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收藏分享 收藏 分享 收藏 Translation of nonclinical to clinical safety findings for 27 biotherapeutics
Leach, Michael W.; Rana, Payal; Hu, Wenyue; Mittapalli, Rajendar K.; Pinkstaff, Jason; Potter, David; Qiu, Xing Min; Ramaiah, Lila; Rohde, Cynthia; Xia, Feng; Khan, K. Nasir 分享 收藏 分享 收藏 Melatonin alleviates Hg toxicity by modulating redox homeostasis and the urea cycle in mossHu, Wen-Yue; Mao, Hao-Tian; Yin, Xiao-Yan; Chen, Jing-Yi; He, An-Qi; Huang, Lin-Yan; Zhang, Zhong-Wei; Yuan, Shu; Yuan, Ming; Su, Yan-Qiu; Chen, Yang-Er 分享 收藏 Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilitiesYenerall, Paul; Sung, Tae; Palyada, Kiran; Qian, Jessie; Arat, Seda; Kumpf, Steven W.; Wang, Shih-Wen; Biddle, Kathleen; Esparza, Carlos; Chang, Stephanie; Scott, Wesley; Collette, Walter; Winrow, Taylor-Symon; Affolter, Tim; Shirai, Norimitsu; Thibault, Stephane; Wang, Julia; Liu, Ling; Bauchmann, Mary; Frey, Jessica; Steyn, Stefanus; Sacaan, Aida; Vitsky, Allison; Ahn, Youngwook; Paul, Tom; Lum, Lawrence; Oyer, Jon; Yang, Amy; Hu, Wenyue 分享 收藏 分享 收藏 Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational ToxicityHu, Wenyue; Lettiere, Daniel; Tse, Susanna; Johnson, Theodore R.; Biddle, Kathleen E.; Thibault, Stephane; Palazzi, Xavier; Chen, Joseph; Pithavala, Yazdi K.; Finkelstein, Martin 分享 收藏 分享 收藏 分享 收藏 分享 收藏 An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological ToxicityYeung, Yik Andy; Krishnamoorthy, Veena; Dettling, Danielle; Sommer, Cesar; Poulsen, Kris; Ni, Irene; Pham, Amber; Chen, Wei; Liao-Chan, Sindy; Lindquist, Kevin; Chin, S. Michael; Chunyk, Allison Given; Hu, Wenyue; Sasu, Barbra; Chaparro-Riggers, Javier; Djuretic, Ivana 分享 收藏 Intestinal Toxicity in Rats Following Administration of CDK4/6 Inhibitors Is Independent of Primary PharmacologyThibault, Stephane; Hu, Wenyue; Hirakawa, Brad; Kalabat, Dalia; Franks, Tania; Sung, Tae; Khoh-Reiter, Su; Lu, Shuyan; Finkelstein, Martin; Jessen, Bart; Sacaan, Aida 分享 收藏 Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)Kung, Pei-Pei; Bingham, Patrick; Brooun, Alexei; Collins, Michael; Deng, Ya-Li; Dinh, Dac; Fan, Connie; Gajiwala, Ketan S.; Grantner, Rita; Gukasyan, Hovhannes J.; Hu, Wenyue; Huang, Buwen; Kania, Robert; Kephart, Susan E.; Krivacic, Cody; Kumpf, Robert A.; Khamphavong, Penney; Kraus, Manfred; Liu, Wei; Maegley, Karen A.; Nguyen, Lisa; Ren, Shijian; Richter, Dan; Rollins, Robert A.; Sach, Neal; Sharma, Shikhar; Sherrill, John; Spangler, Jillian; Stewart, Albert E.; Sutton, Scott; Uryu, Sean; Verhelle, Dominique; Wang, Hui; Wang, Shuiwang; Wythes, Martin; Xin, Shuibo; Yamazaki, Shinji; Zhu, Huichun; Zhu, JinJiang; Zehnder, Luke; Edwards, Martin 分享 收藏 Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors (vol 59, pg 8306, 2016)Kung, Pei-Pei; Rui, Eugene; Bergqvist, Simon; Bingham, Patrick; Braganza, John; Collins, Michael; Cui, Mei; Diehl, Wade; Dinh, Dac; Fan, Connie; Fantin, Valeria R.; Gukasyan, Hovhannes J.; Hu, Wenyue; Huang, Buwen; Kephart, Susan; Krivacic, Cody; Kumpf, Robert A.; Li, Gary; Maegley, Karen A.; McAlpine, Indrawan; Nguyen, Lisa; Ninkovic, Sacha; Ornelas, Martha; Ryskin, Michael; Scales, Stephanie; Sutton, Scott; Tatlock, John; Verhelle, Dominique; Wang, Fen; Wells, Peter; Wythes, Martin; Yamazaki, Shinji; Yip, Brian; Yu, Xiu; Zehnder, Luke; Zhang, Wei-Guo; Rollins, Robert A.; Edwards, Martin 分享 收藏 Spectrum and Degree of CDK Drug Interactions Predicts Clinical PerformanceChen, Ping; Lee, Nathan V.; Hu, Wenyue; Xu, Meirong; Ferre, Rose Ann; Lam, Hieu; Bergqvist, Simon; Solowiej, James; Diehl, Wade; He, You-Ai; Yu, Xiu; Nagata, Asako; VanArsdale, Todd; Murray, Brion W. 分享 收藏 Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) InhibitorsKung, Pei-Pei; Rui, Eugene; Bergqvist, Simon; Bingham, Patrick; Braganza, John; Collins, Michael; Cui, Mei; Diehl, Wade; Dac Dinh; Fan, Connie; Fantin, Valeria R.; Gukasyan, Hovhannes J.; Hu, Wenyue; Huang, Buwen; Kephart, Susan; Krivacic, Cody; Kumpf, Robert A.; Li, Gary; Maegley, Karen A.; McAlpine, Indrawan; Nguyen, Lisa; Ninkovic, Sacha; Ornelas, Martha; Ryskin, Michael; Scales, Stephanie; Sutton, Scott; Tatlock, John; Verhelle, Dominique; Wang, Fen; Wells, Peter; Wythes, Martin; Yamazaki, Shinji; Yip, Brian; Yu, Xiu; Zehnder, Luke; Zhang, Wei-Guo; Rollins, Robert A.; Edwards, Martin 分享 收藏 PF-06463922, a novel next generation ALK/ROS1 inhibitor, overcomes resistance to 1st and 2nd generation ALK inhibitors in pre-clinical modelsFriboulet, Luc; Zou, Helen; Kodack, David P.; Engstrom, Lars D.; Li, Qiuhua; West, Melissa; Tang, Ruth W.; Wang, Hui; Tsaparikos, Konstantinos; Wang, Jinwei; Timofeevski, Sergei; Dinh, Dac M.; Hieu Lam; Lam, Justine L.; Yamazaki, Shinji; Hu, Wenyue; Patel, Bhushankumar; Bezwada, Divya; Mahmood, Sidra; Lifshits, Eugene; Affolter, Timothy; Lappin, Patrick B.; Gukasyan, Hovhannes; Lee, Nathan; Deng, Shibing; Jain, Rakesh K.; Johnson, Ted W.; Shaw, Alice T.; Fantin, Valeria R.; Smeal, Tod 分享 收藏 分享 收藏 
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