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Inhibition of histone methyltransferase EZH2 for immune-interception of colorectal cancer in Lynch syndrome Duzagac, Fahriye; Bowen, Charles M.; Reyes-Uribe, Laura; Zaheer, Mahira; Thompson, Jacklyn; Deng, Nan; Taggart, Melissa; Jain, Abhinav; Edelmann, Winfried; Sinha, Krishna M.; Vilar, Eduardo 分享 收藏
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease 针对亨廷顿氏病体细胞不稳定性的治疗剂的CAG重复阈值 Aldous, Sarah G.; Smith, Edward J.; Landles, Christian; Osborne, Georgina F.; Canibano-Pico, Maria; Nita, Iulia M.; Phillips, Jemima; Zhang, Yongwei; Jin, Bo; Hirst, Marissa B.; Benn, Caroline L.; Bond, Brian C.; Edelmann, Winfried; Greene, Jonathan R.; Bates, Gillian P. 分享 收藏
Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition Bedard, Gabriel T.; Gilaj, Nord; Peregrina, Karina; Brew, Isabella; Tosti, Elena; Shaffer, Karl; Tyler, Peter C.; Edelmann, Winfried; Augenlicht, Leonard H.; Schramm, Vern L. 分享 收藏
Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae Razani, B; Wang, XB; Engelman, JA; Battista, M; Lagaud, G; Zhang, XL; Kneitz, B; Hou, H; Christ, GJ; Edelmann, W; Lisanti, MP 分享 收藏
Blockade of the immunosuppressive KIR2DL5/PVR pathway elicits potent human NK cell-mediated antitumor immunity Ren, Xiaoxin; Peng, Mou; Xing, Peng; Wei, Yao; Galbo Jr., Phillip M.; Corrigan, Devin; Wang, Hao; Su, Yingzhen; Dong, Xiaoshen; Sun, Qizhe; Li, Yixian; Zhang, Xiaoyu; Edelmann, Winfried; Zheng, Deyou; Zang, Xingxing 分享 收藏
Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice Wang, Shanzhi; Lee, Kyeryoung; Gray, Stephen; Zhang, Yongwei; Tang, Catherine; Morrish, Rikke B.; Tosti, Elena; van Oers, Johanna; Amin, Mohammad Ruhul; Cohen, Paula E.; MacCarthy, Thomas; Roa, Sergio; Scharff, Matthew D.; Edelmann, Winfried; Chahwan, Richard 分享 收藏
Genome Replication Is Associated With Release of Immunogenic DNA Waste 基因组复制与免疫原性DNA废物的释放有关 Schubert, Nadja; Schumann, Tina; Daum, Elena; Flade, Karolin; Ge, Yan; Hagedorn, Lara; Edelmann, Winfried; Mueller, Luise; Schmitz, Marc; Kuut, Gunnar; Hornung, Veit; Behrendt, Rayk; Roers, Axel 分享 收藏
Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer Tosti, Elena; Almeida, Ana S.; Tran, Tam T. T.; Barbachan e Silva, Mariel; Broin, Pilib O.; Dubin, Robert; Chen, Ken; Beck, Amanda P.; Mclellan, Andrew S.; Vilar, Eduardo; Golden, Aaron; O'Toole, Paul W.; Edelmann, Winfried 分享 收藏
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model Gebert, Johannes; Gelincik, Ozkan; Oezcan-Wahlbrink, Mine; Marshall, Jason D.; Hernandez-Sanchez, Alejandro; Urban, Katharina; Long, Mark; Cortes, Eduardo; Tosti, Elena; Katzenmaier, Eva-Maria; Song, Yurong; Elsaadi, Ali; Deng, Nan; Vilar, Eduardo; Fuchs, Vera; Nelius, Nina; Yuan, Yan P.; Ahadova, Aysel; Sei, Shizuko; Shoemaker, Robert H.; Umar, Asad; Wei, Lei; Liu, Song; Bork, Peer; Edelmann, Winfried; Doeberitz, Magnus von Knebel; Lipkin, Steven M.; Kloor, Matthias 分享 收藏
The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells Bommi, Prashant, V; Bowen, Charles M.; Reyes-Uribe, Laura; Wu, Wenhui; Katayama, Hiroyuki; Rocha, Pedro; Parra, Edwin R.; Francisco-Cruz, Alejandro; Ozcan, Zuhal; Tosti, Elena; Willis, Jason A.; Wu, Hong; Taggart, Melissa W.; Burks, Jared K.; Lynch, Patrick M.; Edelmann, Winfried; Scheet, Paul A.; Wistuba, Ignacio I.; Sinha, Krishna M.; Hanash, Samir M.; Vilar, Eduardo 分享 收藏
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria Yasuda, Makiko; Gan, Lin; Chen, Brenden; Yu, Chunli; Zhang, Jinglan; Gama-Sosa, Miguel A.; Pollak, Daniela D.; Berger, Stefanie; Phillips, John D.; Edelmann, Winfried; Desnick, Robert J. 分享 收藏
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MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development Eso, Yuji; Takai, Atsushi; Matsumoto, Tomonori; Inuzuka, Tadashi; Horie, Takahiro; Ono, Koh; Uemoto, Shinji; Lee, Kyeryoung; Edelmann, Winfried; Chiba, Tsutomu; Marusawa, Hiroyuki 分享 收藏
A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies Zhang, Yongliang; Fox, Jennifer T.; Park, Young-Un; Elliott, Gene; Rai, Ganesha; Cai, Mengli; Sakamuru, Srilatha; Huang, Ruili; Xia, Menghang; Lee, Kyeryoung; Jeon, Min Ho; Mathew, Bijoy P.; Park, Hee Dong; Edelmann, Winfried; Park, Chan Young; Hong, Sung You; Maloney, David; Myung, Kyungjae 分享 收藏
Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation He, Shuying; Limi, Saima; McGreal, Rebecca S.; Xie, Qing; Brennan, Lisa A.; Kantorow, Wanda Lee; Kokavec, Juraj; Majumdar, Romit; Hou, Harry, Jr.; Edelmann, Winfried; Liu, Wei; Ashery-Padan, Ruth; Zavadil, Jiri; Kantorow, Marc; Skoultchi, Arthur I.; Stopka, Tomas; Cvekl, Ales 分享 收藏
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Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia Will, Britta; Vogler, Thomas O.; Narayanagari, Swathi; Bartholdy, Boris; Todorova, Tihomira I.; Ferreira, Mariana da Silva; Chen, Jiahao; Yu, Yiting; Mayer, Jillian; Barreyro, Laura; Carvajal, Luis; Ben Neriah, Daniela; Roth, Michael; van Oers, Johanna; Schaetzlein, Sonja; McMahon, Christine; Edelmann, Winfried; Verma, Amit; Steidl, Ulrich 分享 收藏
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