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Huntingtin contains an ubiquitin- binding domain and regulates lysosomal targeting of mitochondrial and RNA- binding proteins 亨廷顿蛋白包含一个泛素结合域，并调节线粒体和RNA结合蛋白的溶酶体靶向 Fote, Gianna M.; V. Eapen, Vinay; Lim, Ryan G.; Yu, Clinton; Salazar, Lisa; Mcclure, Nicolette R.; Mcknight, Jharrayne; Nguyen, Thai B.; Heath, Marie C.; Lau, Alice L.; Villamil, Mark A.; Miramontes, Ricardo; Kratter, Ian H.; Finkbeiner, Steven; Reidling, Jack C.; Paulo, Joao A.; Kaiser, Peter; Huang, Lan; Housman, David E.; Thompson, Leslie M.; Steffan, Joan S. 分享 收藏
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Fatty acid synthesis is required for breast cancer brain metastasis (vol 2, pg 414, 2021) Ferraro, Gino B.; Ali, Ahmed; Luengo, Alba; Kodack, David P.; Deik, Amy; Abbott, Keene L.; Bezwada, Divya; Blanc, Landry; Prideaux, Brendan; Jin, Xin; Posada, Jessica M.; Chen, Jiang; Chin, Christopher R.; Amoozgar, Zohreh; Ferreira, Raphael; Chen, Ivy X.; Naxerova, Kamila; Ng, Christopher; Westermark, Anna M.; Duquette, Mark; Roberge, Sylvie; Lindeman, Neal I.; Lyssiotis, Costas A.; Nielsen, Jens; Housman, David E.; Duda, Dan G.; Brachtel, Elena; Golub, Todd R.; Cantley, Lewis C.; Asara, John M.; Davidson, Shawn M.; Fukumura, Dai; Dartois, Veronique A.; Clish, Clary B.; Jain, Rakesh K.; Vander Heiden, Matthew G. 分享 收藏
CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors Crittenden, Jill R.; Zhai, Shenyu; Sauvage, Magdalena; Kitsukawa, Takashi; Burguiere, Eric; Thomsen, Morgane; Zhang, Hui; Costa, Cinzia; Martella, Giuseppina; Ghiglieri, Veronica; Picconi, Barbara; Pescatore, Karen A.; Unterwald, Ellen M.; Jackson, Walker S.; Housman, David E.; Caine, S. Barak; Sulzer, David; Calabresi, Paolo; Smith, Anne C.; Surmeier, D. James; Graybiel, Ann M. 分享 收藏
Fatty acid synthesis is required for breast cancer brain metastasis 脂肪酸合成是乳腺癌脑转移所必需的 Ferraro, Gino B.; Ali, Ahmed; Luengo, Alba; Kodack, David P.; Deik, Amy; Abbott, Keene L.; Bezwada, Divya; Blanc, Landry; Prideaux, Brendan; Jin, Xin; Possada, Jessica M.; Chen, Jiang; Chin, Christopher R.; Amoozgar, Zohreh; Ferreira, Raphael; Chen, Ivy X.; Naxerova, Kamila; Ng, Christopher; Westermark, Anna M.; Duquette, Mark; Roberge, Sylvie; Lindeman, Neal I.; Lyssiotis, Costas A.; Nielsen, Jens; Housman, David E.; Duda, Dan G.; Brachtel, Elena; Golub, Todd R.; Cantley, Lewis C.; Asara, John M.; Davidson, Shawn M.; Fukumura, Dai; Dartois, Veronique A.; Clish, Clary B.; Jain, Rakesh K.; Vander Heiden, Matthew G. 分享 收藏
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Early epigenomic and transcriptional changes reveal Elk-1 transcription factor as a therapeutic target in Huntington's disease 早期表观基因组和转录变化揭示了Elk-1转录因子作为亨廷顿病的治疗靶点 Yildirim, Ferah; Ng, Christopher W.; Kappes, Vincent; Ehrenberger, Tobias; Rigby, Siobhan K.; Stivanello, Victoria; Gipson, Theresa A.; Soltis, Anthony R.; Vanhoutte, Peter; Caboche, Jocelyne; Housman, David E.; Fraenkel, Ernest 分享 收藏
IKKβ slows Huntington's disease progression in R6/1 mice Ikk β 减缓R6/1小鼠的亨廷顿舞蹈病进展 Ochaba, Joseph; Fote, Gianna; Kachemov, Marketta; Thein, Soe; Yeung, Sylvia Y.; Lau, Alice L.; Hernandez, Sarah; Lim, Ryan G.; Casale, Malcolm; Neel, Michael J.; Monuki, Edwin S.; Reidling, Jack; Housman, David E.; Thompson, Leslie M.; Steffan, Joan S. 分享 收藏
Transcriptome alterations in myotonic dystrophy skeletal muscle and heart Wang, Eric T.; Treacy, Daniel; Eichinger, Katy; Struck, Adam; Estabrook, Joseph; Olafson, Hailey; Wang, Thomas T.; Bhatt, Kirti; Westbrook, Tony; Sedehizadeh, Sam; Ward, Amanda; Day, John; Brook, David; Berglund, J. Andrew; Cooper, Thomas; Housman, David; Thornton, Charles; Burge, Christopher 分享 收藏
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Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis Fratta, Pietro; Sivakumar, Prasanth; Humphrey, Jack; Lo, Kitty; Ricketts, Thomas; Oliveira, Hugo; Brito-Armas, Jose M.; Kalmar, Bernadett; Ule, Agnieszka; Yu, Yichao; Birsa, Nicol; Bodo, Cristian; Collins, Toby; Conicella, Alexander E.; Maza, Alan Mejia; Marrero-Gagliardi, Alessandro; Stewart, Michelle; Mianne, Joffrey; Corrochano, Silvia; Emmett, Warren; Codner, Gemma; Groves, Michael; Fukumura, Ryutaro; Gondo, Yoichi; Lythgoe, Mark; Pauws, Erwin; Peskett, Emma; Stanier, Philip; Teboul, Lydia; Hallegger, Martina; Calvo, Andrea; Chio, Adriano; Isaacs, Adrian M.; Fawzi, Nicolas L.; Wang, Eric; Housman, David E.; Baralle, Francisco; Greensmith, Linda; Buratti, Emanuele; Plagnol, Vincent; Fisher, Elizabeth M. C.; Acevedo-Arozena, Abraham 分享 收藏
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Detection of long repeat expansions from PCR-free whole-genome sequence data 从无PCR的全基因组序列数据中检测长重复扩增 Dolzhenko, Egor; van Vugt, Joke J. F. A.; Shaw, Richard J.; Bekritsky, Mitchell A.; van Blitterswijk, Marka; Narzisi, Giuseppe; Ajay, Subramanian S.; Rajan, Vani; Lajoie, Bryan R.; Johnson, Nathan H.; Kingsbury, Zoya; Humphray, Sean J.; Schellevis, Raymond D.; Brands, William J.; Baker, Matt; Rademakers, Rosa; Kooyman, Maarten; Tazelaar, Gijs H. P.; van Es, Michael A.; McLaughlin, Russell; Sproviero, William; Shatunov, Aleksey; Jones, Ashley; Al Khleifat, Ahmad; Pittman, Alan; Morgan, Sarah; Hardiman, Orla; Al-Chalabi, Ammar; Shaw, Chris; Smith, Bradley; Neo, Edmund J.; Morrison, Karen; Shaw, Pamela J.; Reeves, Catherine; Winterkorn, Lara; Wexler, Nancy S.; Housman, David E.; Ng, Christopher W.; Li, Alina L.; Taft, Ryan J.; van den Berg, Leonard H.; Bentley, David R.; Veldink, Jan H.; Eberle, Michael A. 分享 收藏
A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia 有缺陷的mRNA切割和聚腺苷酸化复合物促进了与Friedreich共济失调相关的转录 (GAA)n重复序列的扩增 McGinty, Ryan J.; Puleo, Franco; Aksenova, Anna Y.; Hisey, Julia A.; Shishkin, Alexander A.; Pearson, Erika L.; Wang, Eric T.; Housman, David E.; Moore, Claire; Mirkin, Sergei M. 分享 收藏
Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits Lim, Ryan G.; Quan, Chris; Reyes-Ortiz, Andrea M.; Lutz, Sarah E.; Kedaigle, Amanda J.; Gipson, Theresa A.; Wu, Jie; Vatine, Gad D.; Stocksdale, Jennifer; Casale, Malcolm S.; Svendsen, Clive N.; Fraenkel, Ernest; Housman, David E.; Agalliu, Dritan; Thompson, Leslie M. 分享 收藏
Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons Crittenden, Jill R.; Tillberg, Paul W.; Riad, Michael H.; Shima, Yasuyuki; Gerfen, Charles R.; Curry, Jeffrey; Housman, David E.; Nelson, Sacha B.; Boyden, Edward S.; Graybiel, Ann M. 分享 收藏
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features Ouyang, Qing; Nakayama, Tojo; Baytas, Ozan; Davidson, Shawn M.; Yang, Chendong; Schmidt, Michael; Lizarraga, Sofia B.; Mishra, Sasmita; EI-Quessny, Malak; Niaz, Saima; Butt, Mirrat Gul; Murtaza, Syed Imran; Javed, Afzal; Chaudhry, Haroon Rashid; Vaughan, Dylan J.; Hill, R. Sean; Partlow, Jennifer N.; Yoo, Seung-Yun; Lam, Anh-Thu N.; Nasir, Ramzi; Al-Saffar, Muna; Barkovich, A. James; Schwede, Matthew; Nagpal, Shailender; Rajab, Anna; DeBerardinis, Ralph J.; Housman, David E.; Mochida, Ganeshwaran H.; Morrow, Eric M. 分享 收藏
Potential function for the Huntingtin protein as a scaffold for selective autophagy 亨廷顿蛋白作为选择性自噬支架的潜在功能 Ochaba, Joseph; Lukacsovich, Tamas; Csikos, George; Zheng, Shuqiu; Margulis, Julia; Salazar, Lisa; Mao, Kai; Lau, Alice L.; Yeung, Sylvia Y.; Humbert, Sandrine; Saudou, Frederic; Klionsky, Daniel J.; Finkbeiner, Steven; Zeitlin, Scott O.; Marsh, J. Lawrence; Housman, David E.; Thompson, Leslie M.; Steffan, Joan S. 分享 收藏
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