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N

Nunzio Sciammetta

pfizer united kingdom
H指数:15
被引数:751

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Diminishing GSH-Adduct Formation of Tricyclic Diazepine-basedMutant IDH1 Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2022-03-283
OA
Huang, Chunhui; Fischer, Christian; Machacek, Michelle R.; Bogen, Stephane; Biftu, Tesfaye; Huang, Xianhai; Reutershan, Michael H.; Otte, Ryan; Hong, Qingmei; Wu, Zhicai; Yu, Yang; Park, Min; Chen, Lei; Biju, Purakkattle; Knemeyer, Ian; Lu, Ping; Kochansky, Christopher J.; Hicks, Michael Brendan; Liu, Yong; Helmy, Roy; Fradera, Xavier; Donofrio, Anthony; Close, Josh; Maddess, Matthew L.; White, Catherine; Sloman, David L.; Sciammetta, Nunzio; Lu, Jun; Gibeau, Craig; Simov, Vladimir; Zhang, Hongjun; Fuller, Peter; Witter, David
Oxetane Promise Delivered: Discovery of Long-Acting IDO1Inhibitors Suitable for Q3W Oral or Parenteral Dosing
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-03-0311
PRE
Li, Derun; Sloman, David L.; Achab, Abdelghani; Zhou, Hua; McGowan, Meredeth A.; White, Catherine; Gibeau, Craig; Zhang, Hongjun; Pu, Qinglin; Bharathan, Indu; Hopkins, Brett; Liu, Kun; Ferguson, Heidi; Fradera, Xavier; Lesburg, Charles A.; Martinot, Theodore A.; Qi, Ji; Song, Zhiguo J.; Yin, Jingjun; Zhang, Huangguang; Song, Licheng; Wan, Baoqiang; DAddio, Suzanne; Solban, Nicolas; Miller, J. Richard; Zamlynny, Beata; Bass, Alan; Freeland, Elizabeth; Ykoruk, Bridget; Hilliard, Catherine; Ferraro, Jude; Zhai, Jin; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2021-02-2617
OA
Li, Derun; Deng, Yongqi; Achab, Abdelghani; Bharathan, Indu; Hopkins, Brett Andrew; Yu, Wensheng; Zhang, Hongjun; Sanyal, Sulagna; Pu, Qinglin; Zhou, Hua; Liu, Kun; Lim, Jongwon; Fradera, Xavier; Lesburg, Charles A.; Lammens, Alfred; Martinot, Theodore A.; Cohen, Ryan D.; Doty, Amy C.; Ferguson, Heidi; Nickbarg, Elliott B.; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Abeywickrema, Pravien; Andrews, Christine; Chamberlin, Chad; Mabrouk, Omar; Curran, Patrick; Richards, Matthew; Saradjian, Peter; Miller, J. Richard; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors

发现有效且可口服的双环 [1.1.1] 戊烷衍生的Indoleamine-2，3-双加氧酶1 (IDO1) 抑制剂

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2020-07-1557
OAAI
Pu, Qinglin; Zhang, Hongjun; Guo, Liangqin; Cheng, Mangeng; Doty, Amy C.; Ferguson, Heidi; Fradera, Xavier; Lesburg, Charles A.; McGowan, Meredeth A.; Miller, J. Richard; Geda, Prasanthi; Song, Xuelei; Otte, Karin; Sciammetta, Nunzio; Solban, Nicolas; Yu, Wensheng; Sloman, David L.; Zhou, Hua; Lammens, Alfred; Neumann, Lars; Bennett, David Jonathan; Pasternak, Alexander; Han, Yongxin
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)

在Indoleamine-2，3-双加氧酶-1 (IDO1) 的血红素置换抑制剂中战略性地掺入极性

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2020-03-1028
OAAI
White, Catherine; McGowan, Meredeth A.; Zhou, Hua; Sciammetta, Nunzio; Fradera, Xavier; Lim, Jongwon; Joshi, Elizabeth M.; Andrews, Christine; Nickbarg, Elliott B.; Cowley, Phillip; Trewick, Sarah; Augustin, Martin; von Koeenig, Konstanze; Lesburg, Charles A.; Otte, Karin; Knemeyer, Ian; Woo, Hyun; Yu, Wensheng; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Curran, Patrick; Heo, Mee Ra; Abeywickrema, Pravien; Miller, J. Richard; Bennett, David Jonathan; Han, Yongxin
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2020-01-0920
OAAI
Zhang, Hongjun; Lapointe, Blair T.; Anthony, Neville; Azevedo, Rita; Cals, Jos; Correll, Craig C.; Daniels, Matthew; Deshmukh, Sujal; van Eenenaam, Hans; Ferguson, Heidi; Hegde, Laxminarayan G.; Karstens, Willem Jan; Maclean, John; Miller, J. Richard; Moy, Lily Y.; Simov, Vladimir; Nagpal, Sunil; Oubrie, Arthur; Palte, Rachel L.; Parthasarathy, Gopal; Sciammetta, Nunzio; van der Stelt, Mario; Woodhouse, Janice D.; Trotter, B. Wesley; Barr, Kenneth
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy

发现用于癌症免疫疗法的氨基-环丁基芳烃衍生的Indoleamine-2，3-双加氧酶1 (IDO1) 抑制剂

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2019-09-1838
OAAI
Zhang, Hongjun; Liu, Kun; Pu, Qinglin; Achab, Abdelghani; Ardolino, Michael J.; Cheng, Mangeng; Deng, Yongqi; Doty, Amy C.; Ferguson, Heidi; Fradera, Xavier; Knemeyer, Ian; Kurukulasuriya, Ravi; Lam, Yu-hong; Lesburg, Charles A.; Martinot, Theodore A.; McGowan, Meredeth A.; Miller, J. Richard; Otte, Karin; Biju, Purakattle J.; Sciammetta, Nunzio; Solban, Nicolas; Yu, Wensheng; Zhou, Hua; Wang, Xiao; Bennett, David Jonathan; Han, Yongxin
Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2017-05-0520
PREAI
Sanders, John M.; Beshore, Douglas C.; Culberson, J. Christopher; Fells, James I.; Imbriglio, Jason E.; Gunaydin, Hakan; Haidle, Andrew M.; Labroli, Marc; Mattioni, Brian E.; Sciammetta, Nunzio; Shipe, William D.; Sheridan, Robert P.; Suen, Linda M.; Verras, Andreas; Walji, Abbas; Joshi, Elizabeth M.; Bueters, Tjerk
Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-11-08209
OAAI
Fish, Paul V.; Filippakopoulos, Panagis; Bish, Gerwyn; Brennan, Paul E.; Bunnage, Mark E.; Cook, Andrew S.; Federov, Oleg; Gerstenberger, Brian S.; Jones, Hannah; Knapp, Stefan; Marsden, Brian; Nocka, Karl; Owen, Dafydd R.; Philpott, Martin; Picaud, Sarah; Primiano, Michael J.; Ralph, Michael J.; Sciammetta, Nunzio; Trzupek, John D.

研究方向

暂未获取到该数据
X
Xavier Fradera
H 指数:28论文数:99被引数:3,826
H
Hongjun Zhang
H 指数:16论文数:29被引数:734
J
J. Richard Miller
H 指数:32论文数:95被引数:5,287
D
David Jonathan Bennett
H 指数:25论文数:82被引数:2,561
周
周华
H 指数:20论文数:55被引数:1,471
C
Charles A. Lesburg
H 指数:27论文数:85被引数:3,891
I
Ian Knemeyer
H 指数:16论文数:45被引数:1,635
Y
Yongxin Han
H 指数:36论文数:171被引数:4,454
K
Karin M. Otte
H 指数:16论文数:41被引数:741
H
Heidi M. Ferguson
H 指数:14论文数:38被引数:715