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Alan F. Cowman

Merck & Co., Inc.

113H指数
462论文数
4.2W被引数
收录论文 160
发表时间
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2-Amino-3; 4-Dihydroquinazolines Exhibit Potent Antimalarial Activity by Targeting Plasmepsin X2-氨基-3,4-二氢喹唑啉类化合物通过靶向血红素X展示显著的抗疟疾活性
errACS Infectious Diseases
IF3.8
err2026-08-14
err0
PREAI
errMadeline G. Dans; Jon Kyle Awalt; Nghi Nguyen; Josephine Palandri; Anna Ngo; Kate E. Jarman; Jin H. Jeon; Tomas Yeo; Heekuk Park; Anne-Catrin Uhlemann; Emma Y. Mao; Maria R. Gancheva; Danny W. Wilson; Partha Mukherjee; Arnish Chakraborty; Mojca Kristan; Lindsay Stewart; Colin J. Sutherland; Delphine Baud; Stephen Brand; David A. Fidock; Paul F. Jackson; Alan F. Cowman; Brad E. Sleebs
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GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparumGID/CTLH E3连接酶复合物控制恶性疟原虫性发育的细胞命运程序
errNature Communications
IF15.7
err2026-04-15
err0
errOAAI
errDanushka S. Marapana; Sash Lopaticki; Balu Balan; Kitsanapong Reaksudsan; Simon A. Cobbold; Niall D. Geoghegan; Sachin Khurana; Stephen W. Scally; Peter Hickey; Niva Jayakrishnan; Vineet Vaibhav; Sukhdeep Spall; Jumana M. Yousef; Laura F. Dagley; Christopher D. Goodman; Anton Cozijnsen; Geoffrey I. McFadden; Kelly L. Rogers; Aaron Jex; David Komander; James S. McCarthy; Christopher J. Tonkin; Matthew W. A. Dixon; Alan F. Cowman
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PTRAMP, CSS and Ripr form a conserved complex required for merozoite invasion of Plasmodium species into erythrocytesPTRAMP，CSS和Ripr形成裂殖子侵入疟原虫物种进入红细胞所需的保守复合物
errNature Communications
IF15.7
err2026-01-26
err0
errOAAI
errBenjamin A. Seager; Pailene S. Lim; Xiao Xiao; Keng Heng Lai; Lionel Brice Feufack-Donfack; Sheena Dass; Nicolai C. Jung; Anju Abraham; Matthew J. Grigg; Nicholas M. Anstey; Timothy William; Jetsumon Sattabongkot; Andrew Leis; Rhea J. Longley; Manoj T. Duraisingh; Jean Popovici; Danny W. Wilson; Alan F. Cowman; Stephen W. Scally
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err收藏
CD44 cross-linking promotes Plasmodium falciparum invasionCD44交联促进恶性疟原虫入侵
errNature Communications
IF15.7
err2025-12-07
err0
errOAAI
errAngel K. Kongsomboonvech; Stephen W. Scally; Yann Le Guen; Praveesh Valissery; Nichole D. Salinas; Alan F. Cowman; Niraj H. Tolia; Elizabeth S. Egan
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Exploration and Characterization of the Antimalarial Activity of Pyrimidine-2,4-Diamines for which Resistance is Mediated by the ABCI3 Transporter针对由ABCI3转运蛋白介导耐药性的嘧啶-2,4-二胺类化合物的抗疟活性探索与表征
errCHEMMEDCHEM
IF3.4
err2025-12-01
err0
errOAAI
errMansouri, Mahta; Dans, Madeline G.; Low, Zijun; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Lehane, Adele M.; Crespo, Benigno; Gamo, Franciso-javier; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
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Deconvolution of the On-Target Activity of Plasmepsin V Peptidomimetics in Plasmodium falciparum Parasites在恶性疟原虫中解卷积靶向活性的质膜素V类肽模拟物
errACS INFECTIOUS DISEASES
IF3.8
err2025-12-01
err0
PREAI
errSu, Wenyin; Nguyen, William; Siddiqui, Ghizal; Dziekan, Jerzy M.; Marapana, Danushka; Penington, Jocelyn Sietsma; Mehra, Somya; Razook, Zahra; McCann, Kirsty; Ngo, Anna; Jarman, Kate E.; Barry, Alyssa E.; Papenfuss, Anthony T.; Gilson, Paul R.; Creek, Darren John; Cowman, Alan F.; Sleebs, Brad E.; Dans, Madeline G.
err分享
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Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug原生疟疾翻译机器的结构生物学集成及其被抗疟药物抑制的研究
errNature Structural & Molecular Biology
IF10.1
err2025-08-18
err0
errOAAI
errLeonie Anton; Wenjing Cheng; Meseret T. Haile; Jerzy M. Dziekan; David W. Cobb; Xiyan Zhu; Leyan Han; Emerson Li; Anjali Nair; Carolyn L. Lee; Hanyu Wang; Hangjun Ke; Guoan Zhang; Emma H. Doud; Alan F. Cowman; Chi-Min Ho
err分享
err收藏
Optimization and Characterization of N-Acetamide Indoles as Antimalarials That Target PfATP4N-乙酰胺基吲哚类化合物的优化与表征：靶向PfATP4的抗疟疾药物研究
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-04-14
err0
PREAI
errAwalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
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Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors亚氨基嘧啶酮稠合的吡咯烷的结构活性分析有助于双重plasmepsin V和plasmepsin X抑制剂的开发
errFEBS JOURNAL
IF4.2
err2025-03-01
err0
errOAAI
errHodder, Anthony N.; Sleebs, Brad E.; Adams, Greg; Rezazadeh, Sina; Ngo, Anna; Jarman, Kate; Scally, Stephen; Czabotar, Peter; Wang, Hongwu; Mccauley, John A.; Olsen, David B.; Cowman, Alan F.
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Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-12-01
err0
errOAAI
errAwalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.
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Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4内酰胺截短产生具有针对PfATP4的有效抗疟活性的二氢喹唑啉酮支架
errCHEMMEDCHEM
IF3.4
err2024-10-29
err1
PREAI
errAshton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Loi, Katie; Jarman, Kate E.; Palandri, Josephine; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash; De, Nirupam; Famodimu, Mufuliat T.; Delves, Michael J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
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Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3具有有效抗疟活性的吡唑并吡啶4-甲酰胺的优化，其抗性与恶性疟原虫转运蛋白ABCI3相关
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-10-01
err3
errOAAI
errCalic, Petar P. S.; Ashton, Trent D.; Mansouri, Mahta; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Roy, Sayantan; Rao, Gunturu P.; Maity, Bikash; Wittlin, Sergio; Crespo, Benigno; Gamo, Franciso-Javier; Deni, Ioanna; Fidock, David A.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Cowman, Alan F.; Jackson, Paul F.; Baud, Delphine; Brand, Stephen; Laleu, Benoit; Sleebs, Brad E.
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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 (vol 15, 5219, 2024)芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1 (vol 15，5219，2024) 防止恶性疟原虫环发育
errNATURE COMMUNICATIONS
IF15.7
err2024-09-30
err0
errOAAI
errDans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4Dihydroquinazolinone-3-carboxamides作为靶向PfATP4的口服有效抗疟药的性质和活性精制
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-08-12
err2
errOAAI
errAshton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Palandri, Josephine; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash Chandra; De, Nirupam; Giannangelo, Carlo; Macraild, Christopher A.; Creek, Darren J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Famodimu, Mufuliat T.; Delves, Michael J.; Pollard, Harry; Sutherland, Colin J.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.
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Flp/ FRT- mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver- stage development恶性疟原虫子孢子中Flp/ FRT介导的ptex150和exp2的破坏抑制了肝脏阶段的发育
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-07-05
err1
errOAAI
errMcConville, Robyn; Krol, Jelte M. M.; Steel, Ryan W. J.; O'Neill, Matthew T.; Davey, Bethany K.; Hodder, Anthony N.; Nebl, Thomas; Cowman, Alan F.; Kneteman, Norman; Boddey, Justin A.
err分享
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Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1阻止恶性疟原虫环的发展
errNATURE COMMUNICATIONS
IF15.7
err2024-06-18
err5
errOAAI
errDans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.
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Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein靶向恶性疟原虫星形相关脂质转移1蛋白的芳基氨基乙酰胺的活性精制
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-04-01
err4
errOAAI
errNguyen, William; Boulet, Coralie; Dans, Madeline G.; Loi, Katie; Jarman, Kate E.; Watson, Gabrielle M.; Tham, Wai-Hong; Fairhurst, Kate J.; Yeo, Tomas; Fidock, David A.; Wittlin, Sergio; Chowdury, Mrittika; de Koning-Ward, Tania F.; Chen, Gong; Yan, Dandan; Charman, Susan A.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Gilson, Paul R.; Sleebs, Brad E.
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Chemo-proteomics in antimalarial target identification and engagement化学-蛋白质组学在抗疟靶点识别和参与中的应用
errMEDICINAL RESEARCH REVIEWS
IF11.6
err2023-05-26
err8
errOAAI
errBailey, Brodie L. L.; Nguyen, William; Cowman, Alan F. F.; Sleebs, Brad E. E.
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Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasionPlasmepsin X通过处理PfRh5以入侵红细胞来激活恶性疟原虫的PCRCR复合物
errNATURE COMMUNICATIONS
IF15.7
err2023-04-19
err7
errOAAI
errTriglia, Tony; Scally, Stephen W.; Seager, Benjamin A.; Pasternak, Michal; Dagley, Laura F.; Cowman, Alan F.
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Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes恶性疟原虫感染的红细胞的起源和贩运
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err125
errOAAI
errSpycher, Cornelia; Rug, Melanie; Klonis, Nectarios; Ferguson, David J. P.; Cowman, Alan F.; Beck, Hans-Peter; Tilley, Leann
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