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P

P.L. Shaffer

Johnson & Johnson
H指数:21
被引数:2,622

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Optimization of Covalent 6-Cyanoquinazoline KRASG12C Inhibitors for the Treatment of Solid Tumors

共价6-氰基喹唑啉KRASG12C抑制剂的优化，用于实体瘤的治疗

Journal of Medicinal Chemistry
IF6.8
2026-04-010
PRE
Jesse P. Waldo; Paul J. Krawczuk; Christopher B. Kelly; Christopher G. Callas; Justin S. Cisar; Wendy Eccles; Carlos A. Guerrero; Michael D. Hack; William M. Jones; Colleen E. Keohane; Lian-Sheng Li; Sanath Meegalla; Rosaura Padilla-Salinas; Robert J. Rosano; Kirk W. Shimkin; Yvan R. F. Simonnet; Doree Sitkoff; Anasheh Sookezian; Michael P. Winters; Tammy L. Bush; Sheldon T. Cheung; Amanda M. Del Rosario; Rasmus Hansen; Matthew R. Janes; Haleema Janjua; Faraz Kazmi; Robert Kirkpatrick; David La; Ryan Lenhart; Matthew V. Lorenzi; Yi Liu; Natalie Mesens; Cynthia M. Milligan; Heather Murrey; Ulf Peters; Pingda Ren; Mark Richter; Michele Rizzolio; Swetha Rao; Paul Shaffer; Christopher F. Stratton; Lawrence M. Szewczuk; Jenny Wen; Victoria Wong; Carol Yanovich; Sylvie Laquerre; James P. Edwards; Kristi A. Leonard
Author Correction: Folding-mediated secretion of pure bispecific antibodies

作者更正：折叠介导的纯双特异性抗体分泌

Nature Biotechnology
IF41.7
2025-10-280
OAAI
Cholpon Tilegenova; Tun Liu; Qian Zhao; Mahati Are; Yu Zhao; Woo Suk Choi; Anusarka Bhaumik; Ruth Steele; Nicholas A. Manieri; Bengi Turegun; Alex Ni; Rosa M. F. Cardoso; Paul Shaffer; Desmond Clark; Robin Ernst; Wenyu Li; Tracy Taylor; Suresh Kumar Swaminathan; Bhargavi Ramaraju; Kevin Liaw; Steven A. Jacobs; Sujata Sharma; Wan Cheung Cheung; Adam Zwolak
Folding-mediated secretion of pure bispecific antibodies

折叠介导的纯双特异性抗体分泌

Nature Biotechnology
IF41.7
2025-10-070
PRE
Cholpon Tilegenova; Tun Liu; Qian Zhao; Mahati Are; Yu Zhao; Woo Suk Choi; Anusarka Bhaumik; Ruth Steele; Nicholas A. Manieri; Bengi Turegun; Alex Ni; Rosa M. F. Cardoso; Paul Shaffer; Desmond Clark; Robin Ernst; Wenyu Li; Tracy Taylor; Suresh Kumar Swaminathan; Bhargavi Ramaraju; Kevin Liaw; Steven A. Jacobs; Sujata Sharma; Wan Cheung Cheung; Adam Zwolak
Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration

GluN2A负性别构调节剂的分子设计、合成与表征及其在活体内的应用研究

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-02-172
PRE
Bischoff, Francois P.; Van Brandt, Sven; Viellevoye, Marcel; De Cleyn, Michel; Surkyn, Michel; Carbajo, Rodrigo J.; Blanco, Maria Dominguez; Wroblowski, Berthold; Karpowich, Nathan K.; Steele, Ruth A.; Schalk-Hihi, Celine; Miller, Robyn; Duda, David; Shaffer, Paul; Ballentine, Scott; Simavorian, Sirak; Lord, Brian; Neff, Robert A.; Bonaventure, Pascal; Gijsen, Harrie J. M.
Spiro-Azetidine Oxindoles as Long-Acting Injectables for Pre-Exposure Prophylaxis against Respiratory Syncytial Virus Infections
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-06-270
PRE
Kesteleyn, Bart; Herschke, Florence; Darville, Nicolas; Stoops, Bart; Jacobs, Tom; Jacoby, Edgar; Shaffer, Paul; Lammens, Lieve; Van Rompaey, Dries; Matcha, Kiran; Lamenca, Carolina Martinez; Coesemans, Erwin; Hache, Geerwin; Pieters, Serge; Lecomte, Morgan; Hu, Lili; Demin, Samuel; Milligan, Cynthia; Abeywickrema, Pravien; De Bruyn, Suzanne; Van Den Berg, Joke; Ysebaert, Nina; De Zwart, Loeckie; Najera, Isabel; Rigaux, Peter; Roymans, Dirk; Jonckers, Tim H. M.
Identification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2023-12-267
OAAI
Babbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-07-2111
PRE
Xu, Guozhang; Liu, Zhijie; Wang, Xinkang; Lu, Tianbao; DesJarlais, Renee L.; Thieu, Tho; Zhang, Jing; Devine, Zheng Huang; Du, Fuyong; Li, Qiu; Milligan, Cynthia M.; Shaffer, Paul; Cedervall, Peder E.; Spurlino, John C.; Stratton, Christopher F.; Pietrak, Beth; Szewczuk, Lawrence M.; Wong, Victoria; Steele, Ruth A.; Bruinzeel, Wouter; Chintala, Madhu; Silva, Jose; Gaul, Michael D.; Macielag, Mark J.; Nargund, Ravi
Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-11-1614
PREAI
Martinez-Viturro, Carlos M.; Trabanco, Andres A.; Royes, Jordi; Fernandez, Elena; Tresadern, Gary; Vega, Juan A.; Del Cerro, Alcira; Delgado, Francisca; Garcia Molina, Aranzazu; Tovar, Fulgencio; Shaffer, Paul; Ebneth, Andreas; Bretteville, Alexis; Mertens, Liesbeth; Somers, Marijke; Alonso, Jose M.; Bartolome-Nebreda, Jose M.
The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2016-12-2134
PREAI
Bregman, Howard; Simard, Jeffrey R.; Andrews, Kristin L.; Ayube, Shawn; Chen, Hao; Gunaydin, Hakan; Guzman-Perez, Angel; Hu, Jiali; Huang, Liyue; Huang, Xin; Krolikowski, Paul H.; Lehto, Sonya G.; Lewis, Richard T.; Michelsen, Klaus; Pegman, Pamela; Plant, Matthew H.; Shaffer, Paul L.; Teffera, Yohannes; Yi, Shuyan; Zhang, Maosheng; Gingras, Jacinthe; DiMauro, Erin F.
Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK)
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2015-01-1478
PREAI
Smith, Adrian L.; Andrews, Kristin L.; Beckmann, Holger; Bellon, Steven F.; Beltran, Pedro J.; Booker, Shon; Chen, Hao; Chung, Young-Ah; D'Angelo, Noel D.; Dao, Jennifer; Dellamaggiore, Kenneth R.; Jaeckel, Peter; Kendall, Richard; Labitzke, Katja; Long, Alexander M.; Materna-Reichelt, Silvia; Mitchell, Petia; Norman, Mark H.; Powers, David; Rose, Mark; Shaffer, Paul L.; Wu, Michelle M.; Lipford, J. Russell
Discovery of AM-7209, a Potent and Selective 4-Amidobenzoic Acid Inhibitor of the MDM2-p53 Interaction
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2014-12-0463
PREAI
Rew, Yosup; Sun, Daqing; Yan, Xuelei; Beck, Hilary P.; Canon, Jude; Chen, Ada; Duquette, Jason; Eksterowicz, John; Fox, Brian M.; Fu, Jiasheng; Gonzalez, Ana Z.; Houze, Jonathan; Huang, Xin; Jiang, Min; Jin, Lixia; Li, Yihong; Li, Zhihong; Ling, Yun; Lo, Mei-Chu; Long, Alexander M.; McGee, Lawrence R.; McIntosh, Joel; Oliner, Jonathan D.; Osgood, Tao; Saiki, Anne Y.; Shaffer, Paul; Wang, Yu Chung; Wortman, Sarah; Yakowec, Peter; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Medina, Julio C.; Olson, Steven H.
Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2014-07-0924
OAAI
Yu, Ming; Wang, Yingcai; Zhu, Jiang; Bartberger, Michael D.; Canon, Jude; Chen, Ada; Chow, David; Eksterowicz, John; Fox, Brian; Fu, Jiasheng; Gribble, Michael; Huang, Xin; Li, Zhihong; Liu, Jiwen (Jim); Lo, Mei-chu; McMinn, Dustin; Oliner, Jonathan D.; Osgood, Tao; Rew, Yosup; Saiki, Anne Y.; Shaffer, Paul; Yan, Xuelei; Ye, Qiuping; Yu, Dongyin; Zhao, Xiaoning; Zhou, Jing; Olson, Steven H.; Medina, Julio C.; Sun, Daqing

研究方向

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X
Xiaoning Zhao
H 指数:51论文数:259被引数:1.0万
A
Alexander Long
H 指数:33论文数:151被引数:5,161
A
Anne Y. Saiki
H 指数:21论文数:57被引数:4,938
X
Xin Huang
H 指数:16论文数:24被引数:1,509
J
Jing Zhou
H 指数:30论文数:91被引数:3,262
Y
Yosup Rew
H 指数:24论文数:55被引数:1,826
T
Tao Osgood
H 指数:16论文数:75被引数:3,780
D
Daqing Sun
H 指数:24论文数:111被引数:2,682
M
Mei-Chu Lo
H 指数:20论文数:39被引数:2,330
J
Jude Canon
H 指数:31论文数:188被引数:7,580