未登录 Exploration of Antiplasmodium Chemical Space Identifies New Inhibitors of β-Hematin Formation from Areas of Enrichment 抗疟原虫化学空间的探索从富集区域中识别出新的β-血晶素形成抑制剂 Thibaud, Jessica L.; Myburgh, Dirkie C.; Sandlin, Rebecca D.; Fong, Kim Y.; Garnie, Larnelle F.; Wicht, Kathryn J.; Kuter, David; Wright, David W.; Egan, Timothy J.; De Villiers, Katherine A. 分享 收藏
Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity Ishmail, Fatima-Zahra; Coertzen, Dina; Tshabalala, Sizwe; Leshabane, Meta; da Rocha, Shante; Njoroge, Mathew; Gibhard, Liezl; Birkholtz, Lyn-Marie; Woodland, John G.; Egan, Timothy J.; Wicht, Kathryn J.; Chibale, Kelly 分享 收藏
Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides Redway, Alexa; Spry, Christina; Brown, Ainka; Wiedemann, Ursula; Fathoni, Imam; Garnie, Larnelle F.; Qiu, Deyun; Egan, Timothy J.; Lehane, Adele M.; Jackson, Yvette; Saliba, Kevin J.; Downer-Riley, Nadale 分享 收藏
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Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates Uddin, Amad; Gupta, Sonal; Shoaib, Rumaisha; Aneja, Babita; Irfan, Iram; Gupta, Kanika; Rawat, Neha; Combrinck, Jill; Kumar, Bhumika; Aleem, Mohd; Hasan, Phool; Joshi, Mukesh C.; Chhonker, Yashpal S.; Zahid, Muhammad; Hussain, Afzal; Pandey, Kailash; Alajmi, Mohamed F.; Murry, Daryl J.; Egan, Timothy J.; Singh, Shailja; Abid, Mohammad 分享 收藏
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Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated Maaske, Jill; Sproule, Stephanie; Falsey, Ann R.; Sobieszczyk, Magdalena E.; Luetkemeyer, Anne F.; Paulsen, Grant C.; Riddler, Sharon A.; Robb, Merlin L.; Rolle, Charlotte-Paige; Sha, Beverly E.; Tong, Tina; Ahani, Bahar; Aksyuk, Anastasia A.; Bansal, Himanshu; Egan, Timothy; Jepson, Brett; Padilla, Marcelino; Patel, Nirmeshkumar; Shoemaker, Kathryn; Stanley, Ann Marie; Swanson II, Phillip A.; Wilkins, Deidre; Villafana, Tonya; Green, Justin A.; Kelly, Elizabeth J. 分享 收藏
Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model Mambwe, Dickson; Korkor, Constance M.; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J.; Chibale, Kelly 分享 收藏
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Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model (vol 63, pg 13013, 2020) Horatscheck, Andre; Andrijevic, Ana; Nchinda, Aloysius T.; Le Manach, Claire; Paquet, Tanya; Khonde, Lutete Peguy; Dam, Jean; Pawar, Kailash; Taylor, Dale; Lawrence, Nina; Brunschwig, Christel; Gibhard, Liezl; Njoroge, Mathew; Reader, Janette; van der Watt, Mariette; Wicht, Kathryn; de Sousa, Ana Carolina C.; Okombo, John; Maepa, Keletso; Egan, Timothy J.; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Wittlin, Sergio; Fish, Paul V.; Street, Leslie J.; Duffy, James; Chibale, Kelly 分享 收藏
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Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model Horatscheck, Andre; Andrijevic, Ana; Nchinda, Aloysius T.; Le Manach, Claire; Paquet, Tanya; Khonde, Lutete Peguy; Dam, Jean; Pawar, Kailash; Taylor, Dale; Lawrence, Nina; Brunschwig, Christel; Gibhard, Liezl; Njoroge, Mathew; Reader, Janette; van der Watt, Mariette; Wicht, Kathryn; de Sousa, Ana Carolina C.; Okombo, John; Maepa, Keletso; Egan, Timothy J.; Birkholtz, Lyn-Marie; Basarab, Gregory S.; Wittlin, Sergio; Fish, Paul, V; Street, Leslie J.; Duffy, James; Chibale, Kelly 分享 收藏
Preclinical development and mechanism of action studies of NM21-1480, a PD-L1/4-1BB/HSA trispecific MATCH3 therapeutic clinical candidate PD-L1/4-1BB/HSA三特异性MATCH3治疗临床候选药物NM21-1480的临床前开发和作用机制研究 Snell, Daniel; Gunde, Tea; Warmuth, Stefan; Lichtlen, Peter; Tietz, Julia; Brock, Matthias; Simonin, Alexandre; Hess, Christian; Christopher, Weinert; Heiz, Robin; Flueckiger, Naomi; Zeberer, Julia; Diem, Dania; Mahler, Dana; Morenzoni, Diego; Wickihalder, Belinda; Muntwiler, Simone; Poelderl, Antonia; Kuettner, Benjamin; Wagen, Sandro; Meyer, Sebastian; Egan, Timothy; Urech, David 分享 收藏
Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products Moyo, Phanankosi; Shamburger, William; van der Watt, Mariette E.; Reader, Janette; de Sousa, Ana Carolina C.; Egan, Timothy J.; Maharaj, Vinesh J.; Bringmann, Gerhard; Birkholtz, Lyn-Marie 分享 收藏
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway 泛活性咪唑哌嗪抗疟药靶向恶性疟原虫细胞内分泌途径 LaMonte, Gregory M.; Rocamora, Frances; Marapana, Danushka S.; Gnadig, Nina F.; Ottilie, Sabine; Luth, Madeline R.; Worgall, Tilla S.; Goldgof, Gregory M.; Mohunlal, Roxanne; Kumar, T. R. Santha; Thompson, Jennifer K.; Vigil, Edgar; Yang, Jennifer; Hutson, Dylan; Johnson, Trevor; Huang, Jianbo; Williams, Roy M.; Zou, Bing Yu; Cheung, Andrea L.; Kumar, Prianka; Egan, Timothy J.; Lee, Marcus C. S.; Siegel, Dionicio; Cowman, Alan F.; Fidock, David A.; Winzeler, Elizabeth A. 分享 收藏
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Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2-a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria Mayoka, Godfrey; Njoroge, Mathew; Okombo, John; Gibhard, Liezl; Sanches-Vaz, Margarida; Fontinha, Diana; Birkholtz, Lyn-Marie; Reader, Janette; van der Watt, Mariette; Coetzer, Theresa L.; Lauterbach, Sonja; Churchyard, Alisje; Bezuidenhout, Belinda; Egan, Timothy J.; Yeates, Clive; Wittlin, Sergio; Prudencio, Miguel; Chibale, Kelly 分享 收藏
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