Awalt, Jon Kyle; Ooi, Zi Kang; Ashton, Trent D.; Mansouri, Mahta; Calic, Petar P. S.; Zhou, Qingmiao; Vasanthan, Santhya; Lee, Serena; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Qiu, Deyun; Zhang, Xinxin; Lehane, Adele M.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Giannangelo, Carlo; MacRaild, Christopher A.; Creek, Darren J.; Yeo, Tomas; Sheth, Tanaya; Fidock, David A.; Churchyard, Alisje; Baum, Jake; Famodimu, Mufuliat T.; Delves, Michael J.; Kristan, Mojca; Stewart, Lindsay; Sutherland, Colin J.; Coyle, Rachael; Jagoe, Hannah; Lee, Marcus C. S.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.

Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

亚氨基嘧啶酮稠合的吡咯烷的结构活性分析有助于双重plasmepsin V和plasmepsin X抑制剂的开发

FEBS JOURNAL

IF4.2

2025-03-010

OAAI

Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b

针对线粒体蛋白，细胞色素b的环丙基甲酰胺的抗疟活性的探索和表征

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-12-010

OAAI

Awalt, Jon Kyle; Su, Wenyin; Nguyen, William; Loi, Katie; Jarman, Kate E.; Penington, Jocelyn S.; Ramesh, Saishyam; Fairhurst, Kate J.; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Maity, Bikash Chandra; De, Nirupam; Mukherjee, Partha; Chakraborty, Arnish; Churchyard, Alisje; Famodimu, Mufuliat T.; Delves, Michael J.; Baum, Jake; Mittal, Nimisha; Winzeler, Elizabeth A.; Papenfuss, Anthony T.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Maier, Alexander G.; van Dooren, Giel G.; Baud, Delphine; Brand, Stephen; Fidock, David A.; Jackson, Paul F.; Cowman, Alan F.; Dans, Madeline G.; Sleebs, Brad E.

Lactam Truncation Yields a Dihydroquinazolinone Scaffold with Potent Antimalarial Activity that Targets PfATP4

内酰胺截短产生具有针对PfATP4的有效抗疟活性的二氢喹唑啉酮支架

CHEMMEDCHEM

IF3.4

2024-10-291

PRE

Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the P. falciparum transporter ABCI3

具有有效抗疟活性的吡唑并吡啶4-甲酰胺的优化，其抗性与恶性疟原虫转运蛋白ABCI3相关

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-10-013

OAAI

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1 (vol 15, 5219, 2024)

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1 (vol 15，5219，2024) 防止恶性疟原虫环发育

NATURE COMMUNICATIONS

IF15.7

2024-09-300

OAAI

Dans, Madeline G.; Boulet, Coralie; Watson, Gabrielle M.; Nguyen, William; Dziekan, Jerzy M.; Evelyn, Cindy; Reaksudsan, Kitsanapong; Mehra, Somya; Razook, Zahra; Geoghegan, Niall D.; Mlodzianoski, Michael J.; Goodman, Christopher Dean; Ling, Dawson B.; Jonsdottir, Thorey K.; Tong, Joshua; Famodimu, Mufuliat Toyin; Kristan, Mojca; Pollard, Harry; Stewart, Lindsay B.; Brandner-Garrod, Luke; Sutherland, Colin J.; Delves, Michael J.; Mcfadden, Geoffrey I.; Barry, Alyssa E.; Crabb, Brendan S.; de Koning-Ward, Tania F.; Rogers, Kelly L.; Cowman, Alan F.; Tham, Wai-Hong; Sleebs, Brad E.; Gilson, Paul R.

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4

Dihydroquinazolinone-3-carboxamides作为靶向PfATP4的口服有效抗疟药的性质和活性精制

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-08-122

OAAI

Ashton, Trent D.; Calic, Petar P. S.; Dans, Madeline G.; Ooi, Zi Kang; Zhou, Qingmiao; Palandri, Josephine; Loi, Katie; Jarman, Kate E.; Qiu, Deyun; Lehane, Adele M.; Maity, Bikash Chandra; De, Nirupam; Giannangelo, Carlo; Macraild, Christopher A.; Creek, Darren J.; Mao, Emma Y.; Gancheva, Maria R.; Wilson, Danny W.; Chowdury, Mrittika; de Koning-Ward, Tania F.; Famodimu, Mufuliat T.; Delves, Michael J.; Pollard, Harry; Sutherland, Colin J.; Baud, Delphine; Brand, Stephen; Jackson, Paul F.; Cowman, Alan F.; Sleebs, Brad E.

Flp/ FRT- mediated disruption of ptex150 and exp2 in Plasmodium falciparum sporozoites inhibits liver- stage development

恶性疟原虫子孢子中Flp/ FRT介导的ptex150和exp2的破坏抑制了肝脏阶段的发育

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-07-051

OAAI

Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1

芳基氨基乙酰胺通过靶向脂质转移蛋白PfSTART1阻止恶性疟原虫环的发展

NATURE COMMUNICATIONS

IF15.7

2024-06-185

OAAI