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Andrew W. Stamford

merck & company
H指数:36
被引数:3,947

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Recruitment of FBXO22 for targeted degradation of NSD2

招募FBXO22靶向降解NSD2

NATURE CHEMICAL BIOLOGY
IF13.7
2024-07-047
PRE
Nie, David Y.; Tabor, John R.; Li, Jianping; Kutera, Maria; St-Germain, Jonathan; Hanley, Ronan P.; Wolf, Esther; Paulakonis, Ethan; Kenney, Tristan M. G.; Duan, Shili; Shrestha, Suman; Owens, Dominic D. G.; Maitland, Matthew E. R.; Pon, Ailing; Szewczyk, Magdalena; Lamberto, Anthony Joseph; Menes, Michael; Li, Fengling; Penn, Linda Z.; Barsyte-Lovejoy, Dalia; Brown, Nicholas G.; Barsotti, Anthony M.; Stamford, Andrew W.; Collins, Jon L.; Wilson, Derek J.; Raught, Brian; Licht, Jonathan D.; James, Lindsey I.; Arrowsmith, Cheryl H.
Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia
CANCER DISCOVERY
IF33.3
2022-09-0234
OAAI
Liu, Yiman; Li, Qinglan; Alikarami, Fatemeh; Barrett, Declan R.; Mahdavi, Leila; Li, Hangpeng; Tang, Sylvia; Khan, Tanweer A.; Michino, Mayako; Hill, Connor; Song, Lele; Yang, Lu; Li, Yuanyuan; Pokharel, Sheela Pangeni; Stamford, Andrew W.; Liverton, Nigel; Renzetti, Louis M.; Taylor, Simon; Watt, Gillian F.; Ladduwahetty, Tammy; Kargman, Stacia; Meinke, Peter T.; Foley, Michael A.; Shi, Junwei; Li, Haitao; Carroll, Martin; Chen, Chun-Wei; Gardini, Alessandro; Maillard, Ivan; Huggins, David J.; Bernt, Kathrin M.; Wan, Liling
Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
CANCER RESEARCH
IF16.6
2021-02-2527
OA
Singh, Kamini; Lin, Jianan; Lecomte, Nicolas; Mohan, Prathibha; Gokce, Askan; Sanghvi, Viraj R.; Jiang, Man; Grbovic-Huezo, Olivera; Burcul, Antonija; Stark, Stefan G.; Romesser, Paul B.; Chang, Qing; Melchor, Jerry P.; Beyer, Rachel K.; Duggan, Mark; Fukase, Yoshiyuki; Yang, Guangli; Ouerfelli, Ouathek; Viale, Agnes; de Stanchina, Elisa; Stamford, Andrew W.; Meinke, Peter T.; Raetsch, Gunnar; Leach, Steven D.; Ouyang, Zhengqing; Wendel, Hans-Guido
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions
ACS INFECTIOUS DISEASES
IF3.8
2021-02-023
OAAI
Ginn, John; Jiang, Xiuju; Sun, Shan; Michino, Mayako; Huggins, David J.; Mbambo, Zodwa; Jansen, Robert; Rhee, Kyu Y.; Arango, Nancy; Lima, Christopher D.; Liverton, Nigel; Imaeda, Toshihiro; Okamoto, Rei; Kuroita, Takanobu; Aso, Kazuyoshi; Stamford, Andrew; Foley, Michael; Meinke, Peter T.; Nathan, Carl; Bryk, Ruslana
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
NATURE COMMUNICATIONS
IF15.7
2019-05-21180
OAAI
Lama, Lodoe; Adura, Carolina; Xie, Wei; Tomita, Daisuke; Kamei, Taku; Kuryavyi, Vitaly; Gogakos, Tasos; Steinberg, Joshua I.; Miller, Michael; Ramos-Espiritu, Lavoisier; Asano, Yasutomi; Hashizume, Shogo; Aida, Jumpei; Imaeda, Toshihiro; Okamoto, Rei; Jennings, Andy J.; Michino, Mayako; Kuroita, Takanobu; Stamford, Andrew; Gao, Pu; Meinke, Peter; Glickman, J. Fraser; Patel, Dinshaw J.; Tuschl, Thomas
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-11-0210
PREAI
Mandal, Mihirbaran; Mitra, Kaushik; Grotz, Diane; Lin, Xinjie; Palamanda, Jairam; Kumari, Pramila; Buevich, Alexei; Caldwell, John P.; Chen, Xia; Cox, Kathleen; Favreau, Leonard; Hyde, Lynn; Kennedy, Matthew E.; Kuvelkar, Reshma; Liu, Xiaoxian; Mazzola, Robert D.; Parker, Eric; Rindgen, Diane; Sherer, Edward; Wang, Hongwu; Zhu, Zhaoning; Stamford, Andrew W.; Cumming, Jared N.
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2017-11-2137
OAAI
Bungard, Christopher J.; Williams, Peter D.; Schulz, Jurgen; Wiscount, Catherine M.; Holloway, M. Katharine; Loughran, H. Marie; Manikowski, Jesse J.; Su, Hua-Poo; Bennett, David J.; Chang, Lehua; Chu, Xin-Jie; Crespo, Alejandro; Dwyer, Michael P.; Keertikar, Kartik; Morriello, Gregori J.; Stamford, Andrew W.; Waddell, Sherman T.; Zhong, Bin; Hu, Bin; Jo, Tao; Diamond, Tracy L.; Bahnck-Teets, Carolyn; Carroll, Steven S.; Fay, John F.; Min, Xu; Morris, William; Ballard, Jeanine E.; Miller, Michael D.; McCauley, John A.
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-03-16113
PREAI
Scott, Jack D.; DeMong, Duane E.; Greshock, Thomas J.; Basu, Kallol; Dai, Xing; Harris, Joel; Hruza, Alan; Li, Sarah W.; Lin, Sue-Ing; Liu, Hong; Macala, Megan K.; Hu, Zhiyong; Mei, Hong; Zhang, Honglu; Walsh, Paul; Poirier, Marc; Shi, Zhi-Cai; Xiao, Li; Agnihotri, Gautam; Baptista, Marco A. S.; Columbus, John; Fell, Matthew J.; Hyde, Lynn A.; Kuvelkar, Reshma; Lin, Yinghui; Mirescu, Christian; Morrow, John A.; Yin, Zhizhang; Zhang, Xiaoping; Zhou, Xiaoping; Chang, Ronald K.; Embrey, Mark W.; Sanders, John M.; Tiscia, Heather E.; Drolet, Robert E.; Kern, Jonathan T.; Sur, Sylvie M.; Renger, John J.; Bilodeau, Mark T.; Kennedy, Matthew E.; Parker, Eric M.; Stamford, Andrew W.; Nargund, Ravi; McCauley, John A.; Miller, Michael W.
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-11-18133
OAAI
Scott, Jack D.; Li, Sarah W.; Brunskill, Andrew P. J.; Chen, Xia; Cox, Kathleen; Cumming, Oared N.; Forman, Mark; Gilbert, Eric J.; Hodgson, Robert A.; Hyde, Lynn A.; Jiang, Qin; Iserloh, Ulrich; Kazakevich, Irina; Kuvelkar, Reshma; Mei, Hong; Meredith, John; Misiaszek, Jeffrey; Orth, Peter; Rossiter, Lana M.; Slater, Meagan; Stone, Julie; Strickland, Corey O.; Voigt, Johannes H.; Wang, Ganfeng; Wang, Hongwu; Wu, Yusheng; Greenlee, William J.; Parker, Eric M.; Kennedy, Matthew E.; Stamford, Andrew W.
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2016-11-02354
PREAI
Kennedy, Matthew E.; Stamford, Andrew W.; Chen, Xia; Cox, Kathleen; Cumming, Jared N.; Dockendorf, Marissa F.; Egan, Michael; Ereshefsky, Larry; Hodgson, Robert A.; Hyde, Lynn A.; Jhee, Stanford; Kleijn, Huub J.; Kuvelkar, Reshma; Li, Wei; Mattson, Britta A.; Mei, Hong; Palcza, John; Scott, Jack D.; Tanen, Michael; Troyer, Matthew D.; Tseng, Jack L.; Stone, Julie A.; Parker, Eric M.; Forman, Mark S.
Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-03-2239
PREAI
Mandal, Mihirbaran; Wu, Yusheng; Misiaszek, Jeffrey; Li, Guoqing; Buevich, Alexei; Caldwell, John P.; Liu, Xiaoxiang; Mazzola, Robert D.; Orth, Peter; Strickland, Corey; Voigt, Johannes; Wang, Hongwu; Zhu, Zhaoning; Chen, Xia; Grzelak, Michael; Hyde, Lynn A.; Kuvelkar, Reshma; Leach, Prescott T.; Terracina, Giuseppe; Zhang, Lili; Zhang, Qi; Michener, Maria S.; Smith, Brad; Cox, Kathleen; Grotz, Diane; Favreau, Leonard; Mitra, Kaushik; Kazakevich, Irina; McKittrick, Brian A.; Greenlee, William; Kennedy, Matthew E.; Parker, Eric M.; Cumming, Jared N.; Stamford, Andrew W.
Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2015-07-1314
OAAI
Liu, Ping; Hu, Zhiyong; DuBois, Byron G.; Moyes, Christopher R.; Hunter, David N.; Zhu, Cheng; Kar, Nam Fung; Zhu, Yuping; Garfunkle, Joie; Kang, Ling; Chicchi, Gary; Ehrhardt, Anka; Woods, Andrea; Seo, Toru; Woods, Morgan; van Heek, Margaret; Dingley, Karen H.; Pang, Jianmei; Salituro, Gino M.; Powell, Joyce; Terebetski, Jenna L.; Hornak, Viktor; Campeau, Louis-Charles; Lamberson, Joe; Ujjainwalla, Fez; Miller, Michael; Stamford, Andrew; Wood, Harold B.; Kowalski, Timothy; Nargund, Ravi P.; Edmondson, Scott D.
The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-02-2617
PREAI
DeMong, Duane; Dai, Xing; Hwa, Joyce; Miller, Michael; Lin, Sue-Ing; Kang, Ling; Stamford, Andrew; Greenlee, William; Yu, Wensheng; Wong, Michael; Lavey, Brian; Kozlowski, Joseph; Zhou, Guowei; Yang, De-Yi; Patel, Bhuneshwari; Soriano, Aileen; Zhai, Ying; Sondey, Christopher; Zhang, Hongtao; Lachowicz, Jean; Grotz, Diane; Cox, Kathleen; Morrison, Richard; Andreani, Teresa; Cao, Yang; Liang, Mark; Meng, Tao; McNamara, Paul; Wong, Jesse; Bradley, Prudence; Feng, Kung-I; Belani, Jitendra; Chen, Ping; Dai, Peng; Gauuan, Jolicia; Lin, Peishan; Zhao, He

研究方向

暂未获取到该数据
E
Eric M. Parker
H 指数:49论文数:191被引数:7,389
W
William J. Greenlee
H 指数:42论文数:226被引数:7,128
M
Matthew Kennedy
H 指数:35论文数:149被引数:5,119
R
Reshma Kuvelkar
H 指数:17论文数:39被引数:1,720
P
Peter T. Meinke
H 指数:40论文数:207被引数:6,296
J
Jared N. Cumming
H 指数:30论文数:86被引数:3,564
K
Kathleen Cox
H 指数:34论文数:96被引数:3,924
L
Lynn A. Hyde
H 指数:33论文数:122被引数:3,966
J
Johannes Voigt
H 指数:32论文数:96被引数:2,881
C
Corey Strickland
H 指数:22论文数:95被引数:2,314