未登录Selective Targeting of Cyclin E1 Using Molecular Glue Degraders in CCNE1 Amplified Solid Malignancies
Ilic-Widlund, N.; Tahaney, W.; Liu, Y.; Gkountela, S.; Quan, C.; Lucas, X.; Emil, N.; Diesslin, A.; King, C.; Dubois, A.; Osmont, A.; Zlotosch, M.; Bianda, C.; Alers, J.; Demarco, B.; Warmuth, M.; Townson, S.; Fasching, B.; Ranieri, B.; Tiedt, R. .png)
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收藏MRT-6160, A VAV1-DIRECTED MOLECULAR GLUE DEGRADER, REDUCES JOINT INFLAMMATION, CYTOKINE PRODUCTION, AND AUTOANTIBODY LEVELS IN A COLLAGEN-INDUCED ARTHRITIS DISEASE MODELMRT-6160，一种VAV1定向分子胶降解剂，可降低胶原诱导性关节炎疾病模型中的关节炎症、细胞因子产生和自身抗体水平。Cartwright, A.; Desai, F.; Vora, S.; Gyger, L.; Roditi, L.; Nguyen, S.; Trouilloud, A.; Lam, D.; Trenh, P.; Lucas, X.; Zlotosch, M.; Liardo, E.; Wible, D.; Oleinikovas, V.; Lamberto, I.; Demarco, B.; King, C.; Bonenfant, D.; Krishnan, E.; De Beukelaer, S.; Townson, S.; Wallace, O.; Janku, F.; Mcallister, L.; Paterson, A.; Peluso, M. 分享 收藏 分享 收藏 Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial InfectionsHawryluk, Natalie; Robinson, Dale; Shen, Yixing; Kyne, Graham; Bedore, Matthew; Menon, Sanjay; Canan, Stacie; von Geldern, Thomas; Townson, Simon; Gokool, Suzanne; Ehrens, Alexandra; Koschel, Marianne; Lhermitte-Vallarino, Nathaly; Martin, Coralie; Hoerauf, Achim; Hernandez, Geraldine; Dalvie, Deepak; Specht, Sabine; Hubner, Marc Peter; Scandale, Ivan 分享 收藏 Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimizationHawryluk, Natalie; Li Zhiru; Carlow, Clotilde; Gokool, Suzanne; Townson, Simon; Kreiss, Tamara; Chojnowski, Agnieszka; Prorok, Monika; Siekierka, John; Ehrens, Alexandra; Koschel, Marianne; Lhermitte-Vallarino, Nathaly; Martin, Coralie; Hoerauf, Achim; Hernandez, Geraldine; Canan, Stacie; Khetani, Vikram; Zeldis, Jerome; Specht, Sabine; Huebner, Marc P.; Scandale, Ivan 分享 收藏 Evaluation of the in vitro susceptibility of various filarial nematodes to emodepsideHuebner, Marc P.; Townson, Simon; Gokool, Suzanne; Tagboto, Senyo; Maclean, Mary J.; Verocai, Guilherme G.; Wolstenholme, Adrian J.; Frohberger, Stefan J.; Hoerauf, Achim; Specht, Sabine; Scandale, Ivan; Harder, Achim; Glenschek-Sieberth, Martin; Hahnel, Steffen R.; Kulke, Daniel 分享 收藏 Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitroHuebner, Marc P.; Martin, Coralie; Specht, Sabine; Koschel, Marianne; Dubben, Bettina; Frohberger, Stefan J.; Ehrens, Alexandra; Fendler, Martina; Struever, Dominique; Mitre, Edward; Vallarino-Lhermitte, Nathaly; Gokool, Suzanne; Lustigman, Sara; Schneider, Manfred; Townson, Simon; Hoerauf, Achim; Scandale, Ivan 分享 收藏 分享 收藏 Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondVan Voorhis, Wesley C.; Adams, John H.; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H.; Alano, Pietro; Alday, Aintzane; Resto, Yesmalie Aleman; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T.; Avery, Simon V.; Avery, Vicky M.; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; Bowling, Tana; Bosch, Juergen; Boucher, Lauren E.; Boyom, Fabrice F.; Brea, Jose; Brennan, Marian; Burton, Audrey; Caffrey, Conor R.; Camarda, Grazia; Carrasquilla, Manuela; Carter, Dee; Cassera, Maria Belen; Cheng, Ken Chih-Chien; Chindaudomsate, Worathad; Chubb, Anthony; Colon, Beatrice L.; Colon-Lopez, Daisy D.; Corbett, Yolanda; Crowther, Gregory J.; Cowan, Noemi; D'Alessandro, Sarah; Le Dang, Na; Delves, Michael; DeRisi, Joseph L.; Du, Alan Y.; Duffy, Sandra; El-Sayed, Shimaa Abd El-Salam; Ferdig, Michael T.; Robledo, Jose A. Fernandez; Fidock, David A.; Florent, Isabelle; Fokou, Patrick V. T.; Galstian, Ani; Javier Gamo, Francisco; Gokool, Suzanne; Gold, Ben; Golub, Todd; Goldgof, Gregory M.; Guha, Rajarshi; Guiguemde, W. Armand; Gural, Nil; Guy, R. Kiplin; Hansen, Michael A. E.; Hanson, Kirsten K.; Hemphill, Andrew; van Huijsduijnen, Rob Hooft; Horii, Takaaki; Horrocks, Paul; Hughes, Tyler B.; Huston, Christopher; Igarashi, Ikuo; Ingram-Sieber, Katrin; Itoe, Maurice A.; Jadhav, Ajit; Jensen, Amornrat Naranuntarat; Jensen, Laran T.; Jiang, Rays H. Y.; Kaiser, Annette; Keiser, Jennifer; Ketas, Thomas; Kicka, Sebastien; Kim, Sunyoung; Kirk, Kiaran; Kumar, Vidya P.; Kyle, Dennis E.; Jose Lafuente, Maria; Landfear, Scott; Lee, Nathan; Lee, Sukjun; Lehane, Adele M.; Li, Fengwu; Little, David; Liu, Liqiong; Llinas, Manuel; Loza, Maria I.; Lubar, Aristea; Lucantoni, Leonardo; Lucet, Isabelle; Maes, Louis; Mancama, Dalu; Mansour, Nuha R.; March, Sandra; McGowan, Sheena; Vera, Iset Medina; Meister, Stephan; Mercer, Luke; Mestres, Jordi; Mfopa, Alvine N.; Misra, Raj N.; Moon, Seunghyun; Moore, John P.; Rodrigues da Costa, Francielly Morais; Mueller, Joachim; Muriana, Arantza; Hewitt, Stephen Nakazawa; Nare, Bakela; Nathan, Carl; Narraidoo, Nathalie; Nawaratna, Sujeevi; Ojo, Kayode K.; Ortiz, Diana; Panic, Gordana; Papadatos, George; Parapini, Silvia; Patra, Kailash; Ngoc Pham; Prats, Sarah; Plouffe, David M.; Poulsen, Sally-Ann; Pradhan, Anupam; Quevedo, Celia; Quinn, Ronald J.; Rice, Christopher A.; Rizk, Mohamed Abdo; Ruecker, Andrea; St Onge, Robert; Ferreira, Rafaela Salgado; Samra, Jasmeet; Robinett, Natalie G.; Schlecht, Ulrich; Schmitt, Marjorie; Villela, Filipe Silva; Silvestrini, Francesco; Sinden, Robert; Smith, Dennis A.; Soldati, Thierry; Spitzmueller, Andreas; Stamm, Serge Maximilian; Sullivan, David J.; Sullivan, William; Suresh, Sundari; Suzuki, Brian M.; Suzuki, Yo; Swamidass, S. Joshua; Taramelli, Donatella; Tchokouaha, Lauve R. Y.; Theron, Anjo; Thomas, David; Tonissen, Kathryn F.; Townson, Simon; Tripathi, Abhai K.; Trofimov, Valentin; Udenze, Kenneth O.; Ullah, Imran; Vallieres, Cindy; Vigil, Edgar; Vinetz, Joseph M.; Phat Voong Vinh; Hoan Vu; Watanabe, Nao-aki; Weatherby, Kate; White, Pamela M.; Wilks, Andrew F.; Winzeler, Elizabeth A.; Wojcik, Edward; Wree, Melanie; Wu, Wesley; Yokoyama, Naoaki; Zollo, Paul H. A.; Abla, Nada; Blasco, Benjamin; Burrows, Jeremy; Laleu, Benoit; Leroy, Didier; Spangenberg, Thomas; Wells, Timothy; Willis, Paul A. 分享 收藏 Characterization of the Ca2+-Gated and Voltage-Dependent K+-Channel Slo-1 of Nematodes and Its Interaction with EmodepsideKulke, Daniel; von Samson-Himmelstjerna, Georg; Miltsch, Sandra M.; Wolstenholme, Adrian J.; Jex, Aaron R.; Gasser, Robin B.; Ballesteros, Cristina; Geary, Timothy G.; Keiser, Jennifer; Townson, Simon; Harder, Achim; Kruecken, Juergen 分享 收藏 分享 收藏 Integrated Dataset of Screening Hits against Multiple Neglected Disease PathogensNwaka, Solomon; Besson, Dominique; Ramirez, Bernadette; Maes, Louis; Matheeussen, An; Bickle, Quentin; Mansour, Nuha R.; Yousif, Fouad; Townson, Simon; Gokool, Suzanne; Cho-Ngwa, Fidelis; Samje, Moses; Misra-Bhattacharya, Shailja; Murthy, P. K.; Fakorede, Foluke; Paris, Jean-Marc; Yeates, Clive; Ridley, Robert; Van Voorhis, Wesley C.; Geary, Timothy 分享 收藏 分享 收藏 
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