未登录 Bitopic inhibitors of mTORC1 cooperate with inhibitors of mitogen-activated protein kinase kinase to drive cytotoxicity in glioblastoma mTORC1双位点抑制剂与丝裂原活化蛋白激酶激酶抑制剂协同作用，以驱动胶质母细胞瘤的细胞毒性。 Fan, Qiwen; Koach, Jessica; Luo, Karen; Clark, Sydney; Reddy, Shruthi; Ozawa, Tomoko; Wang, Linyu; Yoda, Hiroyuki; Sale, Matthew; Mccormick, Frank; Raleigh, David R.; Gustafson, William C.; Meyerowitz, Justin; Singh, Mallika; Berger, Mitchel; Shokat, Kevan M.; Weiss, William A. 分享 收藏
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers 在RAS驱动的癌症中通过RMC-6236抑制RAS-GTP的翻译和治疗评估 Jiang, Jingjing; Jiang, Lingyan; Maldonato, Benjamin J.; Wang, Yingyun; Holderfield, Matthew; Aronchik, Ida; Winters, Ian P.; Salman, Zeena; Blaj, Cristina; Menard, Marie; Brodbeck, Jens; Chen, Zhe; Wei, Xing; Rosen, Michael J.; Gindin, Yevgeniy; Lee, Bianca J.; Evans, James W.; Chang, Stephanie; Wang, Zhican; Seamon, Kyle J.; Parsons, Dylan; Cregg, James; Marquez, Abby; Tomlinson, Aidan C. A.; Yano, Jason K.; Knox, John E.; Quintana, Elsa; Aguirre, Andrew J.; Arbour, Kathryn C.; Reed, Abby; Gustafson, W. Clay; Gill, Adrian L.; Koltun, Elena S.; Wildes, David; Smith, Jacqueline A. M.; Wang, Zhengping; Singh, Mallika 分享 收藏
ALK upregulates POSTN and WNT signaling to drive neuroblastoma Huang, Miller; Fang, Wanqi; Farrel, Alvin; Li, Linwei; Chronopoulos, Antonios; Nasholm, Nicole; Cheng, Bo; Zheng, Tina; Yoda, Hiroyuki; Barata, Megumi J.; Porras, Tania; Miller, Matthew L.; Zhen, Qiqi; Ghiglieri, Lisa; Mchenry, Lauren; Wang, Linyu; Asgharzadeh, Shahab; Park, Jinseok; Gustafson, W. Clay; Matthay, Katherine K.; Maris, John M.; Weiss, William A. 分享 收藏
Preliminary safety and pharmacokinetic profiles of RMC-6236, a first-in-class, RAS-selective, tri-complex RASMULTI(ON) inhibitor in patients with KRAS mutant solid tumors on the Phase 1 trial RMC-6236-001 Spira, Alexander I.; Starodub, Alexander N.; Arbour, Kathryn C.; Sommerhalder, David; Wolpin, Brian M.; Barve, Minal; Garrido-Laguna, Ignacio; Punekar, Salman; Pelster, Meredith; Kar, Sumit; Wong, Jamie; Lin, Tong; Raman, Rakesh; Tao, Lin; Salman, Zeena; Wang, Xiaolin; Gustafson, W. Clay; Hong, David S. 分享 收藏
First-in-human phase 1/1b trial of the first-in-class bi-steric mTORC1-selective inhibitor RMC-5552 in patients with advanced solid tumors Schram, Alison M.; Nagash, Abdul Rafeh; Haura, Eric B.; Riess, Jonathan W.; Ulahannan, Susanna V.; Ou, Sai-Hong I.; Capasso, Anna; Munster, Pamela N.; Cheng, Michael L.; Gustafson, W. Clay; Bitman, Bojena; Kar, Sumit; Wang, Zhican; Tao, Lin; Meyerowitz, Justin G.; Burns, Howard A. 分享 收藏
GATOR2-dependent mTORC1 activity is a therapeutic vulnerability in FOXO1 fusion-positive rhabdomyosarcoma Morales, Jacqueline; Allegakoen, David, V; Garcia, Jose A.; Kwong, Kristen; Sahu, Pushpendra K.; Fajardo, Drew A.; Pan, Yue; Horlbeck, Max A.; Weissman, Jonathan S.; Gustafson, W. Clay; Bivona, Trever G.; Sabnis, Amit J. 分享 收藏
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53 Yi, Joanna S.; Sias-Garcia, Oscar; Nasholm, Nicole; Hu, Xiaoyu; Iniguez, Amanda Balboni; Hall, Matthew D.; Davis, Mindy; Guha, Rajarshi; Moreno-Smith, Myrthala; Barbieri, Eveline; Duong, Kevin; Koach, Jessica; Qi, Jun; Bradner, James E.; Stegmaier, Kimberly; Weiss, William A.; Gustafson, W. Clay 分享 收藏
124I-MIBG PET/CT to Monitor Metastatic Disease in Children with Relapsed Neuroblastoma Aboian, Mariam S.; Huang, Shih-ying; Hernandez-Pampaloni, Miguel; Hawkins, Randall A.; VanBrocklin, Henry F.; Huh, Yoonsuk; Vo, Kieuhoa T.; Gustafson, W. Clay; Matthay, Katherine K.; Seo, Youngho 分享 收藏
Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface Koach, Jessica; Holien, Jessica K.; Massudi, Hassina; Carter, Daniel R.; Ciampa, Olivia C.; Herath, Mika; Lim, Taylor; Seneviratne, Janith A.; Milazzo, Giorgio; Murray, Jayne E.; McCarroll, Joshua A.; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W.; Gorman, Michael A.; Bell, Jessica L.; Doughty, Larissa; Huettelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J.; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W. Clay; Haber, Michelle; Norris, Murray D.; Fletcher, Jamie I.; Perini, Giovanni; Parker, Michael W.; Cheung, Belamy B.; Marshall, Glenn M. 分享 收藏
INVESTIGATING IMMUNOSUPPRESSIVE MECHANISMS IN THE TUMOR MICROENVIRONMENT OF HIGH-RISK NEUROBLASTOMA; AN IMMUNOCOMPETENT, MYCN-DRIVEN, NON-GERMLINE GEM MODEL Menard, Marie; McHenry, Lauren; Nasholm, Nicole; Wong-Michalak, Shannon; Lu, Edbert; Simonds, Erin; Gustafson, W. Clay; Weiss, William A. 分享 收藏
分享 收藏
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 Chen, Liying; Alexe, Gabriela; Dharia, Neekesh V.; Ross, Linda; Iniguez, Amanda Balboni; Conway, Amy Saur; Wang, Emily Jue; Veschi, Veronica; Lam, Norris; Qi, Jun; Gustafson, W. Clay; Nasholm, Nicole; Vazquez, Francisca; Weir, Barbara A.; Cowley, Glenn S.; Ali, Levi D.; Pantel, Sasha; Jiang, Guozhi; Harrington, William F.; Lee, Yenarae; Goodale, Amy; Lubonja, Rakela; Krill-Burger, John M.; Meyers, Robin M.; Tsherniak, Aviad; Root, David E.; Bradner, James E.; Golub, Todd R.; Roberts, Charles W. M.; Hahn, William C.; Weiss, William A.; Thiele, Carol J.; Stegmaier, Kimberly 分享 收藏
Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group (vol 43, pg 474, 2016) Temple, William; Mendelsohn, Lori; Kim, Grace E.; Nekritz, Erin; Gustafson, W. Clay; Lin, Lawrence; Giacomini, Kathy; Naranjo, Arlene; Van Ryn, Collin; Parisi, Marguerite T.; Shulkin, Barry L.; Yanik, Gregory A.; Kreissman, Susan G.; Hogarty, Michael; Matthay, Katherine K.; DuBois, Steven G. 分享 收藏
Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group Temple, William; Mendelsohn, Lori; Kim, Grace E.; Nekritz, Erin; Gustafson, W. Clay; Lin, Lawrence; Giacomini, Kathy; Naranjo, Arlene; Van Ryn, Collin; Yanik, Gregory A.; Kreissman, Susan G.; Hogarty, Michael; Matthay, Katherine K.; DuBois, Steven G. 分享 收藏
分享 收藏
The Genetics of Splicing in Neuroblastoma Chen, Justin; Hackett, Christopher S.; Zhang, Shile; Song, Young K.; Bell, Robert J. A.; Molinaro, Annette M.; Quigley, David A.; Balmain, Allan; Song, Jun S.; Costello, Joseph F.; Gustafson, W. Clay; Van Dyke, Terry; Kwok, Pui-Yan; Khan, Javed; Weiss, William A. 分享 收藏
Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma Hackett, Christopher S.; Quigley, David A.; Wong, Robyn A.; Chen, Justin; Cheng, Christine; Song, Young K.; Wei, Jun S.; Pawlikowska, Ludmila; Bao, Yun; Goldenberg, David D.; Kim Nguyen; Gustafson, W. Clay; Rallapalli, Sundari K.; Cho, Yoon-Jae; Cook, James M.; Kozlov, Serguei; Mao, Jian-Hua; Van Dyke, Terry; Kwok, Pui-Yan; Khan, Javed; Balmain, Allan; Fan, QiWen; Weiss, William A. 分享 收藏
分享 收藏
Preclinical development of meta1211At] astatobenzylguanidine ([211At] MABG) targeted radiotherapy for neuroblastoma Batra, V.; Chacko, A. M.; Gagliardi, M.; Hou, C.; Mikitsh, J. L.; Freifelder, R. H.; Kachur, A.; LeGeyt, B. C.; Schmitz, A.; Toto, L.; Vaidyanathan, G.; Zalutsky, M. R.; Matthay, K. K.; Weiss, W. A.; Gustafson, W. C.; Pryma, D.; Maris, J. M. 分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
