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Glue-Tiful Inhibitors: Cyclic Depsipeptides Enhance Protein-Protein Interaction within the Subunits Heterotrimeric Gq/11 Proteins 粘合素样抑制剂：环状脱肽有助于增强异三聚体Gq/11蛋白亚基间的蛋白质-蛋白质相互作用 Juergenliemke, Lars; Alenfelder, Judith; Schihada, Hannes; Muhle, Jonas; Rodrigues, Matthew j.; Guixa-gonzalez, Ramon; Crusemann, Max; Konig, Gabriele m.; Schertler, Gebhard fx.; Kostenis, Evi; Deupi, Xavier 分享 收藏
Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension Seidinger, Alexander; Roberts, Richard; Bai, Yan; Mueller, Marion; Pfeil, Eva; Matthey, Michaela; Rieck, Sarah; Alenfelder, Judith; Koenig, Gabriele M.; Pfeifer, Alexander; Kostenis, Evi; Klinke, Anna; Fleischmann, Bernd K.; Wenzel, Daniela 分享 收藏
GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism Matthees, Edda S. F.; Filor, Jenny C.; Jaiswal, Natasha; Reichel, Mona; Youssef, Noureldine; D'Uonnolo, Giulia; Szpakowska, Martyna; Drube, Julia; Koenig, Gabriele M.; Kostenis, Evi; Chevigne, Andy; Godbole, Amod; Hoffmann, Carsten 分享 收藏
Structural response of G protein binding to the cyclodepsipeptide inhibitor FR900359 probed by NMR spectroscopy Bonifer, Christian; Hanke, Wiebke; Muehle, Jonas; Loehr, Frank; Becker-Baldus, Johanna; Nagel, Jessica; Schertler, Gebhard F. X.; Mueller, Christa E.; Koenig, Gabriele M.; Hilger, Daniel; Glaubitz, Clemens 分享 收藏
Biosynthesis of the corallorazines, a widespread class of antibiotic cyclic lipodipeptides Dreckmann, Teresa M.; Fritz, Lisa; Kaiser, Christian F.; Bouhired, Sarah M.; Wirtz, Daniel A.; Rausch, Marvin; Mueller, Anna; Schneider, Tanja; Koenig, Gabriele M.; Cruesemann, Max 分享 收藏
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Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets 葡萄糖刺激的胰岛素分泌取决于新生小鼠胰岛中的FFA1和Gq Lorza-Gil, Estela; Kaiser, Gabriele; Carlein, Christopher; Hoffmann, Markus D. A.; Koenig, Gabriele M.; Haug, Sieglinde; Roma, Leticia Prates; Ulven, Elisabeth Rexen; Ulven, Trond; Kostenis, Evi; Birkenfeld, Andreas L.; Haering, Hans-Ulrich; Ullrich, Susanne; Gerst, Felicia 分享 收藏
Selective optogenetic control of Gq signaling using human Neuropsin (vol 13, 1765, 2022) Wagdi, Ahmed; Malan, Daniela; Sathyanarayanan, Udhayabhaskar; Beauchamp, Janosch S.; Vogt, Markus; Zipf, David; Beiert, Thomas; Mansuroglu, Berivan; Dusend, Vanessa; Meininghaus, Mark; Schneider, Linn; Kalthof, Bernd; Wiegert, J. Simon; Koenig, Gabriele M.; Kostenis, Evi; Patejdl, Robert; Sasse, Philipp; Bruegmann, Tobias 分享 收藏
Pharmacokinetics and Pharmacodynamics (PK/PD) of Corallopyronin A against Methicillin-Resistant Staphylococcus aureus Corallopyronin A对耐甲氧西林金黄色葡萄球菌的药代动力学和药效学 (PK/PD) Rox, Katharina; Becker, Tim; Schiefer, Andrea; Grosse, Miriam; Ehrens, Alexandra; Jansen, Rolf; Aden, Tilman; Kehraus, Stefan; Koenig, Gabriele M.; Krome, Anna K.; Huebner, Marc P.; Wagner, Karl G.; Stadler, Marc; Pfarr, Kenneth; Hoerauf, Achim 分享 收藏
Imaging of Gαq Proteins in Mouse and Human Organs and Tissues Voss, Jan H.; Al-Hroub, Haneen; Gedschold, Robin; Dietrich, Jennifer M.; Gaffal, Evelyn; Toma, Marieta; Kehraus, Stefan; Koenig, Gabriele M.; Brust, Peter; Fleischmann, Bernd K.; Wenzel, Daniela; Deuther-Conrad, Winnie; Mueller, Christa E. 分享 收藏
In Vitro-In Vivo Relationship in Mini-Scale-Enabling Formulations of Corallopyronin A Becker, Tim; Krome, Anna K.; Vahdati, Sahel; Schiefer, Andrea; Pfarr, Kenneth; Ehrens, Alexandra; Aden, Tilman; Grosse, Miriam; Jansen, Rolf; Alt, Silke; Hesterkamp, Thomas; Stadler, Marc; Huebner, Marc P.; Kehraus, Stefan; Koenig, Gabriele M.; Hoerauf, Achim; Wagner, Karl G. 分享 收藏
The RNA Polymerase Inhibitor Corallopyronin A Has a Lower Frequency of Resistance Than Rifampicin in Staphylococcus aureus Balansky, Jan; Pfarr, Kenneth; Szekat, Christiane; Kehraus, Stefan; Aden, Tilman; Grosse, Miriam; Jansen, Rolf; Hesterkamp, Thomas; Schiefer, Andrea; Koenig, Gabriele M.; Stadler, Marc; Hoerauf, Achim; Bierbaum, Gabriele 分享 收藏
Selective optogenetic control of Gq signaling using human Neuropsin Wagdi, Ahmed; Malan, Daniela; Sathyanarayanan, Udhayabhaskar; Beauchamp, Janosch S.; Vogt, Markus; Zipf, David; Beiert, Thomas; Mansuroglu, Berivan; Dusend, Vanessa; Meininghaus, Mark; Schneider, Linn; Kalthof, Bernd; Wiegert, J. Simon; Konig, Gabriele M.; Kostenis, Evi; Patejdl, Robert; Sasse, Philipp; Bruegmann, Tobias 分享 收藏
Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice 脂肪细胞Gq信号是小鼠葡萄糖和脂质稳态的调节剂 Kimura, Takefumi; Pydi, Sai P.; Wang, Lei; Haspula, Dhanush; Cui, Yinghong; Lu, Huiyan; Koenig, Gabriele M.; Kostenis, Evi; Steinberg, Gregory R.; Gavrilova, Oksana; Wess, Juergen 分享 收藏
Corallopyronin A: antimicrobial discovery to preclinical development Krome, Anna K.; Becker, Tim; Kehraus, Stefan; Schiefer, Andrea; Gutschow, Michael; Chaverra-Munoz, Lillibeth; Huttel, Stephan; Jansen, Rolf; Stadler, Marc; Ehrens, Alexandra; Pogorevc, Domen; Muller, Rolf; Hubner, Marc P.; Hesterkamp, Thomas; Pfarr, Kenneth; Hoerauf, Achim; Wagner, Karl G.; Konig, Gabriele M. 分享 收藏
Gq signaling in α cells is critical for q maintaining euglycemia Liu, Liu; Dattaroy, Diptadip; Simpson, Katherine F.; Barella, Luiz F.; Cui, Yinghong; Xiong, Yan; Jin, Jian; Konig, Gabriele M.; Kostenis, Evi; Roman, Jefferey C.; Kaestner, Klaus H.; Doliba, Nicolai M.; Wess, Jurgen 分享 收藏
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors Voss, Jan H.; Nagel, Jessica; Rafehi, Muhammad; Guixa-Gonzalez, Ramon; Malfacini, Davide; Patt, Julian; Kehraus, Stefan; Inoue, Asuka; Koenig, Gabriele M.; Kostenis, Evi; Deupi, Xavier; Namasivayam, Vigneshwaran; Mueller, Christa E. 分享 收藏
Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries 局部IP3受体介导的Ca2信号化合物可指导脑毛细血管中的血流 Longden, Thomas A.; Mughal, Amreen; Hennig, Grant W.; Harraz, Osama F.; Shui, Bo; Lee, Frank K.; Lee, Jane C.; Reining, Shaun; Kotlikoff, Michael, I; Konig, Gabriele M.; Kostenis, Evi; Hill-Eubanks, David; Nelson, Mark T. 分享 收藏
Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives Hanke, Wiebke; Patt, Julian; Alenfelder, Judith; Voss, Jan H.; Zdouc, Mitja M.; Kehraus, Stefan; Kim, Jung Bong; Grujicic, Goran, V; Namasivayam, Vigneshwaran; Reher, Raphael; Mueller, Christa E.; Kostenis, Evi; Cruesemann, Max; Koenig, Gabriele M. 分享 收藏
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