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Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24-hydroxylase inhibitor soticlestat in healthy volunteers Yin, Wei; Ballard, T. Eric; Zhu, Sean Xiaochun; Hsiao, Samuel; Chen, Hao; Li, Yuexian; Chowdhury, Swapan K.; Stevenson, Annette; Hui, Tom; Hunt, Allen; Asgharnejad, Mahnaz; Han, Steve 分享 收藏
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Phase I study assessing the mass balance, pharmacokinetics, and excretion of [14C]-pevonedistat, a NEDD8-activating enzyme inhibitor in patients with advanced solid tumors Zhou, Xiaofei; Sedarati, Farhad; Faller, Douglas V.; Zhao, Dan; Faessel, Helene M.; Chowdhury, Swapan; Bolleddula, Jayaprakasam; Li, Yuexian; Venkatakrishnan, Karthik; Papai, Zsuzsanna 分享 收藏
Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors Zhou, Xiaofei; Pusalkar, Sandeepraj; Chowdhury, Swapan K.; Searle, Shawn; Li, Yuexian; Ullmann, Claudio Dansky; Venkatakrishnan, Karthik 分享 收藏
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A phase I study to assess the mass balance, excretion, and pharmacokinetics of [14C]-ixazomib, an oral proteasome inhibitor, in patients with advanced solid tumors Gupta, Neeraj; Zhang, Steven; Pusalkar, Sandeepraj; Plesescu, Mihaela; Chowdhury, Swapan; Hanley, Michael J.; Wang, Bingxia; Xia, Cindy; Zhang, Xiaoquan; Venkatakrishnan, Karthik; Shepard, Dale R. 分享 收藏
Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury Fasiglifam (TAK-875) 改变大鼠和狗的胆汁酸稳态: 药物引起的肝损伤的潜在原因 Wolenski, Francis S.; Zhu, Andy Z. X.; Johnson, Mike; Yu, Shaoxia; Moriya, Yuu; Ebihara, Takuya; Csizmadia, Vilmos; Grieves, Jessica; Paton, Martin; Liao, Mingxiang; Gemski, Christopher; Pan, Liping; Vakilynejad, Majid; Dragan, Yvonne P.; Chowdhury, Swapan K.; Kirby, Patrick J. 分享 收藏
A phase I dose escalation, safety and pharmacokinetic (PK) study of AZD5312 (IONIS-ARRx), a first-in-class Generation 2.5 antisense oligonucleotide targeting the androgen receptor (AR) Chowdhury, S.; Burris, H. A.; Patel, M.; Infante, J. R.; Jones, S. F.; Voskoboynik, M.; Parry, K.; Elvin, R.; Coleman, T.; Gardner, H.; Lyne, P. D.; Arkenau, H. T. 分享 收藏
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Combination schedule optimization through preclinical PK-efficacy modeling of an investigational novel-novel combination: A case study of MLN0128 an mTORC1/2 inhibitor with MLN1117 a PI3Kα isoform selective inhibitor. Zopf, Christopher; Patel, Mayank; Kadakia, Ekta; Fabry, Robyn; Chakravarty, Arijit; Chowdhury, Swapan; Wu, Jing-Tao; Shyu, Wen Chyi; Manfredi, Mark; Zohren, Fabian; Patel, Chirag; Kuida, Keisuke; Iartchouk, Natasha; Brake, Rachael; Mettetal, Jerome 分享 收藏
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