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L

Leila N. Varghese

Ludwig Institute for Cancer Research
H指数:16
被引数:3,183

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A typical acute lymphoblastic leukemia JAK2 variant, R683G, causes an aggressive form of familial thrombocytosis when germline

典型的急性淋巴细胞白血病JAK2变体R683G在种系时会导致家族性血小板增多症的侵袭性形式

LEUKEMIA
IF13.4
2021-04-123
PREAI
Carreno-Tarragona, Gonzalo; Varghese, Leila N.; Sebastian, Elena; Galvez, Eva; Marin-Sanchez, Alberto; Lopez-Munoz, Nieves; Nam-Cha, Syonghyun; Martinez-Lopez, Joaquin; Constantinescu, Stefan N.; Sevilla, Julian; Ayala, Rosa
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
NATURE COMMUNICATIONS
IF15.7
2020-06-1974
OAAI
Hildebrand, Joanne M.; Kauppi, Maria; Majewski, Ian J.; Liu, Zikou; Cox, Allison J.; Miyake, Sanae; Petrie, Emma J.; Silk, Michael A.; Li, Zhixiu; Tanzer, Maria C.; Brumatti, Gabriela; Young, Samuel N.; Hall, Cathrine; Garnish, Sarah E.; Corbin, Jason; Stutz, Michael D.; Di Rago, Ladina; Gangatirkar, Pradnya; Josefsson, Emma C.; Rigbye, Kristin; Anderton, Holly; Rickard, James A.; Tripaydonis, Anne; Sheridan, Julie; Scerri, Thomas S.; Jackson, Victoria E.; Czabotar, Peter E.; Zhang, Jian-Guo; Varghese, Leila; Allison, Cody C.; Pellegrini, Marc; Tannahill, Gillian M.; Hatchell, Esme C.; Willson, Tracy A.; Stockwell, Dina; de Graaf, Carolyn A.; Collinge, Janelle; Hilton, Adrienne; Silke, Natasha; Spall, Sukhdeep K.; Chau, Diep; Athanasopoulos, Vicki; Metcalf, Donald; Laxer, Ronald M.; Bassuk, Alexander G.; Darbro, Benjamin W.; Singh, Maria A. Fiatarone; Vlahovich, Nicole; Hughes, David; Kozlovskaia, Maria; Ascher, David B.; Warnatz, Klaus; Venhoff, Nils; Thiel, Jens; Biben, Christine; Blum, Stefan; Reveille, John; Hildebrand, Michael S.; Vinuesa, Carola G.; McCombe, Pamela; Brown, Matthew A.; Kile, Benjamin T.; McLean, Catriona; Bahlo, Melanie; Masters, Seth L.; Nakano, Hiroyasu; Ferguson, Polly J.; Murphy, James M.; Alexander, Warren S.; Silke, John
Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analyses

从生化和结构分析了解骨髓增生性肿瘤相关JAK2突变体的激活和SOCS3-mediated抑制的机理

BIOCHEMICAL JOURNAL
IF4.3
2014-02-1433
OAAI
Varghese, Leila N.; Ungureanu, Daniela; Liau, Nicholas P. D.; Young, Samuel N.; Laktyushin, Artem; Hammaren, Henrik; Lucet, Isabelle S.; Nicola, Nicos A.; Silvennoinen, Olli; Babon, Jeffrey J.; Murphy, James M.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
BIOCHEMICAL JOURNAL
IF4.3
2013-12-20241
OAAI
Murphy, James M.; Zhang, Qingwei; Young, Samuel N.; Reese, Michael L.; Bailey, Fiona P.; Eyers, Patrick A.; Ungureanu, Daniela; Hammaren, Henrik; Silvennoinen, Olli; Varghese, Leila N.; Chen, Kelan; Tripaydonis, Anne; Jura, Natalia; Fukuda, Koichi; Qin, Jun; Nimchuk, Zachary; Mudgett, Mary Beth; Elowe, Sabine; Gee, Christine L.; Liu, Ling; Daly, Roger J.; Manning, Gerard; Babon, Jeffrey J.; Lucet, Isabelle S.
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

假激酶MLKL通过分子开关机制介导坏死性凋亡

IMMUNITY
IF26.3
2013-09-011.0K
OA
Murphy, James M.; Czabotar, Peter E.; Hildebrand, Joanne M.; Lucet, Isabelle S.; Zhang, Jian-Guo; Alvarez-Diaz, Silvia; Lewis, Rowena; Lalaoui, Najoua; Metcalf, Donald; Webb, Andrew I.; Young, Samuel N.; Varghese, Leila N.; Tannahill, Gillian M.; Hatchell, Esme C.; Majewski, Ian J.; Okamoto, Toru; Dobson, Renwick C. J.; Hilton, Douglas J.; Babon, Jeffrey J.; Nicola, Nicos A.; Strasser, Andreas; Silke, John; Alexander, Warren S.

研究方向

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J
James M. Murphy
H 指数:89论文数:488被引数:2.6万
J
Jeffrey J. Babon
H 指数:47论文数:147被引数:1.0万
N
Nicos A. Nicola
H 指数:96论文数:423被引数:3.7万
I
Isabelle S. Lucet
H 指数:34论文数:101被引数:7,155
S
Samuel N. Young
H 指数:26论文数:56被引数:4,665
S
Stefan N. Constantinescu
H 指数:67论文数:344被引数:1.9万
J
John Silke
H 指数:91论文数:370被引数:3.7万
J
Joanne M. Hildebrand
H 指数:29论文数:72被引数:4,762
W
Warren S. Alexander
H 指数:83论文数:319被引数:2.9万
A
Artem Laktyushin
H 指数:8论文数:21被引数:1,129