David Owen - Publications, H-index & Citations

David Owen

science & technology facilities council (stfc)

25H指数

348论文数

2.7K被引数

收录论文 24

发表时间

TRPXv2.0: superfast, parallel compression of diffraction patterns and images, with native Python and HDF5 support TRPXv2.0：超快速、并行压缩衍射图案和图像，支持原生Python和HDF5

Ultramicroscopy

IF2

2025-12-01

OAAI

Matinyan, S.; Filipcik, P.; Waterman, D. G.; Owen, C. D.; Abrahams, J. P.

Cryo-tomography and 3D Electron Diffraction Reveal the Polar Habit and Chiral Structure of the Malaria Pigment Crystal Hemozoin

ACS CENTRAL SCIENCE

IF10.4

2024-07-04

OAAI

Klar, Paul Benjamin; Waterman, David Geoffrey; Gruene, Tim; Mullick, Debakshi; Song, Yun; Gilchrist, James Boris; Owen, C. David; Wen, Wen; Biran, Idan; Houben, Lothar; Regev-Rudzki, Neta; Dzikowski, Ron; Marom, Noa; Palatinus, Lukas; Zhang, Peijun; Leiserowitz, Leslie; Elbaum, Michael

Exploring the sequence-function space of microbial fucosidases

COMMUNICATIONS CHEMISTRY

IF6.2

2024-06-18

OAAI

Gascuena, Ana Martinez; Wu, Haiyang; Wang, Rui; Owen, C. David; Hernando, Pedro J.; Monaco, Serena; Penner, Matthew; Xing, Ke; Le Gall, Gwenaelle; Gardner, Richard; Ndeh, Didier; Urbanowicz, Paulina A.; Spencer, Daniel I. R.; Walsh, Martin; Angulo, Jesus; Juge, Nathalie

Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

IF3.8

2024-03-06

OAAI

Miura, Takashi; Malla, Tika R.; Brewitz, Lennart; Tumber, Anthony; Salah, Eidarus; Lee, Kang Ju; Terasaka, Naohiro; Owen, C. David; Strain-Damerell, Claire; Lukacik, Petra; Walsh, Martin A.; Kawamura, Akane; Schofield, Christopher J.; Katoh, Takayuki; Suga, Hiroaki

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths

COMMUNICATIONS CHEMISTRY

IF6.2

2023-10-12

OAAI

El Omari, Kamel; Duman, Ramona; Mykhaylyk, Vitaliy; Orr, Christian M.; Latimer-Smith, Merlyn; Winter, Graeme; Grama, Vinay; Qu, Feng; Bountra, Kiran; Kwong, Hok Sau; Romano, Maria; Reis, Rosana I.; Vogeley, Lutz; Vecchia, Luca; Owen, C. David; Wittmann, Sina; Renner, Max; Senda, Miki; Matsugaki, Naohiro; Kawano, Yoshiaki; Bowden, Thomas A.; Moraes, Isabel; Grimes, Jonathan M.; Mancini, Erika J.; Walsh, Martin A.; Guzzo, Cristiane R.; Owens, Raymond J.; Jones, E. Yvonne; Brown, David G.; Stuart, Dave I.; Beis, Konstantinos; Wagner, Armin

Accelerating drug target inhibitor discovery with a deep generative foundation model

SCIENCE ADVANCES

IF12.5

2023-06-23

OAAI

Chenthamarakshan, Vijil; Hoffman, Samuel C.; Owen, C. David; Lukacik, Petra; Strain-Damerell, Claire; Fearon, Daren; Malla, Tika R.; Tumber, Anthony; Schofield, Christopher J.; Duyvesteyn, Helen M. E.; Dejnirattisai, Wanwisa; Carrique, Loic; Walter, Thomas S.; Screaton, Gavin R.; Matviiuk, Tetiana; Mojsilovic, Aleksandra; Crain, Jason; Walsh, Martin A.; Stuart, David I.; Das, Payel

In vitro selection of macrocyclic peptide inhibitors containing cyclic ?2,4-amino acids targeting the SARS-CoV-2 main protease

NATURE CHEMISTRY

IF20.2

2023-05-22

OAAI

Miura, Takashi; Malla, Tika R. R.; Owen, C. David; Tumber, Anthony; Brewitz, Lennart; McDonough, Michael A. A.; Salah, Eidarus; Terasaka, Naohiro; Katoh, Takayuki; Lukacik, Petra; Strain-Damerell, Claire; Mikolajek, Halina; Walsh, Martin A. A.; Kawamura, Akane; Schofield, Christopher J. J.; Suga, Hiroaki

Structure and function of microbial ?-L-fucosidases: a mini review

ESSAYS IN BIOCHEMISTRY

IF5.7

2023-04-18

OAAI

Wu, Haiyang; Owen, David; Juge, Nathalie

AI-Driven Discovery of SARS-CoV-2 Main Protease Fragment-like Inhibitors with Antiviral Activity In Vitro

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2023-04-14

PREAI

Saramago, Luiz Carlos; Santana, Marcos V.; Gomes, Barbara Figueira; Dantas, Rafael Ferreira; Senger, Mario R.; Borges, Pedro Henrique Oliveira; Ferreira, Vivian Neuza dos Santos; Rosa, Alice dos Santos; Tucci, Amanda Resende; Miranda, Milene Dias; Lukacik, Petra; Strain-Damerell, Claire; Owen, C. David; Walsh, Martin Austin; Ferreira, Sabrina Baptista; Silva-Junior, Floriano Paes

An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

NATURE COMMUNICATIONS

IF15.7

2023-03-20

OAAI

Noske, Gabriela Dias; Song, Yun; Fernandes, Rafaela Sachetto; Chalk, Rod; Elmassoudi, Haitem; Koekemoer, Lizbe; Owen, C. David J.; El-Baba, Tarick V.; Robinson, Carol; Oliva, Glaucius; Godoy, Andre Schutzer

Biochemical and structural basis of sialic acid utilization by gut microbes (vol 299, 104610, 2023)

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-03-01

OAAI

Bell, Andrew; Severi, Emmanuele; Owen, C. David; Latousakis, Dimitrios; Juge, Nathalie

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-02-09

OAAI

Brewitz, Lennart; Dumjahn, Leo; Zhao, Yilin; Owen, C. David; Laidlaw, Stephen M.; Malla, Tika R.; Nguyen, Dung; Lukacik, Petra; Salah, Eidarus; Crawshaw, Adam D.; Warren, Anna J.; Trincao, Jose; Strain-Damerell, Claire; Carroll, Miles W.; Walsh, Martin A.; Schofield, Christopher J.

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-05-12

OAAI

Malla, Tika R.; Brewitz, Lennart; Muntean, Dorian-Gabriel; Aslam, Hiba; Owen, C. David; Salah, Eidarus; Tumber, Anthony; Lukacik, Petra; Strain-Damerell, Claire; Mikolajek, Halina; Walsh, Martin A.; Schofield, Christopher J.

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

CELL CHEMICAL BIOLOGY

IF7.2

2021-12-01

OAAI

Zaidman, Daniel; Gehrtz, Paul; Filep, Mihajlo; Fearon, Daren; Gabizon, Ronen; Douangamath, Alice; Prilusky, Jaime; Duberstein, Shirly; Cohen, Galit; Owen, C. David; Resnick, Efrat; Strain-Damerell, Claire; Lukacik, Petra; Barr, Haim; Walsh, Martin A.; von Delft, Frank; London, Nir

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19 (vol 11, 13208, 2021)

SCIENTIFIC REPORTS

IF3.9

2021-09-28

OAAI

Redhead, Martin A.; Owen, C. David; Brewitz, Lennart; Collette, Amelia H.; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W.; Collins, Patrick M.; Schafer, Philipp; Swindells, Mark; Radoux, Chris J.; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R.; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Nguyen, Tu-Trinh; Hull, Mitchell; Tumber, Anthony; Hallett, David J.; Schofield, Christopher J.; Stuart, David I.; Hopkins, Andrew L.; Walsh, Martin A.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

SCIENTIFIC REPORTS

IF3.9

2021-06-24

OAAI

Redhead, Martin A.; Owen, C. David; Brewitz, Lennart; Collette, Amelia H.; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W.; Collins, Patrick M.; Schaefer, Philipp; Swindells, Mark; Radoux, Chris J.; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R.; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Tu-Trinh Nguyen; Hull, Mitchell; Tumber, Anthony; Hallett, David J.; Schofield, Christopher J.; Stuart, David I.; Hopkins, Andrew L.; Walsh, Martin A.

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

CHEMICAL COMMUNICATIONS

IF4.2

2021-01-01

OAAI

Malla, Tika R.; Tumber, Anthony; John, Tobias; Brewitz, Lennart; Strain-Damerell, Claire; Owen, C. David; Lukacik, Petra; Chan, H. T. Henry; Maheswaran, Pratheesh; Salah, Eidarus; Duarte, Fernanda; Yang, Haitao; Rao, Zihe; Walsh, Martin A.; Schofield, Christopher J.

Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding

CHEMICAL SCIENCE

IF7.4

2021-01-01

OAAI

Chan, H. T. Henry; Moesser, Marc A.; Walters, Rebecca K.; Malla, Tika R.; Twidale, Rebecca M.; John, Tobias; Deeks, Helen M.; Johnston-Wood, Tristan; Mikhailov, Victor; Sessions, Richard B.; Dawson, William; Salah, Eidarus; Lukacik, Petra; Strain-Damerell, Claire; Owen, C. David; Nakajima, Takahito; Swiderek, Katarzyna; Lodola, Alessio; Moliner, Vicent; Glowacki, David R.; Spencer, James; Walsh, Martin A.; Schofield, Christopher J.; Genovese, Luigi; Shoemark, Deborah K.; Mulholland, Adrian J.; Duarte, Fernanda; Morris, Garrett M.

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

NATURE COMMUNICATIONS

IF15.7

2020-10-07

223

OAAI

Douangamath, Alice; Fearon, Daren; Gehrtz, Paul; Krojer, Tobias; Lukacik, Petra; Owen, C. David; Resnick, Efrat; Strain-Damerell, Claire; Aimon, Anthony; Abranyi-Balogh, Peter; Brandao-Neto, Jose; Carbery, Anna; Davison, Gemma; Dias, Alexandre; Downes, Thomas D.; Dunnett, Louise; Fairhead, Michael; Firth, James D.; Jones, S. Paul; Keeley, Aaron; Keserue, Gyoergy M.; Klein, Hanna F.; Martin, Mathew P.; Noble, Martin E. M.; O'Brien, Peter; Powell, Ailsa; Reddi, Rambabu N.; Skyner, Rachael; Snee, Matthew; Waring, Michael J.; Wild, Conor; London, Nir; von Delft, Frank; Walsh, Martin A.

Fucosidases from the human gut symbiont Ruminococcus gnavus

CELLULAR AND MOLECULAR LIFE SCIENCES

IF6.2

2020-04-24

OAAI

Wu, Haiyang; Rebello, Osmond; Crost, Emmanuelle H.; Owen, C. David; Walpole, Samuel; Bennati-Granier, Chloe; Ndeh, Didier; Monaco, Serena; Hicks, Thomas; Colvile, Anna; Urbanowicz, Paulina A.; Walsh, Martin A.; Angulo, Jesus; Spencer, Daniel I. R.; Juge, Nathalie

研究方向