未登录 Pharmacokinetics and Pharmacodynamics of KT-474, a Novel Selective Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults Agarwal, Sagar; Mcdonald, Alice A.; Campbell, Veronica; Chen, Dapeng; Davis, Jeff; Rong, Haojing; Mishkin, Aimee; Slavin, Anthony; Gollerkeri, Ashwin; Gollob, Jared A. 分享 收藏
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Predictive Markers of Response to the MDM2 Degrader KT-253 Dumont, N.; Karnik, R.; Chutake, Y.; Dey, J.; Breitkopf, S.; Howarth, C.; Meeske, C.; Fasciano, A.; Ghilu, S.; Houghton, P.; Mosher, R.; Gollob, J.; Williams, J. 分享 收藏
IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial IRAK4降解剂在化脓性汗腺炎和特应性皮炎中的作用: 1期试验 Ackerman, Lindsay; Acloque, Gerard; Bacchelli, Sandro; Schwartz, Howard; Feinstein, Brian J.; La Stella, Phillip; Alavi, Afsaneh; Gollerkeri, Ashwin; Davis, Jeffrey; Campbell, Veronica; Mcdonald, Alice; Agarwal, Sagar; Karnik, Rahul; Shi, Kelvin; Mishkin, Aimee; Culbertson, Jennifer; Klaus, Christine; Enerson, Bradley; Massa, Virginia; Kuhn, Eric; Sharma, Kirti; Keaney, Erin; Barnes, Randy; Chen, Dapeng; Zheng, Xiaozhang; Rong, Haojing; Sabesan, Vijay; Ho, Chris; Mainolfi, Nello; Slavin, Anthony; Gollob, Jared A. 分享 收藏
STAT3 degraders inhibit cellular activation, cytokine production, and Th17 development, resulting in inhibition of autoimmunity in the MOG-EAE model of CNS inflammation Sullivan, Jeffrey; Brown, Crystal; Mayo, Michele; Dixit, Vaishali; Enerson, Bradley; Rong, Haojing; Yang, Bin; De Savi, Chris; Gollob, Jared; Mainolfi, Nello; Slavin, Anthony; Hubeau, Cedric 分享 收藏
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Degraders targeting both IRAK4 and IMiD substrates show combinatorial effects leading to broader activity with durable and complete regressions in MYD88 mutant lymphoma xenografts in vivo Walker, Duncan H.; Mayo, Michele; Klaus, Christine; Rong, Haojing; Rusin, Scott; Sharma, Kirti; McDonald, Alice; Campbell, Veronica; Kelleher, Joseph; Gollob, Jared; Mainolfi, Nello; Weiss, Matt 分享 收藏
A STAT3 selective targeted protein degrader decreases the immunesuppressive tumor microenvironment and drives antitumor activity in preclinical models Csibi, Alfredo; Yang, Bin; Chutake, Yogesh; Yuan, Karen; Mayo, Michele; Campbell, Veronica; McDonald, Alice; Rusin, Scott; Sharma, Kirti; Kamadurai, Hari; Li, Henry; Sintchak, Mike; Zhu, Sean; Townson, Sharon; Slavin, Anthony; Rong, Haojing; Liu, Phillip; De Savi, Chris; Gollob, Jared; Walker, Duncan; Ji, Nan; Mainolfi, Nello 分享 收藏
A phase II, open-label, extension study of long-term patisiran treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis Coelho, Teresa; Adams, David; Conceicao, Isabel; Waddington-Cruz, Marcia; Schmidt, Hartmut H.; Buades, Juan; Campistol, Josep; Berk, John L.; Polydefkis, Michael; Wang, Jing Jing; Chen, Jihong; Sweetser, Marianne T.; Gollob, Jared; Suhr, Ole B. 分享 收藏
DISCOVERY: prevalence of transthyretin (TTR) mutations in a US-centric patient population suspected of having cardiac amyloidosis Akinboboye, Ola; Shah, Keyur; Warner, Alberta L.; Damy, Thibaud; Taylor, Herman A.; Gollob, Jared; Powell, Christine; Karsten, Verena; Vest, John; Maurer, Mathew S. 分享 收藏
Discovery of KYM-003, a potent and selective STAT3 degrader with antitumor activity in heme malignancies Csibi, Fred; Ji, Nan; Yang, Bin; Yuan, Karen; Mayo, Michele; Rong, Haojing; Rusin, Scott; Sharma, Kirti; Loh, Christine; Li, Henry; Townson, Sharon; Kamadurai, Hari; Chen, Jesse; Walker, Duncan; Gollob, Jared; Mainolfi, Nello 分享 收藏
KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition Kelleher, Joseph F.; Campbell, Veronica; Chen, Jesse; Gollob, Jared; Ji, Nan; Kamadurai, Hari; Klaus, Christine; Li, Henry; Loh, Christine; McDonald, Alice; Rong, Haojing; Rusin, Scott; Sharma, Kirti; Vigil, Dominico; Walker, Duncan; Weiss, Matt; Yuan, Karen; Zhang, Yi; Audoly, Laurent; Mainolfi, Nello 分享 收藏
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis: Analysis of the APOLLO Study Solomon, Scott D.; Adams, David; Kristen, Arnt; Grogan, Martha; Gonzalez-Duarte, Alejandra; Maurer, Mathew S.; Merlini, Giampaolo; Damy, Thibaud; Slama, Michel S.; Brannagan, Thomas H., III; Dispenzieri, Angela; Berk, John L.; Shah, Amil M.; Garg, Pushkal; Vaishnaw, Akshay; Karsten, Verena; Chen, Jihong; Gollob, Jared; Vest, John; Suhr, Ole 分享 收藏
NT-proBNP Levels in Patients with Hereditary Transthyretin-mediated Amyloidosis Treated in the Phase 3 APOLLO Study Based on Diuretic Use Grogan, Martha; Adams, David; Coelho, Teresa; Kristen, Arnt; Dispenzieri, Angela; Solomon, Scott; Gollob, Jared; Goyal, Sunita; Partisano, Angela M.; Chen, Jihong; Vest, John; Suhr, Ole B. 分享 收藏
Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis Patisiran，一种RNAi治疗药物，用于遗传性转甲状腺素蛋白淀粉样变性 Adams, D.; Gonzalez-Duarte, A.; O'Riordan, W. D.; Yang, C. -C.; Ueda, M.; Kristen, A. V.; Tournev, I.; Schmidt, H. H.; Coelho, T.; Berk, J. L.; Lin, K. -P.; Vita, G.; Attarian, S.; Plante-Bordeneuve, V.; Mezei, M. M.; Campistol, J. M.; Buades, J.; Brannagan, T. H., III; Kim, B. J.; Oh, J.; Parman, Y.; Sekijima, Y.; Hawkins, P. N.; Solomon, S. D.; Polydefkis, M.; Dyck, P. J.; Gandhi, P. J.; Goyal, S.; Chen, J.; Strahs, A. L.; Nochur, S. V.; Sweetser, M. T.; Garg, P. P.; Vaishnaw, A. K.; Gollob, J. A.; Suhr, O. B. 分享 收藏
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GaINAc-siRNA Conjugate Zimmermann, Tracy S.; Karsten, Verena; Chan, Amy; Chiesa, Joseph; Boyce, Malcolm; Bettencourt, Brian R.; Hutabarat, Renta; Nochur, Saraswathy; Vaishnaw, Akshay; Gollob, Jared 分享 收藏
Serial scanning with technetium pyrophosphate (99mTc-PYP) in advanced ATTR cardiac amyloidosis Castano, Adam; DeLuca, Albert; Weinberg, Richard; Pozniakoff, Ted; Blaner, William S.; Pirmohamed, Altaf; Bettencourt, Brian; Gollob, Jared; Karsten, Verena; Vest, John A.; Chiuzan, Codruta; Maurer, Mathew S.; Bokhari, Sabahat 分享 收藏
PATISIRAN PH 2 OPEN-LABEL EXTENSION STUDY IN FAMILIAL AMYLOIDOTIC POLYNEUROPATHY Schmidt, Hartmut; Adams, David; Coelho, Teresa; Conceicao, Isabel; Waddington-Cruz, Marcia; Buades, Juan; Campistol, Josep; Pouget, Jean; Gollob, Jared; Suhr, Ole 分享 收藏
BURDEN OF ILLNESS FOR PATIENTS WITH HEREDITARY ATTR AMYLOIDOSIS WITH POLYNEUROPATHY BEGINS WITH SYMPTOM ONSET AND INCREASES WITH DISEASE PROGRESSION Denoncourt, R. N.; Adams, D.; Gonzalez-Duarte, A.; O'Riordan, W.; Yang, C.; Yamashita, T.; Kristen, A.; Tournev, I; Schmidt, H.; Coelho, T.; Berk, J.; Lin, K.; Chen, J.; Gollob, J.; Suhr, O. 分享 收藏
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