xiaojing; Aguiar, Ricardo C. T.; Dahia, Patricia L. M.

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset

JCI INSIGHT

IF6.1

2021-12-22

OAAI

Ferguson, Chantal M.; Godinho, Bruno M. D. C.; Alterman, Julia F.; Coles, Andrew H.; Hassler, Matthew; Echeverria, Dimas; Gilbert, James W.; Knox, Emily G.; Caiazzi, Jillian; Haraszti, Reka A.; King, Robert M.; Taghian, Toloo; Puri, Ajit; Moser, Richard P.; Gounis, Matthew J.; Aronin, Neil; Gray-Edwards, Heather; Khvorova, Anastasia

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity

NUCLEIC ACIDS RESEARCH

IF13.1

2021-11-25

OAAI

Yamada, Ken; Hildebrand, Samuel; Davis, Sarah M.; Miller, Rachael; Conroy, Faith; Sapp, Ellen; Caiazzi, Jillian; Alterman, Julia F.; Roux, Loic; Echeverria, Dimas; Hassler, Matthew R.; Pfister, Edith L.; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2020-10-13

OAAI

Armaiz-Pena, Gustavo; Flores, Shahida K.; Cheng, Zi-Ming; Zhang, Xhingyu; Esquivel, Emmanuel; Poullard, Natalie; Vaidyanathan, Anusha; Liu, Qianqian; Michalek, Joel; Santillan-Gomez, Alfredo A.; Liss, Michael; Ahmadi, Sara; Katselnik, Daniel; Maldonado, Enrique; Salgado, Sarimar Agosto; Jimenez, Camilo; Fishbein, Lauren; Hamidi, Oksana; Else, Tobias; Lechan, Ron; Tischler, Art S.; Benn, Diana E.; Dwight, Trisha; Clifton-Bligh, Rory; Sanso, Gabriela; Barontini, Marta; Vincent, Deepa; Aronin, Neil; Biondi, Bernadette; Koops, Maureen; Bowhay-Carnes, Elizabeth; Gimenez-Roqueplo, Anne-Paule; Alvarez-Eslava, Andrea; Bruder, Jan M.; Kitano, Mio; Burnichon, Nelly; Ding, Yanli; Dahia, Patricia L. M.

Huntington's Disease: Les Jeux Sont Faits?

Trends in Molecular Medicine

IF13.8

2020-10-01

PREAI

Pfister, Edith L.; Aronin, Neil

研究方向