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Early-Stage IM Treatment with the Host-Derived Immunostimulant CPDI-02 Increases Curative Protection of Healthy Outbred Mice Against Subcutaneous Infection with Community-Acquired Methicillin-Resistant Staphylococcus aureus USA300 Stewart, Jason P.; Sandall, Caleb M.; Parriott, Jacob E.; Curran, Stephen M.; Mcculloh, Russell J.; Ronning, Donald R.; Phillips, Joy A.; Schroeder, Robin; Neel, Christy; Lechtenberg, Kelly F.; Cohen, Samuel M.; Alnouti, Yazen; Daria, Sohel; Smith, D. David; Vetro, Joseph A. 分享 收藏
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Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice Alrehaili, Bandar D.; Lee, Mikang; Takahashi, Shogo; Novak, Robert; Rimal, Bipin; Boehme, Shannon; Trammell, Samuel A. J.; Grevengoed, Trisha J.; Kumar, Devendra; Alnouti, Yazen; Chiti, Katya; Wang, Xinwen; Patterson, Andrew D.; Chiang, John Y. L.; Gonzalez, Frank J.; Lee, Yoon-Kwang 分享 收藏
Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation Deodhar, Suyash; Sillman, Brady; Bade, Aditya N.; Avedissian, Sean N.; Podany, Anthony T.; McMillan, JoEllyn M.; Gautam, Nagsen; Hanson, Brandon; Shetty, Bhagya L. Dyavar; Szlachetka, Adam; Johnston, Morgan; Thurman, Michellie; Munt, Daniel J.; Dash, Alekha K.; Markovic, Milica; Dahan, Arik; Alnouti, Yazen; Yazdi, Alborz; Kevadiya, Bhavesh D.; Byrareddy, Siddappa N.; Cohen, Samuel M.; Edagwa, Benson; Gendelman, Howard E. 分享 收藏
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Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth Napoleon, John Victor; Sagar, Satish; Kubica, Sydney P.; Boghean, Lidia; Kour, Smit; King, Hannah M.; Sonawane, Yogesh A.; Crawford, Ayrianne J.; Gautam, Nagsen; Kizhake, Smitha; Bialk, Pawel A.; Kmiec, Eric; Mallareddy, Jayapal Reddy; Patil, Prathamesh P.; Rana, Sandeep; Singh, Sarbjit; Prahlad, Janani; Grandgenett, Paul M.; Borgstahl, Gloria E. O.; Ghosal, Gargi; Alnouti, Yazen; Hollingsworth, Michael A.; Radhakrishnan, Prakash; Natarajan, Amarnath 分享 收藏
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Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC Ye, Zhen; Abdelmoaty, Mai Mohamed; Curran, Stephen M.; Dyavar, Shetty Ravi; Kumar, Devendra; Alnouti, Yazen; Coulter, Don W.; Podany, Anthony T.; Singh, Rakesh K.; Vetro, Joseph A. 分享 收藏
Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles Cobb, Denise A.; Smith, Nathan; Deodhar, Suyash; Bade, Aditya N.; Gautam, Nagsen; Shetty, Bhagya Laxmi Dyavar; McMillan, JoEllyn; Alnouti, Yazen; Cohen, Samuel M.; Gendelman, Howard E.; Edagwa, Benson 分享 收藏
Intramuscular and subcutaneous administration of antiretroviral drugs, compared with oral, enhances delivery to lymphoid tissues in BALB/c mice Dyavar, Shetty Ravi; Kumar, Sushil; Gautam, Nagsen; Podany, Anthony T.; Winchester, Lee C.; Weinhold, Jonathan A.; Mykris, Timothy M.; Nallasamy, Palanisamy; Alnouti, Yazen; Fletcher, Courtney, V 分享 收藏
Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir Gautam, Nagsen; McMillan, JoEllyn M.; Kumar, Devendra; Bade, Aditya N.; Pan, Qiaoyu; Kulkarni, Tanmay A.; Li, Wenkuan; Sillman, Brady; Smith, Nathan A.; Shetty, Bhagya L. Dyavar; Szlachetka, Adam; Edagwa, Benson J.; Gendelman, Howard E.; Alnouti, Yazen 分享 收藏
The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice Chu, Huikuan; Jiang, Lu; Gao, Bei; Gautam, Nagsen; Alamoudi, Jawaher A.; Lang, Sonja; Wang, Yanhan; Duan, Yi; Alnouti, Yazen; Cable, Edward E.; Schnabl, Bernd 分享 收藏
Discovery, synthesis and biological characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators Sharma, Swagat; Lesiak, Lauren; Aretz, Christopher D.; Du, Yu; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; Dhuria, Nikilesh, V; Chhonker, Yashpal S.; Weaver, C. David; Hopkins, Corey R. 分享 收藏
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KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo Burkovetskaya, Maria E.; Liu, Qiaoling; Vadukoot, Anish K.; Gautam, Nagsen; Alnouti, Yazen; Kumar, Sushil; Miczek, Klaus; Buch, Shilpa; Hopkins, Corey R.; Guo, Minglei 分享 收藏
A year-long extended release nanoformulated cabotegravir prodrug Kulkarni, Tanmay A.; Bade, Aditya N.; Sillman, Brady; Shetty, Bhagya Laxmi Dyavar; Wojtkiewicz, Melinda S.; Gautam, Nagsen; Hilaire, James R.; Sravanam, Sruthi; Szlachetka, Adam; Lamberty, Benjamin G.; Morsey, Brenda M.; Fox, Howard S.; Alnouti, Yazen; McMillan, JoEllyn M.; Mosley, R. Lee; Meza, Jane; Domanico, Paul L.; Yue, Tai-Yuen; Moore, Gary; Edagwa, Benson J.; Gendelman, Howard E. 分享 收藏
Synthesis and SAR Studies of 1H-Pyrrolo[2,3-b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors Vadukoot, Anish K.; Sharma, Swagat; Aretz, Christopher D.; Kumar, Sushil; Gautam, Nagsen; Alnouti, Yazen; Aldrich, Amy L.; Heim, Cortney E.; Kielian, Tammy; Hopkins, Corey R. 分享 收藏
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