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Shilpi Singh

University of Minnesota
H指数:21
被引数:2,236

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Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance

前馈miR-181d降解调控甲基鸟嘌呤甲基转移酶群体方差及替莫唑胺耐药性

2025-11-100
OAAI
Variance in Methyl-guanine methyl transferase (MGMT) expression as a defining feature of intra-tumoral heterogeneity that contribute to acquired temozolomide resistance in glioblastoma

MGMT(甲基鸟嘌呤甲基转移酶)表达变异作为肿瘤内异质性的界定特征,其对胶质母细胞瘤获得性替莫唑胺耐药性的贡献。

2025-11-010
OAAI
miR-181d as a master-regulatory microRNA in glioblastomas that regulates RAD51 and MGMT expression to mediate acquired temozolomide resistance and cross-resistance to ionizing radiation

miR-181d作为胶质母细胞瘤中的主调控microRNA,通过调控RAD51和MGMT的表达来介导获得性替莫唑胺耐药以及对电离辐射的交叉耐药。

2025-11-010
OAAI