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收藏Pharmacokinetics modulation in solid tumors through thrombin-embedded nanomedicine通过血栓素嵌入的纳米药物对实体瘤的药代动力学调控
Lin, Sheng; Zhang, Liuwei; Cui, Hongyan; Wang, Yue; Zheng, Yang; Hu, Jianhua; Li, Mingzhu; Wang, Wentao; Zhang, Shijia; Zhou, Kehui 分享 收藏 分享 收藏 分享 收藏 Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathyKong, Chunyan; Guo, Zhen; Liu, Fangyuan; Tang, Nan; Wang, Mingyu; Yang, Dan; Li, Chenfei; Yang, Zheng; Ma, Yulan; Wang, Pan; Tang, Qizhu 分享 收藏 Beyond MABEL: An Integrative Approach to First in Human Dose Selection of Immunomodulators by the Health and Environmental Sciences Institute (HESI) Immuno-Safety Technical Committee (ITC)Matsumoto, Mineo; Polli, Joseph Ryan; Swaminathan, Suresh K.; Datta, Kaushik; Kampershroer, Cris; Fortin, Marie C.; Salian-Mehta, Smita; Dave, Rutwij; Yang, Zheng; Arora, Payal; Hiura, Masanori; Suzuki, Mizuho; Brennan, Frank R.; Sathish, Jean 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group SurveyPetersson, Carl; Zhou, Xin; Berghausen, Joerg; Cebrian, David; Davies, Michael; DeMent, Kevin; Eddershaw, Peter; Riedmaier, Arian Emami; Leblanc, Alix F.; Manveski, Nenad; Marathe, Punit; Mavroudis, Panteleimon D.; McDougall, Robin; Parrott, Neil; Reichel, Andreas; Rotter, Charles; Tess, David; Volak, Laurie P.; Xiao, Guangqing; Yang, Zheng; Baker, James 分享 收藏 Highly Expressed Soluble Recombinant Anti-GFP VHHs in Escherichia coli via Optimized Signal Peptides, Strains, and Inducers通过优化的信号肽，菌株和诱导物在大肠杆菌中高度表达可溶性重组抗GFP vhhChao, Shuangying; Liu, Yuhang; Ding, Ning; Lin, Yue; Wang, Qian; Tan, Junwen; Li, Wei; Zheng, Yang; Hu, Xuejun; Li, Junming 分享 收藏 分享 收藏 Long-Acting Tumor-Activated Prodrug of a TGFβR InhibitorZhang, Yong; Parrish, Karen E.; Tortolani, David R.; Poss, Michael A.; Huang, Audris; Wan, Honghe; Purandare, Ashok, V; Donnell, Andrew F.; Kempson, James; Hou, Xiaoping; Pawluczyk, Joseph; Yip, Shiuhang; Luk, Emily; Raghavan, Nimmi; Swanson, Jesse; Smalley, James; Murtaza, Anwar; Yang, Zheng; Augustine-Rauch, Karen; Lombardo, Louis J.; Borzilleri, Robert 分享 收藏 Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug DesignGavai, Ashvinikumar, V; Norris, Derek; Delucca, George; Tortolani, David; Tokarski, John S.; Dodd, Dharmpal; O'Malley, Daniel; Zhao, Yufen; Quesnelle, Claude; Gill, Patrice; Vaccaro, Wayne; Tram Huynh; Ahuja, Vijay; Han, Wen-Ching; Mussari, Christopher; Harikrishnan, Lalgudi; Kamau, Muthoni; Poss, Michael; Sheriff, Steven; Yan, Chunhong; Marsilio, Frank; Menard, Krista; Wen, Mei-Li; Rampulla, Richard; Wu, Dauh-Rurng; Li, Jianqing; Zhang, Huiping; Li, Peng; Sun, Dawn; Yip, Henry; Traeger, Sarah C.; Zhang, Yingru; Mathur, Arvind; Zhang, Haiying; Huang, Christine; Yang, Zheng; Ranasinghe, Asoka; Everlof, Gerry; Raghavan, Nirmala; Tye, Ching Kim; Wee, Susan; Hunt, John T.; Vite, Gregory; Westhouse, Richard; Lee, Francis Y. 分享 收藏 Conformational-Analysis-Guided Discovery of 2,3-Disubstituted Pyridine IDO1 Inhibitors构象分析指导的2，3-二取代吡啶IDO1抑制剂的发现Cherney, Emily C.; Zhang, Liping; Guo, Weiwei; Huang, Audris; Williams, David; Seitz, Steven; Shan, Weifang; Zhu, Xiao; Gullo-Brown, Johnni; Maley, Derrick; Lin, Tai-an; Hunt, John T.; Huang, Christine; Yang, Zheng; D'Arienzo, Celia J.; Discenza, Lorell N.; Ranasinghe, Asoka; Grubb, Mary F.; Traeger, Sarah C.; Li, Xin; Johnston, Kathy A.; Kopcho, Lisa; Fereshteh, Mark; Foster, Kimberly A.; Stefanski, Kevin; Delpy, Diane; Dhar, Gopal; Anandam, Aravind; Mahankali, Sandeep; Padmanabhan, Shweta; Rajanna, Prabhakar; Murali, Venkata; Mariappan, T. Thanga; Pattasseri, Shabeerali; Nimje, Roshan Y.; Hong, Zhenqiu; Kempson, James; Rampulla, Richard; Mathur, Arvind; Gupta, Anuradha; Borzilleri, Robert; Vite, Gregory; Balog, Aaron 分享 收藏 Discovery and Preclinical Evaluation of BMS-986242, a Potent, Selective Inhibitor of Indoleamine-2,3-dioxygenase 1BMS-986242的发现和临床前评估，一种有效的，选择性的Indoleamine-2，3-双加氧酶1抑制剂Cherney, Emily C.; Zhang, Liping; Nara, Susheel; Zhu, Xiao; Gullo-Brown, Johnni; Maley, Derrick; Lin, Tai-An; Hunt, John T.; Huang, Christine; Yang, Zheng; Darienzo, Celia; Discenza, Lorell; Ranasinghe, Asoka; Grubb, Mary; Ziemba, Theresa; Traeger, Sarah C.; Li, Xin; Johnston, Kathy; Kopcho, Lisa; Fereshteh, Mark; Foster, Kimberly; Stefanski, Kevin; Fargnoli, Joseph; Swanson, Jesse; Brown, Jennifer; Delpy, Diane; Seitz, Steven P.; Borzilleri, Robert; Vite, Gregory; Balog, Aaron 分享 收藏 Catestatin attenuates endoplasmic reticulum induced cell apoptosis by activation type 2 muscarinic acetylcholine receptor in cardiac ischemia/reperfusion (vol 5, 16590, 2015)Liao, Feng; Zheng, Yang; Cai, Junyan; Fan, Jinghui; Wang, Jing; Yang, Jichun; Cui, Qinghua; Xu, Guoheng; Tang, Chaoshu; Geng, Bin 分享 收藏 Strategies and Recommendations for Using a Data-Driven and Risk-Based Approach in the Selection of First-in-Human Starting Dose: An International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) AssessmentLeach, Michael W.; Clarke, David O.; Dudal, Sherri; Han, Chao; Li, Chunze; Yang, Zheng; Brennan, Frank R.; Bailey, Wendy J.; Chen, Yingxue; Deslandes, Antoine; Loberg, Lise I.; Mayawala, Kapil; Rogge, Mark C.; Todd, Marque; Chemuturi, Nagendra V. 分享 收藏 
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