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收藏A humanized minipig model for the toxicological testing of therapeutic recombinant antibodies用于治疗性重组抗体毒理学测试的人源化小型猪模型
Flisikowska, Tatiana; Egli, Jerome; Flisikowski, Krzysztof; Stumbaum, Marlene; Kueng, Erich; Ebeling, Martin; Schmucki, Roland; Georges, Guy; Singer, Thomas; Kurome, Mayuko; Kessler, Barbara; Zakhartchenko, Valeri; Wolf, Eckhard; Weber, Felix; Schnieke, Angelika; Iglesias, Antonio 分享 收藏 Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodiesKerns, S. Jordan; Belgur, Chaitra; Petropolis, Debora; Kanellias, Marianne; Barrile, Riccardo; Sam, Johannes; Weinzierl, Tina; Fauti, Tanja; Freimoser-Grundschober, Anne; Eckmann, Jan; Hage, Carina; Geiger, Martina; Ng, Patrick Ray; Tien-Street, William; Manatakis, Dimitris, V; Micallef, Virginie; Gerard, Regine; Bscheider, Michael; Breous-Nystrom, Ekaterina; Schneider, Anneliese; Giusti, Anna Maria; Bertinetti-Lapatki, Cristina; Grant, Heather Shannon; Roth, Adrian B.; Hamilton, Geraldine A.; Singer, Thomas; Karalis, Katia; Moisan, Annie; Bruenker, Peter; Klein, Christian; Bacac, Marina; Gjorevski, Nikolce; Cabon, Lauriane 分享 收藏 Managing the impact of immunogenicity in an era of immunotherapy: from bench to bedside在免疫治疗时代管理免疫原性的影响: 从工作台到床边Bray-French, Katharine; Hartman, Katharina; Steiner, Guido; Marban-Doran, CSeline; Bessa, Juliana; Campbell, Neil; Martin-Facklam, Meret; Stubenrauch, Kay-Gunnar; Solier, Corinne; Singer, Thomas; Ducret, Axel 分享 收藏 Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligenceMaloca, Peter M.; Mueller, Philipp L.; Lee, Aaron Y.; Tufail, Adnan; Balaskas, Konstantinos; Niklaus, Stephanie; Kaiser, Pascal; Suter, Susanne; Zarranz-Ventura, Javier; Egan, Catherine; Scholl, Hendrik P. N.; Schnitzer, Tobias K.; Singer, Thomas; Hasler, Pascal W.; Denk, Nora 分享 收藏 Enabling Routine MHC-II-Associated Peptide Proteomics for Risk Assessment of Drug-Induced Immunogenicity (vol 19, pg 3792, 2020)Steiner, Guido; Marban-Doran, Celine; Langer, Jessica; Pimenova, Tatiana; Duran-Pacheco, Gonzalo; Sauter, Denise; Langenkamp, Anja; Solier, Corinne; Singer, Thomas; Bray-French, Katharine; Ducret, Axel 分享 收藏 分享 收藏 Enabling Routine MHC-II-Associated Peptide Proteomics for Risk Assessment of Drug-Induced ImmunogenicitySteiner, Guido; Marban-Doran, Celine; Langer, Jessica; Pimenova, Tatiana; Duran-Pacheco, Gonzalo; Sauter, Denise; Langenkamp, Anja; Solier, Corinne; Singer, Thomas; Bray-French, Katharine; Ducret, Axel 分享 收藏 Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic RiskDavies, Mark R.; Martinec, Michael; Walls, Robert; Schwarz, Roman; Mirams, Gary R.; Wang, Ken; Steiner, Guido; Surinach, Andy; Flores, Carlos; Lave, Thierry; Singer, Thomas; Polonchuk, Liudmila 分享 收藏 分享 收藏 General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico StrategyLi, Zhihua; Mirams, Gary R.; Yoshinaga, Takashi; Ridder, Bradley J.; Han, Xiaomei; Chen, Janell E.; Stockbridge, Norman L.; Wisialowski, Todd A.; Damiano, Bruce; Severi, Stefano; Morissette, Pierre; Kowey, Peter R.; Holbrook, Mark; Smith, Godfrey; Rasmusson, Randall L.; Liu, Michael; Song, Zhen; Qu, Zhilin; Leishman, Derek J.; Steidl-Nichols, Jill; Rodriguez, Blanca; Bueno-Orovio, Alfonso; Zhou, Xin; Passini, Elisa; Edwards, Andrew G.; Morotti, Stefano; Ni, Haibo; Grandi, Eleonora; Clancy, Colleen E.; Vandenberg, Jamie; Hill, Adam; Nakamura, Mikiko; Singer, Thomas; Polonchuk, Liudmila; Greiter-Wilke, Andrea; Wang, Ken; Nave, Stephane; Fullerton, Aaron; Sobie, Eric A.; Paci, Michelangelo; Tshinanu, Flora Musuamba; Strauss, David G. 分享 收藏 分享 收藏 First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils首次输注反应由fc γ riiib和中性粒细胞介导Weber, Felix; Breustedt, Daniel; Schlicht, Sonja; Meyer, Claas A.; Niewoehner, Jens; Ebeling, Martin; Freskgard, Per-Ola; Bruenker, Peter; Singer, Thomas; Reth, Michael; Iglesias, Antonio 分享 收藏 分享 收藏 Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding ModeWeber, Felix; Bohrmann, Bernd; Niewoehner, Jens; Fischer, Jens A. A.; Rueger, Petra; Tiefenthaler, Georg; Moelleken, Joerg; Bujotzek, Alexander; Brady, Kevin; Singer, Thomas; Ebeling, Martin; Iglesias, Antonio; Freskard, Per-Ola 分享 收藏 Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug DiscoveryDrawnel, Faye Marie; Zhang, Jitao David; Kung, Erich; Aoyama, Natsuyo; Benmansour, Fethallah; Del Rosario, Andrea Araujo; Zoffmann, Sannah Jensen; Delobel, Frederic; Prummer, Michael; Weibel, Franziska; Carlson, Coby; Anson, Blake; Iacone, Roberto; Certa, Ulrich; Singer, Thomas; Ebeling, Martin; Prunotto, Marco 分享 收藏 分享 收藏 Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety ProfilingMoisan, Annie; Gubler, Marcel; Zhang, Jitao David; Tessier, Yann; Erichsen, Kamille Dumong; Sewing, Sabine; Gerard, Regine; Avignon, Blandine; Huber, Sylwia; Benmansour, Fethallah; Chen, Xing; Villasenor, Roberto; Braendli-Baiocco, Annamaria; Festag, Matthias; Maunz, Andreas; Singer, Thomas; Schuler, Franz; Roth, Adrian B. 分享 收藏 Application of Imaging Techniques to Cases of Drug-Induced Crystal Nephropathy in Preclinical StudiesLenz, Barbara; Brink, Andreas; Siam, Monira; De Paepe, Anne; Bassett, Simon; Eichinger-Chapelon, Anne; Maliver, Pierre; Neff, Rachel; Niederhauser, Urs; Steinhuber, Bernd; Zurbach, Raphael; Singer, Thomas; Funk, Christoph; Schuler, Franz; Albassam, Mudher; Schadt, Simone 分享 收藏 The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides在单链寡核苷酸的安全性评估中，小型猪是合适的非啮齿动物模型Braendli-Baiocco, Annamaria; Festag, Matthias; Erichsen, Kamille Dumong; Persson, Robert; Mihatsch, Michael J.; Fisker, Niels; Funk, Juergen; Mohr, Susanne; Constien, Rainer; Ploix, Corinne; Brady, Kevin; Berrera, Marco; Altmann, Bernd; Lenz, Barbara; Albassam, Mudher; Schmitt, Georg; Weiser, Thomas; Schuler, Franz; Singer, Thomas; Tessier, Yann 分享 收藏 
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