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M

Mariano Barbacid

centro nacional de investigaciones oncológicas
H指数:120
被引数:6.6万

个人简介

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荣誉奖项

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FAK inhibitor and RAF/MEK clamp avutometinib enhance KRAS G12C inhibitor efficacy in preclinical models of non–small cell lung cancer

FAK抑制剂和RAF/MEK夹具avutometinib增强KRAS G12C抑制剂在非小细胞肺癌预临床模型中的疗效

Science Translational Medicine
IF14.6
2026-09-300
PRE
Silvia Coma; Monica Musteanu; Cristina Caffarra Malvezzi; Ryan R. Jamieson; Enrico Patrucco; Alessia Mira; Julien Dilly; Ziyue Li; Ana Fernández-Rodríguez; Alejandra López-García; Andrew J. Aguirre; Mariano Barbacid; Chiara Ambrogio; Jonathan A. Pachter
Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

肺癌和卵巢癌对铂类化疗的治疗耐药性是由可靶向的tgf β 衰老分泌蛋白驱动的

Nature Aging
IF19.4
2026-02-030
OAAI
Estela González-Gualda; Marika A. V. Reinius; David Macias; Samir Morsli; Jianfeng Ge; Ioana Olan; José Ezequiel Martín; Hui-Ling Ou; Muhamad Hartono; María Pilar Puerto-Camacho; Mary Denholm; Rosalind Kieran; Reuben Hoffmann; Mark Dane; Dimitris Veroutis; Guillermo Medrano; Francisca Mulero; Mercedes Jimenez-Linan; Ljiljana Fruk; Carla P. Martins; Mariano Barbacid; Vassilis Gorgoulis; James E. Korkola; Doris M. Rassl; Gary J. Doherty; Robert C. Rintoul; Masashi Narita; James D. Brenton; Daniel Muñoz-Espín
T Cell-Specific Inactivation of the PI3K p110α Catalytic Subunit: Effect in T Cell Differentiation and Antigen-Specific Responses

T细胞特异性失活PI3K p110α催化亚基：对T细胞分化和抗原特异性反应的影响

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
IF4.9
2025-01-120
OA
Briones, Alejandro C.; del Estal, Laura; Villa-Gomez, Cristina; Bermejo, Veronica; Cervera, Isabel; Gutierrez-Huerta, Pedro; Montes-Casado, Maria; Ortega, Sagrario; Barbacid, Mariano; Rojo, Jose Maria; Portoles, Pilar
Type I interferon signaling pathway enhances immune- checkpoint inhibition in KRAS mutant lung tumors

I型干扰素信号通路增强KRAS突变型肺肿瘤的免疫检查点抑制

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2024-08-260
PRE
Fernandez-Garcia, Fernando; Fernandez-Rodriguez, Ana; Fustero-Torre, Coral; Pineiro-Yanez, Elena; Wang, Haiyun; Lechuga, Carmen G.; Callejas, Sergio; Alvarez, Rebeca; Lopez-Garcia, Alejandra; Esteban-Burgos, Laura; Salmon, Marina; San Roman, Marta; Guerra, Carmen; Ambrogio, Chiara; Drosten, Matthias; Santamaria, David; Al Shahrour, Fatima; Dopazo, Ana; Barbacid, Mariano; Musteanu, Monica
Enabling biomarkers of chromosomal instability for tumor only targeted gene panel sequencing
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Gomez-Sanchez, David; Thompson, Joe Sneath; Hernando, Barbara; Garcia-Lopez, Diego; de Galard, Hector; Roy, Abhipsa; Cullen, Amy; Madrid, Laura; Teles, Jose; Piskorz, Ania; Yip, Jason; Cadiz, Alice; Escobar-Rey, Maria; Moreno-Vellisca, Roberto; Carrizo, Nuria; Alvarez, Eva; Quintela-Fandino, Miguel; Barbacid, Mariano; Ramos-Paradas, Javier; Coya, Juan Manuel; Ferrer, Irene; Zugazagoitia, Jon; Paz-Ares, Luis; MacIntyre, Geoff
Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer
NATURE COMMUNICATIONS
IF15.7
2023-10-109
OAAI
Macaya, Irati; Roman, Marta; Welch, Connor; Entrialgo-Cadierno, Rodrigo; Salmon, Marina; Santos, Alba; Feliu, Iker; Kovalski, Joanna; Lopez, Ines; Rodriguez-Remirez, Maria; Palomino-Echeverria, Sara; Lonfgren, Shane M.; Ferrero, Macarena; Calabuig, Silvia; Ludwig, Iziar A.; Lara-Astiaso, David; Jantus-Lewintre, Eloisa; Guruceaga, Elizabeth; Narayanan, Shruthi; Ponz-Sarvise, Mariano; Pineda-Lucena, Antonio; Lecanda, Fernando; Ruggero, Davide; Khatri, Purvesh; Santamaria, Enrique; Fernandez-Irigoyen, Joaquin; Ferrer, Irene; Paz-Ares, Luis; Drosten, Matthias; Barbacid, Mariano; Gil-Bazo, Ignacio; Vicent, Silve
A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
CANCER RESEARCH
IF16.6
2023-04-040
PRE
Gonzalez-Gualda, Estela; Macias, David; Morsli, Samir; Martin, Jose Ezequiel; Ou, Hui-Ling; Denholm, Mary; Olan, Ioana; Hoffmann, Reuben; Dane, Mark; Veroutis, Dimitris; Medrano, Guillermo; Mulero, Francisca; Martins, Carla P.; Barbacid, Mariano; Gorgoulis, Vassilis; Korkola, James E.; Rassl, Doris M.; Doherty, Gary J.; Rintoul, Robert C.; Narita, Masashi; Munoz-Espin, Daniel
Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas
JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2023-04-0316
OAAI
Salmon, Marina; Alvarez-Diaz, Ruth; Fustero-Torre, Coral; Brehey, Oksana; Lechuga, Carmen G.; Sanclemente, Manuel; Fernandez-Garcia, Fernando; Lopez-Garcia, Alejandra; Martin-Guijarro, Maria Carmen; Rodriguez-Perales, Sandra; Bousquet-Mur, Emily; Morales-Cacho, Lucia; Mulero, Francisca; Al-Shahrour, Fatima; Martinez, Lola; Dominguez, Orlando; Caleiras, Eduardo; Ortega, Sagrario; Guerra, Carmen; Musteanu, Monica; Drosten, Matthias; Barbacid, Mariano
Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-02-224
OAAI
Janssen, Kobe; Claes, Filip; Van de Velde, Dido; Wehbi, Vanessa L.; Houben, Bert; Lampi, Yulia; Nys, Mieke; Khodaparast, Laleh; Khodaparast, Ladan; Louros, Nikolaos; van der Kant, Rob; Verniers, Joffre; Garcia, Teresa; Ramakers, Meine; Konstantoulea, Katerina; Maragkou, Katerina; Duran-Romana, Ramon; Musteanu, Monica; Barbacid, Mariano; Scorneaux, Bernard; Beirnaert, Els; Schymkowitz, Joost; Rousseau, Frederic

研究方向

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G
Guerra, Carmen
H 指数:0论文数:2被引数:28
M
Matthias Drosten
H 指数:26论文数:74被引数:3,180
M
Marcos Malumbres
H 指数:74论文数:365被引数:3.0万
D
David Santamarı́a
H 指数:30论文数:95被引数:5,009
M
Mónica Musteanu
H 指数:20论文数:76被引数:1,791
S
Sagrario Ortega
H 指数:53论文数:136被引数:1.3万
C
Carmen G. Lechuga
H 指数:16论文数:73被引数:1,150
F
Francisca Mulero
H 指数:33论文数:123被引数:5,110
P
Pierre Dubus
H 指数:51论文数:287被引数:1.3万
C
Chiara Ambrogio
H 指数:40论文数:216被引数:5,138