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NCP, a Dual Kappa and Mu Opioid Receptor Agonist, Is a Potent Analgesic Against Inflammatory Pain without Reinforcing or Aversive Properties Huang, Peng; Ho, Conrad K.; Cao, Danni; Inan, Saadet; Rawls, Scott M.; Li, Mengchu; Huang, Boshi; Pagare, Piyusha P.; Townsend, E. Andrew; Poklis, Justin L.; Halquist, Matthew S.; Banks, Matthew; Zhang, Yan; Liu-Chen, Lee-Yuan 分享 收藏
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Structural Alterations of the Address Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity Ma, Hongguang; Pagare, Piyusha P.; Li, Mengchu; Neel, Logan T.; Mendez, Rolando E.; Gillespie, James C.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan 分享 收藏
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues Li, Mengchu; Stevens, David L.; Arriaga, Michelle; Townsend, E. Andrew; Mendez, Rolando E.; Blajkevch, Nadejda A.; Selley, Dana E.; Banks, Matthew L.; Negus, S. Stevens; Dewey, William L.; Zhang, Yan 分享 收藏
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists Pagare, Piyusha P.; Li, Mengchu; Zheng, Yi; Kulkarni, Abhishek S.; Obeng, Samuel; Huang, Boshi; Ruiz, Christian; Gillespie, James C.; Mendez, Rolando E.; Stevens, David L.; Poklis, Justin L.; Halquist, Matthew S.; Dewey, William L.; Selley, Dana E.; Zhang, Yan 分享 收藏
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment 外周选择性 μ 阿片受体配体作为潜在阿片类药物诱导便秘治疗的合理设计、化学合成和生物学评价 Huang, Boshi; Li, Mengchu; Klongkumnuankarn, Pornprom; Mendez, Rolando E.; Gillespie, James C.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan 分享 收藏
Fabrication of 2D Metal-Organic Framework Nanosheets with Highly Colloidal Stability and High Yield through Coordination Modulation 通过配位调制制备高胶体稳定性和高产率的二维金属有机骨架纳米片 Zhou, Huazhang; Zhang, Liying; Wang, Guizhou; Zhang, Yichi; Wang, Xuanhe; Li, Mengchu; Fan, Fuqiang; Li, Yunong; Wang, Tieqiang; Zhang, Xuemin; Fu, Yu 分享 收藏
Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity 基于结构的设计和开发靶向假定的MOR-CCR5异二聚体的化学探针，以抑制阿片类药物加剧的HIV-1感染性 Huang, Boshi; Wang, Huiqun; Zheng, Yi; Li, Mengchu; Kang, Guifeng; Barreto-de-Souza, Victor; Nassehi, Nima; Knapp, Pamela E.; Selley, Dana E.; Hauser, Kurt F.; Zhang, Yan 分享 收藏
Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry 针对阿片类药物增强HIV-1进入的假定 μ 阿片受体和趋化因子受体CXCR4二聚体的二价配体 Ma, Hongguang; Wang, Huiqun; Li, Mengchu; Barreto-de-Souza, Victor; Reinecke, Bethany A.; Gunta, Rama; Zheng, Yi; Kang, Guifeng; Nassehi, Nima; Zhang, Huijun; An, Jing; Selley, Dana E.; Hauser, Kurt F.; Zhang, Yan 分享 收藏
Comparison of Pharmacological Properties between the Kappa Opioid Receptor Agonist Nalfurafine and 42B, Its 3-Dehydroxy Analogue: Disconnect between in Vitro Agonist Bias and in Vivo Pharmacological Effects 比较Kappa阿片受体激动剂Nalfurafine和42B，其3-脱羟基类似物之间的药理特性: 体外激动剂偏倚和体内药理作用之间的脱节 Cao, Danni; Huang, Peng; Chiu, Yi-Ting; Chen, Chongguang; Wang, Huiqun; Li, Mengchu; Zheng, Yi; Ehlert, Frederick J.; Zhang, Yan; Liu-Chen, Lee-Yuan 分享 收藏
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators Ma, Hongguang; Obeng, Samuel; Wang, Huiqun; Zheng, Yi; Li, Mengchu; Jali, Abdulmajeed M.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan 分享 收藏
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