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A phase 1 dose escalation study of a novel coupled CAR T cell therapy, GCC19CART, for patients with metastatic colorectal cancer Keenan, Bridget P.; Lieu, Christopher H.; Fakih, Marwan; Chen, Dongqi; Lu, Lucy; Rowinsky, Eric; Lu, Victor; Xiao, Lei; Venook, Alan P.; Schlechter, Benjamin 分享 收藏
Safety, pharmacokinetics, and pharmacodynamics in healthy Chinese volunteers treated with SC0062, a highly selective endothelin-A receptor antagonist Liu, Yun; Wang, Wei; Qian, Hongjie; Gui, Yuzhou; Wang, Yating; Song, Rong; Chen, Qian; Rowinsky, Eric; Wang, Sheng; Liang, Xiaoguang; Gu, Kaicun; Zhou, Bo; Zhang, Weiwei; Zhang, Liqin; Yu, Chen; Jia, Jingying 分享 收藏
A phase I/II clinical study of an oncolytic adenovirus expressing the immunostimulatory transgenes TMZ-CD40L and 4-1BBL in advanced solid malignancies Hahn, Amanda; Irenaeus, Sandra; Wenthe, Jessica; Eriksson, Emma; Schiza, Aglaia; Dahlstrand, Hanna; Olsson-Stromberg, Ulla; Krause, Johan; Sundin, Anders; Sandin, Linda; Jarblad, Justyna Leja; Liljefors, Maria Gustafsson; Rowinsky, Eric; Loskog, Angelica; Ullenhag, Gustav J. 分享 收藏
A CRUK phase I/IIA, first in human dose-escalation and expansion trial of HMBD-001 (an anti-HER-3 antibody) in patients with advanced HER3-positive solid tumours de Bono, J. S.; Lord, S.; Yap, C.; Rowinsky, E. K.; Gandhi, N. A.; Thakkar, D.; Ingram, P. J.; Padmanabhan, N.; Chandran, K.; Paschalis, A.; McGuigan, L.; Neal, P.; Paisley, D.; Walter, H. S.; Kelly, F.; Craigan, J.; Westwood, N. B.; Halbert, G.; Boyd-Kirkup, J. D.; Halford, S. E. R. 分享 收藏
Correlative analysis of pharmacokinetics and pharmacodynamics of RGX-104, a first-in-class Liver-X-Receptor (LXR) agonist, and clinical outcomes in patients with advanced solid tumors Mita, Monica; Mita, Alan; Hamilton, Erika; Falchook, Gerald S.; Postow, Michael; Chmielowski, Bartosz; Schilder, Russell J.; Strauss, James; Lim, Emerson; Pant, Shubham; Jain, Angela; Rixe, Oliver; Redman, Rebecca; Kim, Kevin B.; Dragovich, Tomislav; Harvey, R. Donald; Puzanov, Igor; Schneider, Nimisha; Deehan, Renee; Guennel, Tobi; Lin, Joe; Tavazoie, Sohail; Waltzman, Roger; Rowinsky, Eric; Szarek, Michael; Sridhar, Subhasree; Busby, Robert; Lebaka, Narayan; Andreu, Celia; Kurth, Isabel; Darst, David; Tavazoie, Masoud; Raza, Syed; Wasserman, Robert; Gonsalves, Foster C. 分享 收藏
Phase 1 study of the protein deubiquitinase inhibitor VLX1570 in patients with relapsed and/or refractory multiple myeloma Rowinsky, Eric K.; Paner, Agne; Berdeja, Jesus G.; Paba-Prada, Claudia; Venugopal, Parameswaran; Porkka, Kimmo; Gullbo, Joachim; Linder, Stig; Loskog, Angelica; Richardson, Paul G.; Landgren, Ola 分享 收藏
A phase 1 trial of RGX-104, a first-in-class immunotherapy targeting the liver-X nuclear hormone receptor (LXR), in patients with refractory malignancies Mita, Monica; Mita, Alain; Chmielowski, Bartosz; Postow, Michael; Hamilton, Erika; Pant, Shubham; Waltzman, Roger; Rowinsky, Eric; Szarek, Michael; Gonsalves, Foster; Kurth, Isabel; Andreu, Celia; Pollack, Ilana; Mucida, Daniel; Tanqueco, Raissa; Tavazoie, Sohail; Tavazoie, Masoud 分享 收藏
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Aberrant expression of CD123 (interleukin-3 receptor-α) on neoplastic mast cells Pardanani, A.; Lasho, T.; Chen, D.; Kimlinger, T. K.; Finke, C.; Zblewski, D.; Patnaik, M. M.; Reichard, K. K.; Rowinsky, E.; Hanson, C. A.; Brooks, C.; Tefferi, A. 分享 收藏
In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent Angelot-Delettre, Fanny; Roggy, Anne; Frankel, Arthur E.; Lamarthee, Baptiste; Seilles, Estelle; Biichle, Sabeha; Royer, Bernard; Deconinck, Eric; Rowinsky, Eric K.; Brooks, Christopher; Bardet, Valerie; Benet, Blandine; Bennani, Hind; Benseddik, Zehaira; Debliquis, Agathe; Lusina, Daniel; Roussel, Mikael; Solly, Francoise; Ticchioni, Michel; Saas, Philippe; Garnache-Ottou, Francine 分享 收藏
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Erlotinib 'dosing-to-rash': a phase II intrapatient dose escalation and pharmacologic study of erlotinib in previously treated advanced non-small cell lung cancer Mita, A. C.; Papadopoulos, K.; de Jonge, M. J. A.; Schwartz, G.; Verweij, J.; Mita, M. M.; Ricart, A.; Chu, Qs-C; Tolcher, A. W.; Wood, L.; McCarthy, S.; Hamilton, M.; Iwata, K.; Wacker, B.; Witt, K.; Rowinsky, E. K. 分享 收藏
A phase II randomized study of cetuximab and bevacizumab alone or in combination with gemcitabine as first-line therapy for metastatic pancreatic adenocarcinoma Ko, Andrew H.; Youssoufian, Hagop; Gurtler, Jayne; Dicke, Karel; Kayaleh, Omar; Lenz, Heinz-Josef; Keaton, Mark; Katz, Terry; Ballal, Shaila; Rowinsky, Eric K. 分享 收藏
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A let-7 microRNA-binding site polymorphism in 3′-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy KRAS基因3 ′-非翻译区let-7 microRNA结合位点多态性可预测西妥昔单抗单药治疗的转移性结直肠癌野生型KRAS患者的反应 Zhang, W.; Winder, T.; Ning, Y.; Pohl, A.; Yang, D.; Kahn, M.; Lurje, G.; LaBonte, M. J.; Wilson, P. M.; Gordon, M. A.; Hu-Lieskovan, S.; Mauro, D. J.; Langer, C.; Rowinsky, E. K.; Lenz, H. -J. 分享 收藏
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