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O

Ondřej Soukup

university hospital hradec kralove

41H指数
247论文数
5.4K被引数
收录论文 128
发表时间
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Development of Novel 17β-HSD10 Inhibitors and Their Evaluation in an In Vitro Model of Alzheimer’s Disease新型17β-HSD10抑制剂的研发及其在阿尔茨海默病体外模型中的评价
errACS Medicinal Chemistry Letters
IF4
err2026-05-18
err0
PREAI
errMarketa Sedlacek Miskerikova; Aneta Houfkova; Marketa Benkova; Rudolf Andrys; Jiri Janousek; Ondrej Soukup; Kamil Musilek; Ondrej Benek
err分享
err收藏
Reactivation screening of A-234-inhibited human recombinant acetylcholinesterase in vitroA-234抑制的人重组乙酰胆碱酯酶的体外重激活筛选
errChemico-Biological Interactions
IF5.4
err2025-11-04
err0
PREAI
errJakub Opravil; Jaroslav Pejchal; Martina Hrabinova; Lubica Muckova; Lukas Prchal; Jan Korabecny; Tomas Rozsypal; Lukas Gorecki; Jakub Fibigar; Ondrej Soukup; Kamil Musilek; Daniel Jun
err分享
err收藏
Scaffold Hopping in Tuberculosis Drug Discovery: Principles; Applications; and Case Studies结核病药物发现中的骨架跃迁：原理、应用及案例研究
errJournal of Medicinal Chemistry
IF6.8
err2025-10-07
err0
errOAAI
errOndrej Kovar; Martin Kufa; Vladimir Finger; Ondrej Soukup; Martin Kratky; Carilyn Torruellas; Jaroslav Roh; Jan Korabecny
err分享
err收藏
Novel antitubercular agents based on 2,4-disubstituted 5-(aryl-2-ylmethyl)-5H-pyrrolo[3,2-d]pyrimidines基于2,4-二取代-5-(芳基-2-基甲基)-5H-吡咯并[3,2-d]嘧啶的新型抗结核药物
errBiomedicine & Pharmacotherapy
IF7.5
err2025-09-12
err0
PREAI
errVladimir Finger; Martin Vrbicky; Lubica Muckova; Lukas Prchal; Martin Novak; Jan Marek; Ondrej Soukup; Michaela Hympanova; Ales Sorf; Marketa Benkova; Jan Bartacek; Pavel Drabina; Martin Kufa; Ondrej Kovar; Lenka Fikejzlová; Martin Hruby; Oksana Ozhelevska; Johannes Jagob; Jana Zdarova-Karasova; Jitka Odvarkova; Iveta Kaderavková; Tomas Rozsypal; Katarzyna Ewa Greber; Krzesimir Ciura; Jiri Janousek; Martin Kratky; Ivone C. Igreja Sa; Pavel Bostik; Radek Sleha; Jaroslav Roh; Jan Korabecny
err分享
err收藏
Glutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation during tularemia谷氨酸利用驱动树突状细胞中快速产生线粒体ROS，并在土拉热期间引发全身性炎症。
errScience Advances
IF12.5
err2025-08-29
err0
errOAAI
errIvo Fabrik; Petra Spidlova; Lukas Prchal; Daniela Fabrikova; Ina Viduka; Valentina Marecic; Vlada Filimonenko; Radek Sleha; Marie Vajrychova; Rudolf Kupcik; Ondrej Soukup; Tomas Rousar; Anetta Härtlova; Marina Santic; Jiri Stulik
err分享
err收藏
Nanodiamond Mediated Delivery of Pyridinium Oxime Antidotes to Central Nervous System for Potential Treatment of Exposure to Nerve Agents纳米金刚石介导的吡啶氧肟酸类解毒剂向中枢神经系统的递送，用于潜在治疗神经毒剂暴露。
errChemico-Biological Interactions
IF5.4
err2025-08-16
err0
PREAI
errDenys Bondar; Olga Smirnova; Nandish M. Nagappa; Ivo Heinmaa; Ondrej Soukup; Tereza Kobrlova; Jakub Opravil; Martina Hrabinova; Daniel Jun; Pavel Starkov; Pirjo Spuul; Kamil Kuča; Vadym N. Mochalin; Yevgen Karpichev
err分享
err收藏
ADMET parameters of tacrine and its metabolites confirm unsuitability of Sus scrofa f. domestica model to study tacrine-associated hepatotoxicity他克林及其代谢物的ADMET参数证实，猪属家猪亚种模型不适合用于研究他克林相关的肝毒性。
errCHEMICO-BIOLOGICAL INTERACTIONS
IF5.4
err2025-05-27
err0
PREAI
errNovak, M.; Bures, J.; Radochova, V.; Pejchal, J.; Prchal, L.; Soukup, O.
err分享
err收藏
Revolutionizing tuberculosis treatment: Breakthroughs, challenges, and hope on the horizon革新结核病治疗：突破、挑战与未来的希望
errACTA PHARMACEUTICA SINICA B
IF14.6
err2025-01-01
err1
errOAAI
errKufa, M; Finger, V; Kovar, O; Soukup, O; Torruellas, C; Roh, J; Korabecny, J
err分享
err收藏
Automated multiple sclerosis progression rate computation of a patient from 2D FLAIR images with Rayleigh-Weibull-Fuzzy imaging and augmented morphing method
errKNOWLEDGE-BASED SYSTEMS
IF7.6
err2024-12-01
err0
PREAI
errAlpar, Orcan; Soukup, Ondrej; Ryska, Pavel; Paluska, Petr; Valis, Martin; Krejcar, Ondrej
err分享
err收藏
Dizocilpine derivatives as neuroprotective NMDA receptor antagonists without psychomimetic side effects
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
errOAAI
errKonecny, Jan; Misiachna, Anna; Chvojkova, Marketa; Kleteckova, Lenka; Kolcheva, Marharyta; Novak, Martin; Prchal, Lukas; Ladislav, Marek; Hemelikova, Katarina; Netolicky, Jakub; Hrabinova, Martina; Kobrlova, Tereza; Karasova, Jana Zdarova; Pejchal, Jaroslav; Fibigar, Jakub; Vecera, Zbynek; Kucera, Tomas; Jendelova, Pavla; Zahumenska, Petra; Langore, Emily; Doderovic, Jovana; Pang, Yuan-Ping; Vales, Karel; Korabecny, Jan; Soukup, Ondrej; Horak, Martin
err分享
err收藏
pH-induced morphological reversible transition from microparticles to vesicles for effective bacteria entrapment
errEUROPEAN POLYMER JOURNAL
IF6.3
err2024-12-01
err0
errOAAI
errSincari, Vladimir; Petrova, Svetlana Lukas; Jager, Eliezer; Jager, Alessandro; Konefal, Rafal; Gajdosova, Veronika; Slouf, Miroslav; Michaela, Hympanova; Marek, Jan; Soukup, Ondrej; Hruby, Martin
err分享
err收藏
The Effect of Tacrine on Functional Response of the Lower Oesophageal Sphincter Assessed by Endoscopic Luminal Impedance Planimetry in Experimental Pigs
errPHARMACEUTICALS
IF4.8
err2024-11-25
err0
errOAAI
errBures, Jan; Novak, Martin; Radochova, Vera; Kohoutova, Darina; Prchal, Lukas; Martinek, Jan; Mares, Jan; Cerny, Jaroslav; Suchanek, Stepan; Pejchal, Jaroslav; Voxova, Barbora; Urbanek, Petr; Zavoral, Miroslav; Soukup, Ondrej
err分享
err收藏
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2024-11-22
err0
errOAAI
errPanek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamsikova, Marie; Zemanova, Lucie; Muckova, Lubica; Vanova, Nela; Dryja, Pola; Salat, Kinga; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara
err分享
err收藏
Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-09-01
err1
errOAAI
errMisiachna, Anna; Konecny, Jan; Kolcheva, Marharyta; Ladislav, Marek; Prchal, Lukas; Netolicky, Jakub; Kortus, Stepan; Zahumenska, Petra; Langore, Emily; Novak, Martin; Hemelikova, Katarina; Hermanova, Zuzana; Hrochova, Michaela; Pelikanova, Anezka; Odvarkova, Jitka; Pejchal, Jaroslav; Kassa, Jiri; Karasova, Jana Zdarova; Korabecny, Jan; Soukup, Ondrej; Horak, Martin
err分享
err收藏
Pro-cognitive effects of dual tacrine derivatives acting as cholinesterase inhibitors and NMDA receptor antagonists
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-07-01
err2
errOAAI
errChvojkova, Marketa; Kolar, David; Kovacova, Katarina; Cejkova, Lada; Misiachna, Anna; Hakenova, Kristina; Gorecki, Lukas; Horak, Martin; Korabecny, Jan; Soukup, Ondrej; Vales, Karel
err分享
err收藏
Improved electro-destruction of bacterial biofilms by coating conductive surfaces with polymers通过用聚合物涂覆导电表面来改善细菌生物膜的电破坏
errEUROPEAN POLYMER JOURNAL
IF6.3
err2024-04-01
err1
errOAAI
errHoang, Stephane; Zhukouskaya, Hanna; Ivanko, Iryna; Svoboda, Jan; Hympanova, Michaela; Marek, Jan; Soukup, Ondrej; Slouf, Miroslav; Kotek, Jan; Doris, Eric; Gravel, Edmond; Tomsik, Elena; Hruby, Martin
err分享
err收藏
Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-04-01
err5
errOAAI
errMezeiova, Eva; Prchal, Lukas; Hrabinova, Martina; Muckova, Lubica; Pulkrabkova, Lenka; Soukup, Ondrej; Misiachna, Anna; Janousek, Jiri; Fibigar, Jakub; Kucera, Tomas; Horak, Martin; Makhaeva, Galina F.; Korabecny, Jan
err分享
err收藏
A-series agent A-234: initial in vitro and in vivo characterization
errARCHIVES OF TOXICOLOGY
IF6.9
err2024-03-06
err7
errOAAI
errHrabinova, Martina; Pejchal, Jaroslav; Hepnarova, Vendula; Muckova, Lubica; Junova, Lucie; Opravil, Jakub; Zdarova Karasova, Jana; Rozsypal, Tomas; Dlabkova, Alzbeta; Rehulkova, Helena; Kucera, Tomas; Vecera, Zbynek; Caisberger, Filip; Schmidt, Monika; Soukup, Ondrej; Jun, Daniel
err分享
err收藏
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition苯氧他克林衍生物: 低毒性神经保护剂，对ifenprodil结合位点和胆碱酯酶抑制具有亲和力
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-02-01
err8
errOAAI
errMisiachna, Anna; Svobodova, Barbora; Netolicky, Jakub; Chvojkova, Marketa; Kleteckova, Lenka; Prchal, Lukas; Novak, Martin; Hrabinova, Martina; Kucera, Tomas; Muckova, Lubica; Moravcova, Zuzana; Karasova, Jana Zdarova; Pejchal, Jaroslav; Blazek, Filip; Malinak, David; Hakenova, Kristina; Krausova, Barbora Hrcka; Kolcheva, Marharyta; Ladislav, Marek; Korabecny, Jan; Pahnke, Jens; Vales, Karel; Horak, Martin; Soukup, Ondrej
err分享
err收藏
Nakagami imaging and morphing for multiple sclerosis lesion volume estimation
errEXPERT SYSTEMS WITH APPLICATIONS
IF7.5
err2024-01-01
err3
PREAI
errAlpar, Orcan; Soukup, Ondrej; Ryska, Pavel; Dvorakova, Radka; Jandura, Jiri; Valis, Martin; Krejcar, Ondrej
err分享
err收藏

研究方向

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合作期刊
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