Zhufang Shen

Chinese Academy of Medical Sciences and Peking Union Medical College

H指数:31

被引数:3,201

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Integration of Metabolomics; Transcriptomics; and 16s rRNA Sequencing Reveals the Mechanism of Morus alba L. (Sangzhi) Alkaloids (SZ-A) in Improving Cholesterol Metabolism in Diabetic Rats

代谢组学、转录组学和16S rRNA测序的整合揭示了Morus alba L.（桑枝）生物碱（SZ-A）改善糖尿病大鼠胆固醇代谢的机制

ACS Omega

IF4.3

2025-07-300

The GPR40 novel agonist SZZ15-11 improves non-alcoholic fatty liver disease by activating the AMPK pathway and restores metabolic homeostasis in diet-induced obese mice

GPR40新型激动剂SZZ15-11通过激活AMPK通路改善非酒精性脂肪性肝病，并恢复饮食诱导的肥胖小鼠的代谢稳态

DIABETES OBESITY & METABOLISM

IF5.7

2024-03-181

PRE

Proportion of participants with type 2 diabetes achieving a metabolic composite endpoint with once-weekly semaglutide treatment versus comparators: Post hoc pooled analysis from SUSTAIN 1-5, 7-10 and SUSTAIN China

DIABETES OBESITY & METABOLISM

IF5.7

2023-10-122

New anti-diabetic drug Morus alba L. (Sangzhi) alkaloids (SZ-A) improves diabetic nephropathy through ameliorating inflammation and fibrosis in diabetic rats

FRONTIERS IN MEDICINE

IF3

2023-06-095

OAAI

Machine learning- and structure-based discovery of a novel chemotype as FXR agonists for potential treatment of nonalcoholic fatty liver disease

基于机器学习和结构的新型化学型发现，作为FXR激动剂，用于潜在治疗非酒精性脂肪性肝病

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-04-017

PRE

Microbial biotransformation to obtain stilbene methylglucoside with GPR119 agonistic activity

FRONTIERS IN MICROBIOLOGY

IF4.5

2023-03-223

OAAI

Structural optimization and biological evaluation of 1-adamantylcarbo-nyl-4-phenylpiperazine derivatives as FXR agonists for NAFLD

1-金刚烷基羰基-4-苯基哌嗪衍生物作为NAFLD的FXR激动剂的结构优化和生物学评价

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-01-017

PRE

Discovery of Novel Indole Derivatives as Fructose-1,6-bisphosphatase Inhibitors and X-ray Cocrystal Structures Analysis

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-12-206

Berberine combined with stachyose improves glycometabolism and gut microbiota through regulating colonic microRNA and gene expression in diabetic rats

LIFE SCIENCES

IF5.1

2021-11-0118

OAAI

Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial

DIABETES CARE

IF16.6

2021-04-0840

Diphenyl diselenide alleviates diabetic peripheral neuropathy in rats with streptozotocin-induced diabetes by modulating oxidative stress

BIOCHEMICAL PHARMACOLOGY

IF5.6

2020-12-0132

PREAI

Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2020-11-018

PREAI

The Chinese patent medicine, Jin-tang-ning, ameliorates hyperglycemia through in proving β cell function in pre-diabetic KKAy mice

CHINESE JOURNAL OF NATURAL MEDICINES

IF4.9

2020-11-015

PREAI

Discovery of N-Arylsulfonyl-Indole-2-Carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors-Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-08-2116

PREAI

Effects of a ready-to-eat cereal formula powder on glucose metabolism, inflammation, and gut microbiota in diabetic db/db mice

FOOD SCIENCE & NUTRITION

IF3.8

2020-06-295

The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-02-0125

PREAI

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

PHYTOTHERAPY RESEARCH

IF6.3

2019-12-1345

OAAI

Effects of metformin on metabolism of white and brown adipose tissue in obese C57BL/6J mice

DIABETOLOGY & METABOLIC SYNDROME

IF3.9

2019-11-2720

OAAI

A novel specific peroxisome proliferator-activated receptor γ (PPARγ) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice

DIABETES OBESITY & METABOLISM

IF5.7

2019-09-0520

OAAI

Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking

MOLECULES

IF4.6

2019-05-0843

OAAI

Zhufang Shen

个人简介

教育背景

工作经历

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