Michael J. Sutcliffe - Publications, H-index & Citations

Michael J. Sutcliffe

University of Manchester

58H指数

211论文数

1.0W被引数

收录论文 68

发表时间

Quantum Mechanics/Molecular Mechanics Studies on the Mechanism of Action of Cofactor Pyridoxal 5′-Phosphate in Ornithine 4,5-Aminomutase

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2014-07-22

OAAI

Pang, Jiayun; Scrutton, Nigel S.; Sutcliffe, Michael J.

Pressure Effects on Enzyme-Catalyzed Quantum Tunneling Events Arise from Protein-Specific Structural and Dynamic Changes

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2012-06-05

PREAI

Hay, Sam; Johannissen, Linus O.; Hothi, Parvinder; Sutcliffe, Michael J.; Scrutton, Nigel S.

Large-Scale Domain Conformational Change Is Coupled to the Activation of the Co-C Bond in the B12-Dependent Enzyme Ornithine 4,5-Aminomutase: A Computational Study

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2012-01-19

PREAI

Pang, Jiayun; Li, Xin; Morokuma, Keiji; Scrutton, Nigel S.; Sutcliffe, Michael J.

Temperature-dependent study reveals that dynamics of hydrophobic residues plays an important functional role in the mitochondrial Tim9-Tim10 complex

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

IF2.8

2011-11-17

PREAI

Ivanova, Ekaterina; Pang, Jiayun; Jowitt, Thomas A.; Yan, Guanhua; Warwicker, Jim; Sutcliffe, Michael J.; Lu, Hui

Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed 来自疟疾载体冈比亚按蚊的细胞色素P450 6M2代谢拟除虫菊酯: 溴氰菊酯的顺序代谢揭示

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

IF3.7

2011-07-01

215

PREAI

Stevenson, Bradley J.; Bibby, Jaclyn; Pignatelli, Patricia; Muangnoicharoen, Sant; O'Neill, Paul M.; Lian, Lu-Yun; Mueller, Pie; Nikou, Dimitra; Steven, Andrew; Hemingway, Janet; Sutcliffe, Michael J.; Paine, Mark J. I.

How Does Pressure Affect Barrier Compression and Isotope Effects in an Enzymatic Hydrogen Tunneling Reaction?

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2011-01-25

PREAI

Johannissen, Linus O.; Scrutton, Nigel S.; Sutcliffe, Michael J.

Direct Analysis of Donor Acceptor Distance and Relationship to Isotope Effects and the Force Constant for Barrier Compression in Enzymatic H-Tunneling Reactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2010-07-27

PREAI

Pudney, Christopher R.; Johannissen, Linus O.; Sutcliffe, Michael J.; Hay, Sam; Scrutton, Nigel S.

Protein-protein interactions

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2010-07-26

PREAI

Williamson, Mike P.; Sutcliffe, Michael J.

Barrier Compression and Its Contribution to Both Classical and Quantum Mechanical Aspects of Enzyme Catalysis

BIOPHYSICAL JOURNAL

IF3.1

2010-01-01

OAAI

Hay, Sam; Johannissen, Linus O.; Sutcliffe, Michael J.; Scrutton, Nigel S.

New insights into the multi-step reaction pathway of the reductive half-reaction catalysed by aromatic amine dehydrogenase: a QM/MM study

CHEMICAL COMMUNICATIONS

IF4.2

2010-01-01

PREAI

Pang, Jiayun; Scrutton, Nigel S.; de Visser, Sam P.; Sutcliffe, Michael J.

Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2009-11-05

PREAI

Pudney, Christopher R.; Hay, Sam; Levy, Colin; Pang, Jiayun; Sutcliffe, Michael J.; Leys, David; Scrutton, Nigel S.

Barrier Compression Enhances an Enzymatic Hydrogen-Transfer Reaction 屏障压缩增强了酶促氢转移反应

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2009-01-30

PREAI

Hay, Sam; Pudney, Christopher R.; McGrory, Tom A.; Pang, Jiayun; Sutcliffe, Michael J.; Scrutton, Nigel S.

Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions 从CYP2D6-drug相互作用的建模研究中了解细胞色素P450对药物代谢的见解

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-01-29

OAAI

Marechal, J-D; Kemp, C. A.; Roberts, G. C. K.; Paine, M. J. I.; Wolf, C. R.; Sutcliffe, M. J.

Receptor-selective TRAIL Mutants Target Lymphoid Tumor cells for Apoptosis via TRAIL-R1: Implications for Therapy

TOXICOLOGY

IF4.6

2008-11-01

OAAI

MacFarlane, Marion; Kohlhaas, Susan L.; Sutcliffe, Michael J.; Dyer, Martin J. S.; Cohen, Gerald M.

Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2008-07-01

OAAI

Roberts, Jonathan A.; Digby, Helen R.; Kara, Madina; El Ajouz, Sam; Sutcliffe, Michael J.; Evans, Richard J.

The enzyme aromatic amine dehydrogenase induces a substrate conformation crucial for promoting vibration that significantly reduces the effective potential energy barrier to proton transfer

JOURNAL OF THE ROYAL SOCIETY INTERFACE

IF3.5

2008-05-21

OAAI

Johannissen, Linus O.; Scrutton, Nigel S.; Sutcliffe, Michael J.

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2008-05-10

PREAI

Pang, Jiayun; Hay, Sam; Scrutton, Nigel S.; Sutcliffe, Michael J.

Atomistic insight into the origin of the temperature-dependence of kinetic isotope effects and H-tunnelling in enzyme systems is revealed through combined experimental studies and biomolecular simulation

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2008-01-22

PREAI

Hay, Sam; Pudney, Christopher; Hothi, Parvinder; Johannissen, Linus O.; Masgrau, Laura; Pang, Jiayun; Leys, David; Sutcliffe, Michael J.; Scrutton, Nigel S.

Are environmentally coupled enzymatic hydrogen tunneling reactions influenced by changes in solution viscosity?

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2007-12-21

PREAI

Hay, Sam; Pudney, Christopher R.; Sutcliffe, Michael J.; Scrutton, Nigel S.

Activation Gating of hERG potassium channels - S6 glycines are not required as gating hinges

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2007-11-01

OAAI

Hardman, Rachael M.; Stansfeld, Phillip J.; Dalibalta, Sarah; Sutcliffe, Michael J.; Mitcheson, John S.

研究方向