未登录 A phase Ib dose-expansion study of porustobart, an anti-CTLA-4 heavy chain only monoclonal antibody, in combination with toripalimab in patients with advanced high-grade neuroendocrine neoplasms (NENs) Lu, Ming; Zhang, Panpan; Shen, Lin; Chen, Kai; Yang, Jianwei; Song, Lijie; Gardner, Humphrey; Lin, Kedan; Ding, Luyin; Zhao, Shuai; Geng, Yuan; Ding, Jie; Lu, Zailian; Wang, Yedong 分享 收藏
Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties Ovacik, Ayse Meric; Li, Ji; Lemper, Marie; Danilenko, Dimitry; Stagg, Nicola; Mathieu, Mary; Ellerman, Diego; Gupta, Vinita; Kalia, Navdeep; Trung Nguy; Plaks, Vicki; Johnson, Clarissa David; Wang, Weiru; Brumm, Jochen; Fine, Bernard; Junttila, Teemu; Lin, Kedan; Carter, Paul J.; Prabhu, Saileta; Spiess, Christoph; Kamath, Amrita V. 分享 收藏
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Anti-NaPi2b antibody-drug conjugate lifastuzumab vedotin (DNIB0600A) compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer in a randomized, open-label, phase II study Anti-NaPi2b抗体药物偶联物利法妥珠单抗维多汀 (DNIB0600A) 与聚乙二醇化脂质体多柔比星在铂类耐药卵巢癌患者中的随机，开放标签，II期研究 Banerjee, S.; Oza, A. M.; Birrer, M. J.; Hamilton, E. P.; Hasan, J.; Leary, A.; Moore, K. N.; Mackowiak-Matejczyk, B.; Pikiel, J.; Ray-Coquard, I.; Trask, P.; Lin, K.; Schuth, E.; Vaze, A.; Choi, Y.; Marsters, J. C.; Maslyar, D. J.; Lemahieu, V.; Wang, Y.; Humke, E. W.; Liu, J. F. 分享 收藏
Relative Target Affinities of T-Cell-Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model T细胞依赖性双特异性抗体的相对靶标亲和力决定了实体瘤小鼠模型中的生物分布 Mandikian, Danielle; Takahashi, Nene; Lo, Amy A.; Li, Ji; Eastham-Anderson, Jeffrey; Slaga, Dionysos; Ho, Jason; Hristopoulos, Maria; Clark, Robyn; Totpal, Klara; Lin, Kedan; Joseph, Sean B.; Dennis, Mark S.; Prabhu, Saileta; Junttila, Teemu T.; Boswell, C. Andrew 分享 收藏
Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells Dillon, Michael; Yin, Yiyuan; Zhou, Jianhui; McCarty, Luke; Ellerman, Diego; Slaga, Dionysos; Junttila, Teemu T.; Han, Guanghui; Sandoval, Wendy; Ovacik, Meric A.; Lin, Kedan; Hu, Zhilan; Shen, Amy; Corn, Jacob E.; Spiess, Christoph; Carter, Paul J. 分享 收藏
Development and Translational Application of an Integrated, Mechanistic Model of Antibody-Drug Conjugate Pharmacokinetics 抗体-药物缀合物药代动力学的集成机制模型的开发和翻译应用 Sukumaran, Siddharth; Zhang, Crystal; Leipold, Douglas D.; Saad, Ola M.; Xu, Keyang; Gadkar, Kapil; Samineni, Divya; Wang, Bei; Milojic-Blair, Marija; Carrasco-Triguero, Montserrat; Rubinfeld, Bonnee; Fielder, Paul; Lin, Kedan; Ramanujan, Saroja 分享 收藏
Mechanism-Based Pharmacokinetic/Pharmacodynamic Model for THIOMAB™ Drug Conjugates Sukumaran, Siddharth; Gadkar, Kapil; Zhang, Crystal; Bhakta, Sunil; Liu, Luna; Xu, Keyang; Raab, Helga; Yu, Shang-Fan; Mai, Elaine; Fourie-O'Donohue, Aimee; Kozak, Katherine R.; Ramanujan, Saroja; Junutula, Jagath R.; Lin, Kedan 分享 收藏
Total Antibody Quantification for MMAE-Conjugated Antibody-Drug Conjugates: Impact of Assay Format and Reagents Kozak, Katherine R.; Tsai, Siao Ping; Fourie-O'Donohue, Aimee; Chuh, Josefa dela Cruz; Roth, Leslie; Cook, Ryan; Chan, Elton; Chan, Pamela; Darwish, Martine; Ohri, Rachana; Raab, Helga; Zhang, Crystal; Lin, Kedan; Wong, Wai Lee T. 分享 收藏
Preclinical development of anti-SLC34A2 antibody drug conjugate as a therapeutic for non-small cell lung and ovarian cancers. Lin, Kedan; Zhang, Crystal; Harstad, Eric; Hiraragi, Hajime; Solis, Willy; Tsai, Siao Ping; Xu, Keyang; Hristopoulos, Maria; Venook, Rayna; Rubinfeld, Bonnee; Polakis, Paul 分享 收藏
Micro-volume wall-less immunoassays using patterned planar plates Kozak, Katherine R.; Wang, Jianyong; Lye, Melvin; Chuh, Josefa dela Cruz; Takkar, Rashi; Kim, Namyong; Lee, Hyunjae; Jeon, Noo Li; Lin, Kedan; Zhang, Crystal; Wong, Wai Lee T.; DeForge, Laura E. 分享 收藏
An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2 Boswell, C. Andrew; Mundo, Eduardo E.; Firestein, Ron; Zhang, Crystal; Mao, Weiguang; Gill, Herman; Young, Cynthia; Ljumanovic, Nina; Stainton, Shannon; Ulufatu, Sheila; Fourie, Aimee; Kozak, Katherine R.; Fuji, Reina; Polakis, Paul; Khawli, Leslie A.; Lin, Kedan 分享 收藏
Differential Effects of Predosing on Tumor and Tissue Uptake of an 111In-Labeled Anti-TENB2 Antibody-Drug Conjugate Boswell, C. Andrew; Mundo, Eduardo E.; Zhang, Crystal; Stainton, Shannon L.; Yu, Shang-Fan; Lacap, Jennifer A.; Mao, Weiguang; Kozak, Katherine R.; Fourie, Aimee; Polakis, Paul; Khawli, Leslie A.; Lin, Kedan 分享 收藏
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Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody-Drug Conjugates in Rats Boswell, C. Andrew; Mundo, Eduardo E.; Zhang, Crystal; Bumbaca, Daniela; Valle, Nicole R.; Kozak, Katherine R.; Fourie, Aimee; Chuh, Josefa; Koppada, Neelima; Saad, Ola; Gill, Herman; Shen, Ben-Quan; Rubinfeld, Bonnee; Tibbitts, Jay; Kaur, Surinder; Theil, Frank-Peter; Fielder, Paul J.; Khawli, Leslie A.; Lin, Kedan 分享 收藏
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