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Design, Synthesis, and Evaluation of Antinociceptive Properties of Novel CBD-Based Terpene-Cinnamoyl-Acyl-Hydrazone Analogues 设计、合成及新型CBD基类萜-肉桂酰-酰腙类似物的镇痛活性评价 de Souza, Mikaela Lucinda; de Paiva, Joao Pedro Barros; Franco, Graziella dos Reis Rosa; Gontijo, Vanessa Silva; Alves, Marina Amaral; de Souza, Hygor Marcos Ribeiro; Lontra, Anna Carolina Pereira; de Oliveira, Eduardo Araujo; Giorno, Thais Biondino Sardella; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Fernandes, Patricia Dias; Viegas, Claudio 分享 收藏
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Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer?s disease Vaz, Sarah Macedo; Silva, Matheus de Freitas; Franco, Graziella dos Reis Rosa; Guimaraes, Marcos Jorge R.; da Silva, Fernanda Motta R.; Castro, Newton Gonsalves; Guedes, Isabella Alvim; Dardenne, Laurent E.; Alves, Marina Amaral; da Costa, Rafael Garrett; Pinheiro, Gabriela Beserra; Veras, Leticia Germino; Mortari, Marcia Renata; Pruccoli, Letizia; Tarozzi, Andrea; Viegas Jr, Claudio 分享 收藏
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Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation Cristancho Ortiz, Cindy Juliet; Silva, Matheus de Freitas; Pruccoli, Letizia; Nadur, Nathalia Fonseca; de Azevedo, Luciana Luiza; Kummerle, Arthur Eugen; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Leomil Coelho, Luiz Felipe; Guimaraes, Marcos J.; da Silva, Fernanda M. R.; Castro, Newton; Gontijo, Vanessa Silva; Rojas, Viviana C. T.; de Oliveira, Merelym Ketterym; Vilela, Fabiana Cardoso; Giusti-Paiva, Alexandre; Barbosa, Gisele; Lima, Lidia Moreira; Pinheiro, Gabriela Beserra; Veras, Leticia Germino; Mortari, Marcia Renata; Tarozzi, Andrea; Viegas Jr, Claudio 分享 收藏
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants Guedes, Isabella A.; Costa, Leon S. C.; dos Santos, Karina B.; Karl, Ana L. M.; Rocha, Gregorio K.; Teixeira, Iury M.; Galheigo, Marcelo M.; Medeiros, Vivian; Krempser, Eduardo; Custodio, Fabio L.; Barbosa, Helio J. C.; Nicolas, Marisa F.; Dardenne, Laurent E. 分享 收藏
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Cinnamoyl-N-Acylhydrazone-Donepezil Hybrids: Synthesis and Evaluation of Novel Multifunctional Ligands Against Neurodegenerative Diseases Ortiz, Cindy Juliet Cristancho; Damasio, Caio Miranda; Pruccoli, Letizia; Nadur, Nathalia Fonseca; de Azevedo, Luciana Luiza; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Kummerle, Arthur Eugen; Tarozzi, Andrea; Viegas, Claudio 分享 收藏
Design, Synthesis and Biological Evaluation of Novel TriazoleN-acylhydrazone Hybrids for Alzheimer's Disease Silva, Matheus de Freitas; Lima, Ellen Tardelli; Pruccoli, Letizia; Castro, Newton G.; Guimaraes, Marcos Jorge R.; da Silva, Fernanda M. R.; Nadur, Nathalia Fonseca; de Azevedo, Luciana Luiz; Kummerle, Arthur Eugen; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Gontijo, Vanessa Silva; Tarozzi, Andrea; Viegas, Claudio 分享 收藏
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Design, synthesis, cholinesterase inhibition and molecular modelling study of novel tacrine hybrids with carbohydrate derivatives Bizarro Lopes, Joao Paulo; Silva, Luana; Franarin, Gabriela da Costa; Ceschi, Marco Antonio; Ludtke, Diogo Seibert; Dantas, Rafael Ferreira; Cardoso de Salles, Cristiane Martins; Silva-, Floriano Paes, Jr.; Senger, Mario Roberto; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel 分享 收藏
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates Dias Viegas, Flavia Pereira; Silva, Matheus de Freitas; da Rocha, Miguel Divino; Castelli, Maisa Rosa; Riquiel, Mariana Maximo; Machado, Rafael Pereira; Vaz, Sarah Macedo; Simoes de Lima, Lais Medeiros; Mancini, Karla Cristine; Marques de Oliveira, Patricia Cruz; Morais, Elida Parreira; Gontijo, Vanessa Silva; da Silva, Fernanda Motta R.; da Fonseca Pecanha, Dora D'Alincourt; Castro, Newton Gonsalves; Neves, Gilda A.; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso; Orlandi, Lidiane; Camps, Ihosvany; Veloso, Marcia Paranho; Leomil Coelho, Luis Felipe; Ionta, Marisa; Ferreira-Silva, Guilherme Alvaro; Pereira, Rodrigo Machado; Dardenne, Laurent E.; Guedes, Isabella Alvim; Carneiro Junior, Wellerson de Oliveira; Quaglio Bellozi, Paula Maria; Pinheiro de Oliveira, Antonio Carlos; Ferreira, Fabio Furlan; Pruccoli, Letizia; Tarozzi, Andrea; Viegas, Claudio, Jr. 分享 收藏
Discovery of naphthyl-N-acylhydrazone p38 MAPK inhibitors with in vivo anti-inflammatory and anti-TNF- activity Freitas, Rosana H. C. N.; Cordeiro, Natalia M.; Carvalho, Patricia R.; Alves, Marina A.; Guedes, Isabella A.; Valerio, Tayna S.; Dardenne, Laurent E.; Lima, Lidia M.; Barreiro, Eliezer J.; Fernandes, Patricia D.; Fraga, Carlos A. M. 分享 收藏
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease 新型阿魏酰-多奈哌齐杂合物的设计、合成及作为阿尔茨海默病治疗潜在多靶点药物的评价 Dias, Kris Simone T.; de Paula, Cynthia T.; dos Santos, Thiago; Souza, Isis N. O.; Boni, Marina S.; Guimaraes, Marcos J. R.; da Silva, Fernanda M. R.; Castro, Newton G.; Neves, Gilda A.; Veloso, Clarice C.; Coelho, Marcio M.; de Melo, Ivo Souza F.; Giusti, Fabiana C. V.; Giusti-Paiva, Alexandre; da Silva, Marcelo L.; Dardenne, Laurent E.; Guedes, Isabella A.; Pruccoli, Letizia; Morroni, Fabiana; Tarozzi, Andrea; Viegas, Claudio, Jr. 分享 收藏
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S10013 secretion and a molecular modeling approach Ceschi, Marco Antonio; da Costa, Jessie Sobieski; Bizarro Lopes, Joao Paulo; Camara, Viktor Saraiva; Campo, Leandra Franciscato; de Amorim Borges, Antonio Cesar; Saraiva Goncalves, Carlos Alberto; de Souza, Daniela Fraga; Konrath, Eduardo Luis; Martins Karl, Ana Luiza; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel 分享 收藏
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