Jeffrey Settleman - Publications, H-index & Citations

Jeffrey Settleman

roche holding

81H指数

422论文数

4.0W被引数

收录论文 100

发表时间

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-29

201

OAAI

Vincent, S; Settleman, J

Activated kras, but not hras or nras, may initiate tumors of endodermal origin via stem cell expansion

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Quinlan, Margaret P.; Quatela, Steven E.; Philips, Mark R.; Settleman, Jeffrey

Regulation of Rho and Rac signaling to the actin cyloskeleton by paxillin during Drosophila development

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Chen, GC; Turano, B; Ruest, PJ; Hagel, M; Settleman, J; Thomas, SA

SHP-2 positively regulates myogenesis by coupling to the rho GTPase signaling pathway

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Kontaridis, MI; Eminaga, S; Fornaro, M; Zito, CI; Sordella, R; Settleman, J; Bennett, AM

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance 系统鉴定癌细胞对自然杀伤细胞介导的免疫监视的脆弱性

ELIFE

IF0

2019-08-27

OAAI

Pech, Matthew; Fong, Linda E.; Villalta, Jacqueline E.; Chan, Leanne J. G.; Kharbanda, Samir; O'Brien, Jonathon J.; McAllister, Fiona E.; Firestone, Ari J.; Jan, Calvin H.; Settleman, Jeffrey

Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity EGFR突变肺癌对酪氨酸激酶抑制剂治疗的获得性耐药促进PARP抑制剂敏感性

CELL REPORTS

IF6.9

2019-06-01

OAAI

Marcar, Lynnette; Bardhan, Kankana; Gheorghiu, Liliana; Dinkelborg, Patrick; Pfaffle, Heike; Liu, Qi; Wang, Meng; Piotrowska, Zofia; Sequist, Lecia V.; Borgmann, Kerstin; Settleman, Jeffrey E.; Engelman, Jeffrey A.; Hata, Aaron N.; Willers, Henning

Challenges in validating candidate therapeutic targets in cancer

ELIFE

IF0

2018-02-08

OAAI

Settleman, Jeffrey; Sawyers, Charles L.; Hunter, Tony

MiR-124 suppresses p62 and p65/NFkB to regulate autophagy, inflammation and cell death in KRAS mutant mesenchymal NSCLC cells

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Mehta, Anita K.; Hua, Kevin; Whipple, William; Mihn-Thuy Nguyen; Perera, Rushika M.; Haybaeck, Johanns; Weidhass, Joanne; Settleman, Jeffrey; Singh, Anurag

Cytoskeletal modulation results in increased tumor survival and drug resistance through attenuation of p53 dependent apoptosis

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Wang, Victoria E.; Doench, John; Root, David; Bernards, Rene; Settleman, Jeffrey; McCormick, Frank

FGFR inhibition re-sensitizes BRAF/MEK dual resistant cells to the BRAF/MEK inhibitor combination

CANCER RESEARCH

IF16.6

2017-07-01

PREAI

Wang, Victoria E.; Settleman, Jeffrey; McCormic, Frank

Taselisib enhances the potency of ERBB inhibitors in biomarker-defined subsets of head and neck squamous carcinoma cell lines

CANCER RESEARCH

IF16.6

2016-07-15

PREAI

Savage, Heidi M.; O'Brien, Carol; Moore, Heather; Lackner, Mark R.; Yauch, Robert; Settleman, Jeffrey; Wilson, Timothy R.

mTOR/S6K pathway-dependent metabolic reprogramming in cancer cells mediates resistance to glycolytic inhibitors

MOLECULAR CANCER RESEARCH

IF4.7

2016-01-01

PREAI

Pusapati, Raju; Gao, Min; Daemen, Anneleen; Hatzivassiliou, Georgia; Settleman, Jeffrey

Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors 代谢物谱分析将胰腺导管腺癌分层为对代谢抑制剂具有不同敏感性的亚型

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-07-27

280

OAAI

Daemen, Anneleen; Peterson, David; Sahu, Nisebita; McCord, Ron; Du, Xiangnan; Liu, Bonnie; Kowanetz, Katarzyna; Hong, Rebecca; Moffat, John; Gao, Min; Boudreau, Aaron; Mroue, Rana; Corson, Laura; O'Brien, Thomas; Qing, Jing; Sampath, Deepak; Merchant, Mark; Yauch, Robert; Manning, Gerard; Settleman, Jeffrey; Hatzivassiliou, Georgia; Evangelista, Marie

Enhancing the antitumor efficacy of a cell-surface death ligand by covalent membrane display 通过共价膜展示增强细胞表面死亡配体的抗肿瘤功效

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-04-20

OAAI

Nair, Pradeep M.; Flores, Heather; Gogineni, Alvin; Marsters, Scot; Lawrence, David A.; Kelley, Robert F.; Ngu, Hai; Sagolla, Meredith; Komuves, Laszlo; Bourgon, Richard; Settleman, Jeffrey; Ashkenazi, Avi

Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors

MOLECULAR CANCER RESEARCH

IF4.7

2015-04-12

OAAI

Kim, Youngjoo; Apetri, Mihaela; Luo, BeiBei; Settleman, Jeffrey E.; Anderson, Karen S.

A comprehensive transcriptional portrait of human cancer cell lines 人类癌细胞系的全面转录肖像

NATURE BIOTECHNOLOGY

IF41.7

2014-12-08

535

PREAI

Klijn, Christiaan; Durinck, Steffen; Stawiski, Eric W.; Haverty, Peter M.; Jiang, Zhaoshi; Liu, Hanbin; Degenhardt, Jeremiah; Mayba, Oleg; Gnad, Florian; Liu, Jinfeng; Pau, Gregoire; Reeder, Jens; Cao, Yi; Mukhyala, Kiran; Selvaraj, Suresh K.; Yu, Mamie; Zynda, Gregory J.; Brauer, Matthew J.; Wu, Thomas D.; Gentleman, Robert C.; Manning, Gerard; Yauch, Robert L.; Bourgon, Richard; Stokoe, David; Modrusan, Zora; Neve, Richard M.; de Sauvage, Frederic J.; Settleman, Jeffrey; Seshagiri, Somasekar; Zhang, Zemin

Explaining the preponderance of Kras mutations in human cancer - An isoform-specific function in stem cell expansion 解释人类癌症中Kras突变的优势-干细胞扩增中的同工型特异性功能

CELL CYCLE

IF3.4

2014-10-28

PREAI

Quinlan, Margaret P.; Settleman, Jeffrey

Inhibition of mutant EGF receptors by Gefitinib - Targeting an Achilles' heel of lung cancer 吉非替尼靶向肺癌阿喀琉斯之踵对突变型EGF受体的抑制作用

CELL CYCLE

IF3.4

2014-10-27

OAAI

Settleman, J