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Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader 发现一种强效且高选择性的蛋白质精氨酸甲基转移酶5 (PRMT5) PROTAC降解剂 Zhong, Yue; Kim, Huensuk; Qian, Chao; Xie, Ling; Chen, Xian; Xiong, Yan; Hu, Jacqueline; Chen, Matthew; Guccione, Ernesto; Shen, Yudao 分享 收藏
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Hepatovirus translation requires PDGFA-associated protein 1, an eIF4E-binding protein regulating endoplasmic reticulum stress responses Shirasaki, Takayoshi; Lenarcic, Erik; Misumi, Ichiro; Xie, Ling; Fusco, William G.; Yonish, Bryan; Das, Anshuman; Kim, Hyejeong; Cameron, Craig E.; Leger-Abraham, Melissa; Chen, Xian; Cullen, John M.; Whitmire, Jason K.; Li, You; Duncan, Joseph A.; Moorman, Nathaniel J.; Lemon, Stanley M. 分享 收藏
NEAT1 repression by MED12 creates chemosensitivity in p53 wild-type breast cancer cells MED12抑制NEAT1在p53野生型乳腺癌细胞中产生化学敏感性 Zhang, Shengjie; Kim, Eui-Jun; Huang, Junfeng; Liu, Peng; Donahue, Kristine; Wang, Qinchuan; Wang, Yidan; Mcilwain, Sean; Xie, Ling; Chen, Xian; Li, Lingjun; Xu, Wei 分享 收藏
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation 组蛋白甲基转移酶G9a在慢性炎症翻译调控中的非经典功能 Muneer, Adil; Wang, Li; Xie, Ling; Zhang, Feng; Wu, Bing; Mei, Liu; Lenarcic, Erik M.; Feng, Emerald Hillary; Song, Juan; Xiong, Yan; Yu, Xufen; Wang, Charles; Jain, Kanishk; Strahl, Brian D.; Cook, Jeanette Gowen; Wan, Yisong Y.; Moorman, Nathaniel John; Song, Hongjun; Jin, Jian; Chen, Xian 分享 收藏
Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer Yu, Xufen; Li, Dongxu; Kottur, Jithesh; Kim, Huen Suk; Herring, Laura E.; Yu, Yao; Xie, Ling; Hu, Xiaoping; Chen, Xian; Cai, Ling; Liu, Jing; Aggarwal, Aneel K.; Wang, Gang Greg; Jin, Jian 分享 收藏
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Design, Synthesis, and Evaluation of Potent, Selective, and Bioavailable AKT Kinase Degraders 强效、选择性和生物可利用的AKT激酶降解剂的设计、合成和评价 Yu, Xufen; Xu, Jia; Xie, Ling; Wang, Li; Shen, Yudao; Cahuzac, Kaitlyn M.; Chen, Xian; Liu, Jing; Parsons, Ramon E.; Jin, Jian 分享 收藏
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Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation 利用E3连接酶KEAP1进行靶向蛋白质降解 Wei, Jieli; Meng, Fanye; Park, Kwang-Su; Yim, Hyerin; Velez, Julia; Kumar, Prashasti; Wang, Li; Xie, Ling; Chen, He; Shen, Yudao; Teichman, Emily; Li, Dongxu; Wang, Gang Greg; Chen, Xian; Kaniskan, H. Umit; Jin, Jian 分享 收藏
The G2A Receptor Deficiency Aggravates Atherosclerosis in Rats by Regulating Macrophages and Lipid Metabolism Cui, Xueqin; Xing, Roumei; Tian, Yue; Wang, Man; Sun, Yue; Xu, Yongqian; Yang, Yiqing; Zhao, Yongliang; Xie, Ling; Xiao, Yufang; Li, Dali; Zheng, Biao; Liu, Mingyao; Chen, Huaqing 分享 收藏
Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders 一流蛋白精氨酸甲基转移酶5 (PRMT5) 降解剂的发现 Shen, Yudao; Gao, Guozhen; Yu, Xufen; Kim, Huensuk; Wang, Li; Xie, Ling; Schwarz, Megan; Chen, Xian; Guccione, Ernesto; Liu, Jing; Bedford, Mark T.; Jin, Jian 分享 收藏
Dual base editor catalyzes both cytosine and adenine base conversions in human cells Zhang, Xiaohui; Zhu, Biyun; Chen, Liang; Xie, Ling; Yu, Weishi; Wang, Ying; Li, Linxi; Yin, Shuming; Yang, Lei; Hu, Handan; Han, Honghui; Li, Yongmei; Wang, Liren; Chen, Geng; Ma, Xueyun; Geng, Hongquan; Huang, Wanfeng; Pang, Xiufeng; Yang, Zuozhen; Wu, Yuxuan; Siwko, Stefan; Kurita, Ryo; Nakamura, Yukio; Yang, Li; Liu, Mingyao; Li, Dali 分享 收藏
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Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants (vol 9, pg 814, 2018) Yang, Lei; Zhang, Xiaohui; Wang, Liren; Yin, Shuming; Zhu, Biyun; Xie, Ling; Duan, Qiuhui; Hu, Huiqiong; Zheng, Rui; Wei, Yu; Peng, Liangyue; Han, Honghui; Zhang, Jiqin; Qiu, Wenjuan; Geng, Hongquan; Siwko, Stefan; Zhang, Xueli; Liu, Mingyao; Li, Dali 分享 收藏
Proteogenomic integration reveals therapeutic targets in breast cancer xenografts (vol 8, 14864, 2017) 蛋白质基因组整合揭示乳腺癌异种移植物的治疗靶点 (第8卷，14864，2017) Huang, Kuan-lin; Li, Shunqiang; Mertins, Philipp; Cao, Song; Gunawardena, Harsha P.; Ruggles, Kelly V.; Mani, D. R.; Clauser, Karl R.; Tanioka, Maki; Usary, Jerry; Kavuri, Shyam M.; Xie, Ling; Yoon, Christopher; Qiao, Jana W.; Wrobel, John; Wyczalkowski, Matthew A.; Erdmann-Gilmore, Petra; Snider, Jacqueline E.; Hoog, Jeremy; Singh, Purba; Niu, Beifang; Guo, Zhanfang; Sun, Sam Qiancheng; Sanati, Souzan; Kawaler, Emily; Wang, Xuya; Scott, Adam; Ye, Kai; McLellan, Michael D.; Wendl, Michael C.; Malovannaya, Anna; Held, Jason M.; Gillette, Michael A.; Fenyo, David; Kinsinger, Christopher R.; Mesri, Mehdi; Rodriguez, Henry; Davies, Sherri R.; Perou, Charles M.; Ma, Cynthia; Townsend, R. Reid; Chen, Xian; Carr, Steven A.; Ellis, Matthew J.; Ding, Li 分享 收藏
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