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EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers EBNA1抑制剂揭示CDC7和POU2F1是EBV上皮癌中的直接功能靶点 He, Songtao; Terhuja, Niseno; Soldan, Samantha S.; Chen, Christopher; Cassel, Joel; Yin, Xiangfan; Liu, Qin; Chung, Sun Sook; Castro-Munoz, Leonardo Josue; Yoon, Leena; Wang, Jie; Salvino, Joseph M.; Gewurz, Benjamin E.; Tempera, Italo; Messick, Troy E.; Lieberman, Paul M. 分享 收藏
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Kaposi's sarcoma-associated herpesvirus induces mitochondrial fission to evade host immune responses and promote viral production 卡波西肉瘤相关疱疹病毒诱导线粒体分裂以逃避宿主免疫反应并促进病毒产生 Zhu, Qing; Mcelroy, Robert; Machhar, Janvhi Suresh; Cassel, Joel; Zheng, Zihan; Mansoori, Behzad; Guo, Hongrui; Guo, Sen; Pangilinan, Christian; Liang, Jinghui; Shen, Dongliang; Zhang, Lu; Liu, Qin; Kossenkov, Andrew V.; Altieri, Dario C.; Lieberman, Paul M.; Gao, Shou-Jiang; Feng, Pinghui; Murphy, Maureen E.; Song, Jikui; Salvino, Joseph M.; Liang, Qiming; Jung, Jae U.; Liang, Chengyu 分享 收藏
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An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis 对spirooxindoles作为SARS-CoV-2刺突蛋白/ACE2相互作用阻断剂的评估：合成、生物评价和计算分析 Ehinak, Albert Enama; Lobe, Maloba M. M.; Eni, Donatus B.; Simoben, Conrad V.; Tietjen, Ian; Tjegbe, Mathieu J. Mbenga; Cassel, Joel; Salvino, Joseph M.; Montaner, Luis J.; Efange, Simon M. N. 分享 收藏
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Disruption of the Retinoblastoma Lxcxe Region Induces Cell Death in AML By Activation of the Unfolded Protein Response Leading to NOXA Induction 视网膜母细胞瘤Lxcxe区域的功能障碍通过激活未折叠蛋白反应诱导AML细胞死亡，从而导致NOXA的表达上调。 Bhuniya, Avishek; Lu, Lily; Ploi, Adi Narayana Reddy; Tcyganov, Evgenii; Mendoza, Maria De Grecia Cauti; Sharma, Paridhima; Ortiz, Adiana Ochoa; Zhigarev, Dmitry; Salvino, Joseph; Montaner, Luis 分享 收藏
Design of novel and highly selective SARS-CoV-2 main protease inhibitors 新型高选择性SARS-CoV-2主要蛋白酶抑制剂的设计 Poli, Adi N. R.; Tietjen, Ian; Nandwana, Nitesh K.; Cassel, Joel; Messick, Troy E.; Register, Emery T.; Keeney, Frederick; Rajaiah, Rajesh; Verma, Atul K.; Pandey, Kabita; Acharya, Arpan; Byrareddy, Siddappa N.; Montaner, Luis J.; Salvino, Joseph M. 分享 收藏
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer Ferretti, Giulia D. S.; Quaas, Colleen E.; Bertolini, Irene; Zuccotti, Alessandro; Saatci, Ozge; Kashatus, Jennifer A.; Sharmin, Salma; Lu, David Y.; Poli, Adi Narayana Reddy; Quesnelle, Abigail F.; Rodriguez-Blanco, Jezabel; de Cubas, Aguirre A.; Hobbs, G. Aaron; Liu, Qin; O'Bryan, John P.; Salvino, Joseph M.; Kashatus, David F.; Sahin, Ozgur; Barnoud, Thibaut 分享 收藏
Metabolomic Analysis and Antiviral Screening of a Marine Algae Library Yield Jobosic Acid (2,5-Dimethyltetradecanoic Acid) as a Selective Inhibitor of SARS-CoV-2 Matos-Hernandez, Marie L.; Samples, Robert; Dyer, Grayce; Montan, Victoria M. Casimir; Morales-Colon, Chris A.; Salvino, Joseph M.; Montaner, Luis J.; Cassel, Joel A.; Messick, Troy E.; Tietjen, Ian; Caro-Diaz, Eduardo J. E. 分享 收藏
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Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators Fontana, Andreia C. K.; Poli, Adi N. R.; Gour, Jitendra; Srikanth, Yellamelli V. V.; Anastasi, Nicholas; Ashok, Devipriya; Khatiwada, Apeksha; Reeb, Katelyn L.; Cheng, Mary Hongying; Bahar, Ivet; Rawls, Scott M.; Salvino, Joseph M. 分享 收藏
Neutralizing human IFN-ß combined with anti-human PD-L1 and antihuman CTLA-4 treatment increased control of endometrial tumor growth in a novel HLA-A matched BLT humanized mice Yuan, Zhe; Zu, Guorui; Sun, Xiao; Papasavvas, Emmanouil; Lu, Lily; Cassel, Joel; Lutes, Peter L.; Cadungog, Mark; Salvino, Joseph; Montaner, Luis J. 分享 收藏
Targeting retinoblastoma protein in tumor-associated macrophages suppresses ovarian cancer progression Tcyganov, Evgenii N.; Kwak, Taekyoung; Yang, Xue; Poli, Adi N.; Hart, Colin; Bhuniya, Avishek; Cassel, Joel; Kossenkov, Andrew; Auslander, Noam; Sharma, Paridhima; Cadungog, Mark G.; Jean, Stephanie; Chatterjee-Paer, Sudeshna; Weiner, David; Donthireddy, Laxminarasimha; Bristow, Bryan; Zhang, Rugang; Salvino, Joseph M.; Montaner, Luis J. 分享 收藏
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Acetate acts as a metabolic immunomodulator by bolstering T-cell effector function and potentiating antitumor immunity in breast cancer 乙酸盐通过增强T细胞效应子功能和增强乳腺癌的抗肿瘤免疫力而充当代谢免疫调节剂 Miller, Katelyn D.; O'Connor, Seamus; Pniewski, Katherine A.; Kannan, Toshitha; Acosta, Reyes; Mirji, Gauri; Papp, Sara; Hulse, Michael; Mukha, Dzmitry; Hlavaty, Sabina I.; Salcido, Kelsey N.; Bertolazzi, Fabrizio; Srikanth, Yellamelli V. V.; Zhao, Steven; Wellen, Kathryn E.; Shinde, Rahul S.; Claiborne, Daniel T.; Kossenkov, Andrew; Salvino, Joseph M.; Schug, Zachary T. 分享 收藏
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