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Cell type-selective targeted delivery of a recombinant lysosomal enzyme for enzyme therapies Baik, Andrew D.; Calafati, Philip; Zhang, Xiaoli; Aaron, Nina A.; Mehra, Antonia; Moller-Tank, Sven; Miloscio, Lawrence; Praggastis, Maria; Giovannone, Nicholas; Pan, Cheryl; Tang, Yajun; Bridges, Susannah; Mujica, Alejo; Barbounis, Peter; Yanolatos, Jean; Gale, Nicholas; Li, Ning; Kyratsous, Christos A.; Schoenherr, Christopher J.; Murphy, Andrew J.; Economides, Aris N.; Cygnar, Katherine D. 分享 收藏
NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity Nistala, Harikiran; Dronzek, John; Gonzaga-Jauregui, Claudia; Chim, Shek Man; Rajamani, Saathyaki; Nuwayhid, Samer; Delgado, Dennis; Burke, Elizabeth; Karaca, Ender; Franklin, Matthew C.; Sarangapani, Prasad; Podgorski, Michael; Tang, Yajun; Dominguez, Melissa G.; Withers, Marjorie; Deckelbaum, Ron A.; Scheonherr, Christopher J.; Gahl, William A.; Malicdan, May C.; Zambrowicz, Brian; Gale, Nicholas W.; Gibbs, Richard A.; Chung, Wendy K.; Lupski, James R.; Economides, Aris N. 分享 收藏
The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells 钾通道Kcne3是血管内皮尖端细胞选择性表达的VEGFA诱导基因 Deckelbaum, Ron A.; Lobov, Ivan B.; Cheung, Eunice; Halasz, Gabor; Rajamani, Saathyaki; Lerner, Julia; Tong, Chunxiang; Li, Zhe; Boland, Patricia; Dominguez, Melissa; Hughes, Virginia; Yancopoulos, George D.; Murphy, Andrew J.; Thurston, Gavin; Cao, Jingtai; Romano, Carmelo; Gale, Nicholas W. 分享 收藏
Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct Voronina, Vera A.; Harris, Faith M.; Schmahl, Jennifer; Galligan, Caryn; Oristian, Daniel; Zamfirova, Ralica; Gong, Guochun; Bai, Yu; Fury, Wen; Rajamani, Saathyaki; Walls, Johnathon R.; Poueymirou, William T.; Esau, Lakeisha; Gale, Nicholas W.; Auerbach, Wojtek; Murphy, Andrew J.; Macdonald, Lynn E. 分享 收藏
Dendritic cells enter lymph vessels by hyaluronan-mediated docking to the endothelial receptor LYVE-1 Johnson, Louise A.; Banerji, Suneale; Lawrance, William; Gileadi, Uzi; Prota, Gennaro; Holder, Kayla A.; Roshorm, Yaowaluck M.; Hanke, Tomas; Cerundolo, Vincenzo; Gale, Nicholas W.; Jackson, David G. 分享 收藏
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Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice Mastaitis, Jason; Eckersdorff, Mark; Min, Soo; Xin, Yurong; Cavino, Katie; Aglione, Johnpaul; Okamoto, Haruka; Na, Erqian; Stitt, Trevor; Dominguez, Melissa G.; Schmahl, Jennifer P.; Lin, Calvin; Gale, Nicholas W.; Valenzuela, David M.; Murphy, Andrew J.; Yancopoulos, George D.; Gromada, Jesper 分享 收藏
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice GPR17基因破坏不会改变小鼠的食物摄入或葡萄糖稳态 Mastaitis, Jason; Min, Soo; Elvert, Ralf; Kannt, Aimo; Xin, Yurong; Ochoa, Francisca; Gale, Nicholas W.; Valenzuela, David M.; Murphy, Andrew J.; Yancopoulos, George D.; Gromada, Jesper 分享 收藏
A lymphatic defect causes ocular hypertension and glaucoma in mice Thomson, Benjamin R.; Heinen, Stefan; Jeansson, Marie; Ghosh, Asish K.; Fatima, Anees; Sung, Hoon-Ki; Onay, Tuncer; Chen, Hui; Yamaguchi, Shinji; Economides, Aris N.; Flenniken, Ann; Gale, Nicholas W.; Hong, Young-Kwon; Fawzi, Amani; Liu, Xiaorong; Kume, Tsutomu; Quaggin, Susan E. 分享 收藏
Conditionals by inversion provide a universal method for the generation of conditional alleles Economides, Aris N.; Frendewey, David; Yang, Peter; Dominguez, Melissa G.; Dore, Anthony T.; Lobov, Ivan B.; Persaud, Trikaldarshi; Rojas, Jose; McClain, Joyce; Lengyel, Peter; Droguett, Gustavo; Chernomorsky, Rostislav; Stevens, Sean; Auerbach, Wojtek; DeChiara, Thomas M.; Pouyemirou, William; Cruz, Joseph M., Jr.; Feeley, Kieran; Mellis, Ian A.; Yasenchack, Jason; Hatsell, Sarah J.; Xie, LiQin; Latres, Esther; Huang, Lily; Zhang, Yuhong; Pefanis, Evangelos; Skokos, Dimitris; Deckelbaum, Ron A.; Croll, Susan D.; Davis, Samuel; Valenzuela, David M.; Gale, Nicholas W.; Murphy, Andrew J.; Yancopoulos, George D. 分享 收藏
'In parallel' interconnectivity of the dorsal longitudinal anastomotic vessels requires both VEGF signaling and circulatory flow Zygmunt, Tomasz; Trzaska, Sean; Edelstein, Laura; Walls, Johnathon; Rajamani, Saathyaki; Gale, Nicholas; Daroles, Laura; Ramirez, Craig; Ulrich, Florian; Torres-Vazquez, Jesus 分享 收藏
Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor Anderson, Keith D.; Pan, Li; Yang, Xiao-man; Hughes, Virginia C.; Walls, Johnathon R.; Dominguez, Melissa G.; Simmons, Mary V.; Burfeind, Patricia; Xue, Yingzi; Wei, Yi; Macdonald, Lynn E.; Thurston, Gavin; Daly, Christopher; Lin, Hsin Chieh; Economides, Aris N.; Valenzuela, David M.; Murphy, Andrew J.; Yancopoulos, George D.; Gale, Nicholas W. 分享 收藏
Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice Shmelkov, Sergey V.; Hormigo, Adilia; Jing, Deqiang; Proenca, Catia C.; Bath, Kevin G.; Milde, Till; Shmelkov, Evgeny; Kushner, Jared S.; Baljevic, Muhamed; Dincheva, Iva; Murphy, Andrew J.; Valenzuela, David M.; Gale, Nicholas W.; Yancopoulos, George D.; Ninan, Ipe; Lee, Francis S.; Rafii, Shahin 分享 收藏
Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis Li, Zhe; Huang, Hui; Boland, Patricia; Dominguez, Melissa G.; Burfeind, Patricia; Lai, Ka-Man; Lin, Hsin-Chieh; Gale, Nicholas W.; Daly, Christopher; Auerbach, Wojtek; Valenzuela, David; Yancopoulos, George D.; Thurston, Gavin 分享 收藏
Angiomodulin Is a Specific Marker of Vasculature and Regulates Vascular Endothelial Growth Factor-A-Dependent Neoangiogenesis Hooper, Andrea T.; Shmelkov, Sergey V.; Gupta, Sunny; Milde, Till; Bambino, Kathryn; Gillen, Kelly; Goetz, Mollie; Chavala, Sai; Baljevic, Muhamed; Murphy, Andrew J.; Valenzuela, David M.; Gale, Nicholas W.; Thurston, Gavin; Yancopoulos, George D.; Vahdat, Linda; Evans, Todd; Rafii, Shahin 分享 收藏
Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-intrinsic Mechanisms Notch1的缺失通过细胞外在和细胞内在机制将pro-t细胞转化为树突状细胞并促进胸腺b细胞 Feyerabend, Thorsten B.; Terszowski, Grzegorz; Tietz, Annette; Blum, Carmen; Luche, Herve; Gossler, Achim; Gale, Nicholas W.; Radtke, Freddy; Fehling, Hans Joerg; Rodewald, Hans-Reimer 分享 收藏
CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors Shmelkov, Sergey V.; Butler, Jason M.; Hooper, Andrea T.; Hormigo, Adilia; Kushner, Jared; Milde, Till; St. Clair, Ryan; Baljevic, Muhamed; White, Ian; Jin, David K.; Chadburn, Amy; Murphy, Andrew J.; Valenzuela, David M.; Gale, Nicholas W.; Thurston, Gavin; Yancopoulos, George D.; D'Angelica, Michael; Kemeny, Nancy; Lyden, David; Rafii, Shahin 分享 收藏
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis Dominguez, Melissa G.; Hughes, Virginia C.; Pan, Li; Simmons, Mary; Daly, Christopher; Anderson, Keith; Noguera-Troise, Irene; Murphy, Andrew J.; Valenzuela, David M.; Davis, Samuel; Thurston, Gavin; Yancopoulos, George D.; Gale, Nicholas W. 分享 收藏
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