未登录 The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals 强效的人类CAR激动剂CITCO是人体化组成型雄烷受体小鼠中的非遗传毒性肝肿瘤促进剂，但不是野生型动物中的。 Henderson, C. J.; Mclaren, A. W.; Macleod, A. K.; Lin, D.; Cameron, A. R.; Chatham, L. R.; Moggs, J.; Inesta-Vaquera, F.; Thomson, John P.; Meehan, Richard R.; Chakravarty, P.; Schwarz, M.; Wolf, C. Roland 分享 收藏
Unaltered hepatic wound healing response in male rats with ancestral liver injury Beil, Johanna; Perner, Juliane; Pfaller, Lena; Gerard, Marie-Apolline; Piaia, Alessandro; Doelemeyer, Arno; Wasserkrug Naor, Adi; Martin, Lori; Piequet, Aline; Dubost, Valerie; Chibout, Salah-Dine; Moggs, Jonathan; Terranova, Remi 分享 收藏
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Using human genetics to improve safety assessment of therapeutics 利用人类遗传学改善治疗药物的安全性评估 Carss, Keren J.; Deaton, Aimee M.; Del Rio-Espinola, Alberto; Diogo, Dorothee; Fielden, Mark; Kulkarni, Diptee A.; Moggs, Jonathan; Newham, Peter; Nelson, Matthew R.; Sistare, Frank D.; Ward, Lucas D.; Yuan, Jing 分享 收藏
Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies Huang, Ying; Sendzik, Martin; Zhang, Jeff; Gao, Zhenting; Sun, Yongfeng; Wang, Long; Gu, Justin; Zhao, Kehao; Yu, Zhengtian; Zhang, Lijun; Zhang, Qiong; Blanz, Joachim; Chen, Zijun; Dubost, Valerie; Fang, Douglas; Feng, Lijian; Fu, Xingnian; Kiffe, Michael; Li, Ling; Luo, Fangjun; Luo, Xiao; Mi, Yuan; Mistry, Prakash; Pearson, David; Piaia, Alessandro; Scheufler, Clemens; Terranova, Remi; Weiss, Andreas; Zeng, Jue; Zhang, Hailong; Zhang, Jiangwei; Zhao, Mengxi; Dillon, Michael P.; Jeay, Sebastien; Qi, Wei; Moggs, Jonathan; Pissot-Soldermann, Carole; Li, En; Atadja, Peter; Lingel, Andreas; Oyang, Counde 分享 收藏
The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels (vol 17, e1009726, 2021) Axelsson, Erik; Ljungvall, Ingrid; Bhoumik, Priyasma; Conn, Laura Bas; Muren, Eva; Ohlsson, Asa; Olsen, Lisbeth Hoier; Engdahl, Karolina; Hagman, Ragnvi; Hanson, Jeanette; Kryvokhyzha, Dmytro; Pettersson, Mats; Grenet, Olivier; Moggs, Jonathan; Del Rio-Espinola, Alberto; Epe, Christian; Taillon, Bruce; Tawari, Nilesh; Mane, Shrinivas; Hawkins, Troy; Hedhammar, Ake; Gruet, Philippe; Haggstrom, Jens; Lindblad-Toh, Kerstin 分享 收藏
The genetic consequences of dog breed formation-Accumulation of deleterious genetic variation and fixation of mutations associated with myxomatous mitral valve disease in cavalier King Charles spaniels Axelsson, Erik; Ljungvall, Ingrid; Bhoumik, Priyasma; Conn, Laura Bas; Muren, Eva; Ohlsson, Asa; Olsen, Lisbeth Hoier; Engdahl, Karolina; Hagman, Ragnvi; Hanson, Jeanette; Kryvokhyzha, Dmytro; Pettersson, Mats; Grenet, Olivier; Moggs, Jonathan; Del Rio-Espinola, Alberto; Epe, Christian; Taillon, Bruce; Tawari, Nilesh; Mane, Shrinivas; Hawkins, Troy; Hedhammar, Ake; Gruet, Philippe; Haggstrom, Jens; Lindblad-Toh, Kerstin 分享 收藏
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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective Reynolds, Vincent L.; Butler, Paul; Abernathy, Matthew M.; Aschenbrenner, Laura; Best, Derek D.; Blank, Jim; Crosby, Meredith; Custer, Laura; Escobar, Patricia A.; Kolaja, Kyle; Moggs, Jonathan; Shuey, Dana; Snyder, Chelsea; Van Vleet, Terry; Zhou, Junguo; Hart, Timothy K. 分享 收藏
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Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion Vitobello, Antonio; Perner, Juliane; Beil, Johanna; Zhu, Jiang; Del Rio-Espinola, Alberto; Morawiec, Laurent; Westphal, Magdalena; Dubost, Valerie; Altorfer, Marc; Naumann, Ulrike; Mueller, Arne; Kapur, Karen; Borowsky, Mark; Henderson, Colin; Wolf, C. Roland; Schwarz, Michael; Moggs, Jonathan; Terranova, Remi 分享 收藏
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Human relevance of rodent liver tumors: Key insights from a Toxicology Forum workshop on nongenotoxic modes of action Felter, Susan P.; Foreman, Jennifer E.; Boobis, Alan; Corton, J. Christopher; Doi, Adriana M.; Flowers, Lynn; Goodman, Jay; Haber, Lynne T.; Jacobs, Abigail; Klaunig, James E.; Lynch, Angela M.; Moggs, Jonathan; Pandiri, Arun 分享 收藏
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Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver Pouche, Lucie; Vitobello, Antonio; Roemer, Michael; Glogovac, Milica; MacLeod, A. Kenneth; Ellinger-Ziegelbauer, Heidrun; Westphal, Magdalena; Dubost, Valerie; Stiehl, Daniel Philipp; Dumotier, Berengere; Fekete, Alexander; Moulin, Pierre; Zell, Andreas; Schwarz, Michael; Moreno, Rita; Huang, Jeffrey T. J.; Elcombe, Cliff R.; Henderson, Colin J.; Wolf, C. Roland; Moggs, Jonathan G.; Terranova, Remi 分享 收藏
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Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer Thomson, John P.; Ottaviano, Raffaele; Unterberger, Elif B.; Lempiainen, Harri; Muller, Arne; Terranova, Remi; Illingworth, Robert S.; Webb, Shaun; Kerr, Alastair R. W.; Lyall, Marcus J.; Drake, Amanda J.; Wolf, C. Roland; Moggs, Jonathan G.; Schwarz, Michael; Meehan, Richard R. 分享 收藏
Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome Brasa, Sarah; Mueller, Arne; Jacquemont, Sebastien; Hahne, Florian; Rozenberg, Izabela; Peters, Thomas; He, Yunsheng; McCormack, Christine; Gasparini, Fabrizio; Chibout, Salah-Dine; Grenet, Olivier; Moggs, Jonathan; Gomez-Mancilla, Baltazar; Terranova, Remi 分享 收藏
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Importance of investigating epigenetic alterations for industry, and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute Miousse, Isabelle R.; Currie, Richard; Datta, Kaushik; Ellinger-Ziegelbauer, Heidrun; French, John E.; Harrill, Alison H.; Koturbash, Igor; Lawton, Michael; Mann, Derek; Meehan, Richard R.; Moggs, Jonathan G.; O'Lone, Raegan; Rasoulpour, Reza J.; Pera, Renee A. Reijo; Thompson, Karol 分享 收藏
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