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Novel Dual Glucagon and Glucagon-Like Peptide-1 Receptor Agonist LY3305677 Improves Glucose Control, Reduces Body Weight, and Increases Energy Expenditure in Mice Chen, Yanyun; Mezo, Adam; Coskun, Tamer; Song, Min; Roell, William C.; Bokvist, Krister B.; Moyers, Julie S.; Thomas, Melissa K.; Valenzuela, Francisco; Qu, Hongchang 分享 收藏
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Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes Khamis, Amna; Canouil, Mickael; Siddiq, Afshan; Crouch, Hutokshi; Falchi, Mario; von Bulow, Manon; Ehehalt, Florian; Marselli, Lorella; Distler, Marius; Richter, Daniela; Weitz, Juergen; Bokvist, Krister; Xenarios, Ioannis; Thorens, Bernard; Schulte, Anke M.; Ibberson, Mark; Bonnefond, Amelie; Marchetti, Piero; Solimena, Michele; Froguel, Philippe 分享 收藏
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LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept Coskun, Tamer; Sloop, Kyle W.; Loghin, Corina; Alsina-Fernandez, Jorge; Urva, Shweta; Bokvist, Krister B.; Cui, Xuewei; Briere, Daniel A.; Cabrera, Over; Roell, William C.; Kuchibhotla, Uma; Moyers, Julie S.; Benson, Charles T.; Gimeno, Ruth E.; D'Alessio, David A.; Haupt, Axel 分享 收藏
Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in hIAPP transgenic mice Templin, Andrew T.; Meier, Daniel T.; Willard, Joshua R.; Wolden-Hanson, Tami; Conway, Kelly; Lin, Yin-Guo; Gillespie, Patrick J.; Bokvist, Krister B.; Attardo, Giorgio; Kahn, Steven E.; Scheuner, Donalyn; Hull, Rebecca L. 分享 收藏
Episodic β-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice Tersey, Sarah A.; Levasseur, Esther M.; Syed, Farooq; Farb, Thomas B.; Orr, Kara S.; Nelson, Jennifer B.; Shaw, Janice L.; Bokvist, Krister; Mather, Kieren J.; Mirmira, Raghavendra G. 分享 收藏
Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes 来自器官供体和胰腺切除患者的IMIDIA生物库的系统生物学定义了2型糖尿病患者胰岛的新型转录组学特征 Solimena, Michele; Schulte, Anke M.; Marselli, Lorella; Ehehalt, Florian; Richter, Daniela; Kleeberg, Manuela; Mziaut, Hassan; Knoch, Klaus-Peter; Parnis, Julia; Bugliani, Marco; Siddiq, Afshan; Joerns, Anne; Burdet, Frederic; Liechti, Robin; Suleiman, Mara; Margerie, Daniel; Syed, Farooq; Distler, Marius; Gruetzmann, Robert; Petretto, Enrico; Moreno-Moral, Aida; Wegbrod, Carolin; Soenmez, Anke; Pfriem, Katja; Friedrich, Anne; Meinel, Joern; Wollheim, Claes B.; Baretton, Gustavo B.; Scharfmann, Raphael; Nogoceke, Everson; Bonifacio, Ezio; Sturm, Dorothee; Meyer-Puttlitz, Birgit; Boggi, Ugo; Saeger, Hans-Detlev; Filipponi, Franco; Lesche, Mathias; Meda, Paolo; Dahl, Andreas; Wigger, Leonore; Xenarios, Ioannis; Falchi, Mario; Thorens, Bernard; Weitz, Juergen; Bokvist, Krister; Lenzen, Sigurd; Rutter, Guy A.; Froguel, Philippe; von Buelow, Manon; Ibberson, Mark; Marchetti, Piero 分享 收藏
Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5 Farb, Thomas B.; Adeva, Marta; Beauchamp, Thomas J.; Cabrera, Over; Coates, David A.; Meredith, Tamika DeShea; Droz, Brian A.; Efanov, Alexander; Ficorilli, James V.; Gackenheimer, Susan L.; Martinez-Grau, Maria A.; Molero, Victoriano; Ruano, Gema; Statnick, Michael A.; Suter, Todd M.; Syed, Samreen K.; Toledo, Miguel A.; Willard, Francis S.; Zhou, Xin; Bokvist, Krister B.; Barrett, David G. 分享 收藏
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Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin Willard, Francis S.; Wootten, Denise; Showalter, Aaron D.; Savage, Emilia E.; Ficorilli, James; Farb, Thomas B.; Bokvist, Krister; Alsina-Fernandez, Jorge; Furness, Sebastian G. B.; Christopoulos, Arthur; Sexton, Patrick M.; Sloop, Kyle W. 分享 收藏
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Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells 磷脂酰肌醇4-激酶作为代谢传感器,调节胰腺 β 细胞分泌颗粒的启动 Olsen, HL; Hoy, M; Zhang, W; Bertorello, AM; Bokvist, K; Capito, K; Efanov, AM; Meister, B; Thams, P; Yang, SN; Rorsman, P; Berggren, PO; Gromada, J 分享 收藏