Lawrence J. Lesko - Publications, H-index & Citations

Lawrence J. Lesko

University of Florida

61H指数

253论文数

1.1W被引数

收录论文 64

发表时间

History and Evolution of Innovations in Clinical Pharmacology 临床药理学创新的历史与演变

Clinical Pharmacology & Therapeutics

IF5.5

2025-09-24

PREAI

Lawrence J. Lesko; Piet H. van der Graaf

Reflections on Model-Informed Drug Development

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2024-07-16

PREAI

Lesko, Lawrence J.; van der Graaf, Piet H.

Exploring the impact of CYP2D6 and UGT2B7 gene-drug interactions, and CYP-mediated DDI on oxycodone and oxymorphone pharmacokinetics using physiologically-based pharmacokinetic modeling and simulation

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2024-03-01

OAAI

Klose, Marian; Cristofoletti, Rodrigo; Silva, Carolina de Miranda; Mangal, Naveen; Turgeon, Jacques; Michaud, Veronique; Lesko, Lawrence J.; Schmidt, Stephan

Identification of Novel and Early Biomarkers for Cisplatin-induced Nephrotoxicity and the Nephroprotective Role of Cimetidine using a Pharmacometabolomic-based Approach Coupled with In Vitro Toxicodynamic Modeling and Simulation

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2024-01-01

OAAI

Mody, Hardik; Nair, Sreenath; Rump, Adrian; Vaidya, Tanaya R.; Garrett, Timothy J.; Lesko, Lawrence; Ait-Oudhia, Sihem

Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin

CELLS

IF5.2

2022-12-23

OAAI

Mody, Hardik; Vaidya, Tanaya R.; Lesko, Lawrence J.; Ait-Oudhia, Sihem

Application of a patient-centered reverse translational systems-based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2022-03-05

OAAI

Kim, Sarah; Lahu, Gezim; Vakilynejad, Majid; Soldatos, Theodoros G.; Jackson, David B.; Lesko, Lawrence J.; Trame, Mirjam N.

Advancing drug safety science by integrating molecular knowledge with post-marketing adverse event reports

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2022-02-20

OAAI

Soldatos, Theodoros G.; Kim, Sarah; Schmidt, Stephan; Lesko, Lawrence J.; Jackson, David B.

A case study of a patient-centered reverse translational systems-based approach to understand adverse event profiles in drug development

CTS-CLINICAL AND TRANSLATIONAL SCIENCE

IF2.8

2022-01-11

OAAI

Kim, Sarah; Lahu, Gezim; Vakilynejad, Majid; Soldatos, Theodoros G.; Jackson, David B.; Lesko, Lawrence J.; Trame, Mirjam N.

Perspective on model-informed drug development

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-08-17

OAAI

Lesko, Lawrence J.

Physiologically-based pharmacokinetics modeling to investigate formulation factors influencing the generic substitution of dabigatran etexilate

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2021-02-10

OAAI

Farhan, Nashid; Cristofoletti, Rodrigo; Basu, Sumit; Kim, Sarah; Lingineni, Karthik; Jiang, Sibo; Brown, Joshua D.; Fang, Lanyan (Lucy); Lesko, Lawrence J.; Schmidt, Stephan

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021

IF0

2021-01-06

101

OAAI

Darwich, Adam S.; Polasek, Thomas M.; Aronson, Jeffrey K.; Ogungbenro, Kayode; Wright, Daniel F. B.; Achour, Brahim; Reny, Jean-Luc; Daali, Youssef; Eiermann, Birgit; Cook, Jack; Lesko, Lawrence; McLachlan, Andrew J.; Rostami-Hodjegan, Amin

FDALabel for drug repurposing studies and beyond

NATURE BIOTECHNOLOGY

IF41.7

2020-11-24

OAAI

Fang, Hong; Harris, Stephen; Liu, Zhichao; Thakkar, Shraddha; Yang, Junshuang; Ingle, Taylor; Xu, Joshua; Lesko, Lawrence; Rosario, Lilliam; Tong, Weida

Semi-mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2020-06-18

OAAI

Venkatasubramanian, Raja; Collins, Teresa A.; Lesko, Lawrence J.; Mettetal, Jerome T.; Trame, Mirjam N.

Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine

DRUG DISCOVERY TODAY

IF7.5

2020-05-01

OAAI

Mehta, Darshan; Uber, Ryley; Ingle, Taylor; Li, Catherine; Liu, Zhichao; Thakkar, Shraddha; Ning, Baitang; Wu, Leihong; Yang, Junshuang; Harris, Steve; Zhou, Guangxu; Xu, Joshua; Tong, Weida; Lesko, Lawrence; Fang, Hong

Establishing a Multidisciplinary Framework to Study Drug-Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-10-23

OAAI

Lesko, Lawrence J.; Vozmediano, Valvanera; Brown, Joshua D.; Winterstein, Almut; Zhao, Ping; Lippert, Jorg; Hoechel, Joachim; Chaturvedula, Ayyappa; White, Annesha; Schmidt, Stephan

Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-10-16

OAAI

Keizer, Ron J.; ter Heine, Rob; Frymoyer, Adam; Lesko, Lawrence J.; Mangat, Ranvir; Goswami, Srijib

Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products

JOURNAL OF PHARMACEUTICAL SCIENCES

IF3.8

2018-10-01

PREAI

Cristofoletti, Rodrigo; Rowland, Malcolm; Lesko, Lawrence J.; Blume, Henning; Rostami-Hodjegan, Amin; Dressman, Jennifer B.

A Semi-Mechanistic Population Pharmacokinetic Model of Nusinersen: An Antisense Oligonucleotide for the Treatment of Spinal Muscular Atrophy

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY

IF3

2018-08-16

OAAI

Biliouris, Konstantinos; Gaitonde, Puneet; Yin, Wei; Norris, Daniel A.; Wang, Yanfeng; Henry, Scott; Fey, Robert; Nestorov, Ivan; Schmidt, Stephan; Rogge, Mark; Lesko, Lawrence J.; Trame, Mirjam N.

Efficacy From Strange Sources

CLINICAL PHARMACOLOGY & THERAPEUTICS

IF5.5

2017-12-01

PREAI

Lesko, Lawrence J.

The Creating an Optimal Warfarin Nomogram (CROWN) Study

THROMBOSIS AND HAEMOSTASIS

IF4.3

2017-11-29

OAAI

Perlstein, Todd S.; Goldhaber, Samuel Z.; Nelson, Kerrie; Joshi, Victoria; Morgan, T. Vance; Lesko, Lawrence J.; Lee, Joo-Yeon; Gobburu, Jogarao; Schoenfeld, David; Kucherlapati, Raju; Freeman, Mason W.; Creager, Mark A.

研究方向