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B

Bogdan I. Florea

Leiden University
H指数:48
被引数:7,408

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工作经历

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Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system

卡非佐米特异性蛋白酶体β5/β2抑制通过重塑蛋白质稳态和肾素-血管紧张素系统驱动心脏毒性。

iScience
IF4.1
2025-07-290
OA
Max Mendez-Lopez; Andrej Besse; Christian Zuppinger; Christian Perez-Shibayama; Cristina Gil-Cruz; Bogdan I. Florea; Angelina De Martin; Mechthild Lütge; Deborah Beckerova; Simon Klimovic; Xiang Zhou; Leo Rasche; Jan Pribyl; Vladimir Rotrekl; Burkhard Ludewig; Herman S. Overkleeft; Lenka Besse; Christoph Driessen
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
IF7.4
2024-06-011
OAAI
Schaftenaar, Frank H.; van Dam, Andrea D.; de Bruin, Gerjan; Depuydt, Marie A. C.; de Mol, Jill; Amersfoort, Jacob; Douna, Hidde; Meijer, Menno; Kroener, Mara J.; van Santbrink, Peter J.; Kleijn, Mireia N. A. Bernabe; van Puijvelde, Gijs H. M.; Florea, Bogdan I.; Sluetter, Bram; Foks, Amanda C.; Bot, Ilze; Rensen, Patrick C. N.; Kuiper, Johan
Amonoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence
NATURE COMMUNICATIONS
IF15.7
2023-12-057
OAAI
Jiang, Ming; Huizenga, Mirjam C. W.; Wirt, Jonah L.; Paloczi, Janos; Amedi, Avand; van den Berg, Richard J. B. H. N.; Benz, Joerg; Collin, Ludovic; Deng, Hui; Di, Xinyu; Driever, Wouter F.; Florea, Bogdan I.; Grether, Uwe; Janssen, Antonius P. A.; Hankemeier, Thomas; Heitman, Laura H.; Lam, Tsang-Wai; Mohr, Florian; Pavlovic, Anto; Ruf, Iris; van den Hurk, Helma; Stevens, Anna F.; van der Vliet, Daan; van der Wel, Tom; Wittwer, Matthias B.; van Boeckel, Constant A. A.; Pacher, Pal; Hohmann, Andrea G.; van der Stelt, Mario
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis (vol 14, 2114, 2023)
NATURE COMMUNICATIONS
IF15.7
2023-04-280
OAAI
Reichelt, Julia; Sachs, Wiebke; Frombling, Sarah; Fehlert, Julia; Studencka-Turski, Maja; Betz, Anna; Loreth, Desiree; Blume, Lukas; Witt, Susanne; Pohl, Sandra; Brand, Johannes; Czesla, Maire; Knop, Jan; Florea, Bogdan I.; Zielinski, Stephanie; Sachs, Marlies; Hoxha, Elion; Hermans-Borgmeyer, Irm; Zahner, Gunther; Wiech, Thorsten; Kruger, Elke; Meyer-Schwesinger, Catherine
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis
NATURE COMMUNICATIONS
IF15.7
2023-04-138
OAAI
Reichelt, Julia; Sachs, Wiebke; Froembling, Sarah; Fehlert, Julia; Studencka-Turski, Maja; Betz, Anna; Loreth, Desiree; Blume, Lukas; Witt, Susanne; Pohl, Sandra; Brand, Johannes; Czesla, Maire; Knop, Jan; Florea, Bogdan I.; Zielinski, Stephanie; Sachs, Marlies; Hoxha, Elion; Hermans-Borgmeyer, Irm; Zahner, Gunther; Wiech, Thorsten; Krueger, Elke; Meyer-Schwesinger, Catherine
High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to low-dose carfilzomib by co-inhibiting the 132 and 131 subunits of the proteasome complex
HAEMATOLOGICA
IF7.9
2023-02-025
OAAI
Zhou, Xiang; Besse, Andrej; Peter, Jessica; Steinhardt, Maximilian Johannes; Vogt, Cornelia; Nerreter, Silvia; Teufel, Eva; Stanojkovska, Emilia; Xiao, Xianghui; Hornburger, Hannah; Haertle, Larissa; Mendez-Lopez, Max; Munawar, Umair; Riedel, Angela; Han, Seungbin; Maurits, Elmer; Overkleeft, Herman S.; Florea, Bogdan; Einsele, Hermann; Kortuem, K. Martin; Driessen, Christoph; Besse, Lenka; Rasche, Leo
Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
CANCER RESEARCH
IF16.6
2021-06-229
OAAI
Besse, Lenka; Besse, Andrej; Stolze, Sara C.; Sobh, Amin; Zaal, Esther A.; van der Ham, Alwin J.; Ruiz, Mario; Phuyal, Santosh; Buechler, Lorina; Sathianathan, Marc; Florea, Bogdan I.; Boren, Jan; Stahlman, Marcus; Huber, Julia; Bolomsky, Arnold; Ludwig, Heinz; Hannich, J. Thomas; Loguinov, Alex; Everts, Bart; Berkers, Celia R.; Pilon, Marc; Farhan, Hesso; Vulpe, Christopher D.; Overkleeft, Herman S.; Driessen, Christoph

研究方向

暂未获取到该数据
H
Herman S. Overkleeft
H 指数:83论文数:928被引数:2.8万
M
Mario van der Stelt
H 指数:49论文数:224被引数:9,949
G
Gijsbert A. van der Marel
H 指数:49论文数:256被引数:7,574
J
Johannes M. F. G. Aerts
H 指数:94论文数:610被引数:2.8万
J
Jeroen D. C. Codée
H 指数:53论文数:376被引数:1.0万
G
G.J. Davies
H 指数:105论文数:973被引数:4.6万
C
Christoph Driessen
H 指数:57论文数:292被引数:1.1万
R
Rolf G. Boot
H 指数:57论文数:153被引数:1.1万
W
Wouter W. Kallemeijn
H 指数:29论文数:67被引数:2,511
C
C.J. Kuo
H 指数:16论文数:43被引数:826