Alexander W. Schüttelkopf

University of Dundee

27H指数

75论文数

7.3K被引数

收录论文 21

发表时间

Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras 可逆性小分子多变量Ras抑制剂对Ras的活性形式和非活性形式显示出可调节的亲和力。

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-03-31

PREAI

Parry, Charles W.; Pellicano, Francesca; Schuttelkopf, Alexander W.; Beyer, Kim S.; Bower, Justin; Bryson, Amy; Cameron, Kenneth; Cerutti, Nichole M.; Clark, Jonathan P.; Davidson, Stuart C.; Davies, Keneth; Drysdale, Martin J.; Engelman, Jeffrey; Estevan-Barber, Anna; Gohlke, Andrea; Gray, Christopher H.; Guthy, Daniel A.; Hong, Min; Hopkins, Alana; Hutchinson, Luke D.; Konczal, Jennifer; Maira, Michel; McArthur, Duncan; Mezna, Mokdad; McKinnon, Heather; Nepravishta, Ridvan; Ostermann, Nils; Pasquali, Camila C.; Pollock, Katie; Pugliese, Angelo; Rooney, Nicholas; Schmiedeberg, Niko; Shaw, Paul; Velez-Vega, Camilo; West, Christopher; West, Ryan; Zecri, Frederic; Taylor, John B.

The active site of O-GlcNAc transferase imposes constraints on substrate sequence (vol 22, pg 744, 2015)

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2023-03-03

OAAI

Pathak, Shalini; Alonso, Jana; Schimpl, Marianne; Rafie, Karim; Blair, David E. E.; Borodkin, Vladimir S. S.; Schuettelkopf, Alexander W. W.; Albarbarawi, Osama; van Aalten, Daan M. F.

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

CANCER RESEARCH

IF16.6

2018-11-15

OAAI

Birch, Joanna L.; Strathdee, Karen; Gilmour, Lesley; Vallatos, Antoine; McDonald, Laura; Kouzeli, Ariadni; Vasan, Richa; Qaisi, Abdulrahman Hussain; Croft, Daniel R.; Crighton, Diane; Gill, Kathryn; Gray, Christopher H.; Konczal, Jennifer; Mezna, Mokdad; McArthur, Duncan; Schuttelkopf, Alexander W.; McConnell, Patricia; Sime, Mairi; Holmes, William M.; Bower, Justin; McKinnon, Heather J.; Drysdale, Martin; Olson, Michael F.; Chalmers, Anthony J.

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

CANCER RESEARCH

IF16.6

2018-04-12

OAAI

Unbekandt, Mathieu; Belshaw, Simone; Bower, Justin; Clarke, Maeve; Cordes, Jacqueline; Crighton, Diane; Croft, Daniel R.; Drysdale, Martin J.; Garnett, Mathew J.; Gill, Kathryn; Gray, Christopher; Greenhalgh, David A.; Hall, James A. M.; Konczal, Jennifer; Lilla, Sergio; McArthur, Duncan; McConnell, Patricia; McDonald, Laura; McGarry, Lynn; McKinnon, Heather; McMenemy, Carol; Mezna, Mokdad; Morrice, Nicolas A.; Munro, June; Naylor, Gregory; Rath, Nicola; Schuttelkopf, Alexander W.; Sime, Mairi; Olson, Michael F.

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

NATURE STRUCTURAL & MOLECULAR BIOLOGY

IF10.1

2015-08-03

127

OAAI

Pathak, Shalini; Alonso, Jana; Schimpl, Marianne; Rafie, Karim; Blair, David E.; Borodkin, Vladimir S.; Schuettelkopf, Alexander W.; Albarbarawi, Osama; van Aalten, Daan M. F.

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

CELL COMMUNICATION AND SIGNALING

IF8.9

2014-10-05

OAAI

Unbekandt, Mathieu; Croft, Daniel R.; Crighton, Diane; Mezna, Mokdad; McArthur, Duncan; McConnell, Patricia; Schuettelkopf, Alexander W.; Belshaw, Simone; Pannifer, Andrew; Sime, Mairi; Bower, Justin; Drysdale, Martin; Olson, Michael F.

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

NATURE CHEMICAL BIOLOGY

IF13.7

2012-10-28

134

OAAI

Schimpl, Marianne; Zheng, Xiaowei; Borodkin, Vladimir S.; Blair, David E.; Ferenbach, Andrew T.; Schuettelkopf, Alexander W.; Navratilova, Iva; Aristotelous, Tonia; Albarbarawi, Osama; Robinson, David A.; Macnaughtan, Megan A.; van Aalten, Daan M. F.

Bisdionin C-A Rationally Designed, Submicromolar Inhibitor of Family 18 Chitinases

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2011-03-23

OAAI

Schuettelkopf, Alexander W.; Andersen, Ole A.; Rao, Francesco V.; Allwood, Matthew; Rush, Christina L.; Eggleston, Ian M.; van Aalten, Daan M. F.

Charge-Surrounded Pockets and Electrostatic Interactions with Small Ions Modulate the Activity of Retroviral Fusion Proteins

PLOS PATHOGENS

IF4.9

2011-02-03

OAAI

Lamb, Daniel; Schuettelkopf, Alexander W.; van Aalten, Daan M. F.; Brighty, David W.

Acetazolamide-based fungal chitinase inhibitors 基于乙酰唑胺的真菌几丁质酶抑制剂

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2010-12-01

OAAI

Schuettelkopf, Alexander W.; Gros, Ludovic; Blair, David E.; Frearson, Julie A.; van Aalten, Daan M. F.; Gilbert, Ian H.

Human OGA binds substrates in a conserved peptide recognition groove

BIOCHEMICAL JOURNAL

IF4.3

2010-10-25

OAAI

Schimpl, Marianne; Schuettelkopf, Alexander W.; Borodkin, Vladimir S.; van Aalten, Daan M. F.

Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2009-03-01

OAAI

Hurtado-Guerrero, Ramon; Schuettelkopf, Alexander W.; Mouyna, Isabelle; Ibrahim, Adel F. M.; Shepherd, Sharon; Fontaine, Thierry; Latge, Jean-Paul; van Aalten, Daan M. F.

Structural insights into mechanism and specificity of O-GlcNAc transferase

EMBO JOURNAL

IF8.3

2008-09-25

122

OAAI

Clarke, Andrew J.; Hurtado-Guerrero, Ramon; Pathak, Shalini; Schuttelkopf, Alexander W.; Borodkin, Vladimir; Shepherd, Sharon M.; Ibrahim, Adel F. M.; van Aalten, Daan M. F.

TAK1-binding protein 1 is a pseudophosphatase TAK1-binding蛋白1是一种假磷酸酶

BIOCHEMICAL JOURNAL

IF4.3

2006-10-13

OAAI

Conner, Sarah H.; Kular, Gursant; Peggie, Mark; Shepherd, Sharon; Schuttelkopf, Alexander W.; Cohen, Philip; Van Aalten, Daan M. F.

Screening-based discovery and structural dissection of a novel family 18 chitinase inhibitor

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2006-09-01

OAAI

Schuttelkopf, Alexander W.; Andersen, Ole A.; Rao, Francesco V.; Allwood, Matthew; Lloyd, Clare; Eggleston, Ian M.; Van Aalten, Daan M. F.