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J

Jake Y. Henry

Garvan Institute of Medical Research
H指数:23
被引数:8,274

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Energy-guided combinatorial co-optimization of antibody affinity and stability

抗体亲和力与稳定性的能量引导组合协同优化

Nature Communications
IF15.7
2026-11-050
OAAI
Ariel Tennenhouse; Adva Mechaly; Tony Pham; Robert J. Oldham; Jake Y. Henry; Dorry X. Zhao; Thomas M. Moon; Isabel G. Elliott; Omri Porat; Jinny Kim; Yael Fridmann Sirkis; Sveta Gaiduk; Itay Talpir; Jamie Bird; Christopher Domalewski; Pei-Hsuan Chu; Andrew B. Dippel; Rebecca Croasdale-Wood; Daniel Christ; Gilad Kaplan; Mark S. Cragg; Sarel J. Fleishman
Humoral epitope dominance and immune imprinting by SARS-CoV-1 and SARS-CoV-2 vaccines

SARS-CoV-1和SARS-CoV-2疫苗诱导的体液表位优势和免疫印迹

Immunology and Cell Biology
IF3
2026-01-010
OAAI
Burnett, Deborah L.; Moxon, Ania; Aggarwal, Anupriya; Jackson, Katherine J. L.; Cotter, Catherine; Akerman, Anouschka; Russell, Amanda; Kalman, Rachel; Langley, David; Henry, Jake Y.; Christ, Daniel; Bull, Rowena A.; Brink, Robert; Kelleher, Anthony D.; Jack, Hans-Martin; Turville, Stuart; Moss, Bernard; Goodnow, Christopher C.
Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis

靶向突变型p53依赖性胰腺癌中的NPY/NPY1R信号轴抑制了转移

SCIENCE ADVANCES
IF12.5
2025-03-140
PRE
Chambers, Cecilia R.; Watakul, Supitchaya; Schofield, Peter; Howell, Anna E.; Zhu, Jessie; Tran, Alice M. H.; Kuepper, Nadia; Reed, Daniel A.; Murphy, Kendelle J.; Channon, Lily M.; Pereira, Brooke A.; Tyma, Victoria M.; Lee, Victoria; Trpceski, Michael; Henry, Jake; Melenec, Pauline; Abdulkhalek, Lea; Nobis, Max; Metcalf, Xanthe L.; Ritchie, Shona; Cadell, Antonia; Stoehr, Janett; Magenau, Astrid; Chacon-Fajardo, Diego; Chitty, Jessica L.; O'Connell, Savannah; Zaratzian, Anaiis; Tayao, Michael; Da Silva, Andrew; Lyons, Ruth J.; Goldstein, Leonard D.; Dale, Ashleigh; Rookyard, Alexander; Connolly, Angela; Crossett, Ben; Tran, Yen T. H.; Kaltzis, Peter; Vennin, Claire; Dinevska, Marija; Croucher, David R.; Samra, Jaswinder; Mittal, Anubhav; Weatheritt, Robert J.; Philp, Andrew; Del Monte-Nieto, Gonzalo; Zhang, Lei; Enriquez, Ronaldo F.; Cox, Thomas R.; Shi, Yan-Chuan C.; Pinese, Mark; Waddell, Nicola; Sim, Hao-Wen; Wang, Yingxiao; Joshua, Anthony M.; Chantrill, Lorraine; Evans, Thomas R. Jeffry; Gill, Anthony J.; Morton, Jennifer P.; Pajic, Marina; Herzog, Herbert; Timpson, Paul; Herrmann, David
Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies

亲和力成熟赋予6类SARS-CoV-2广谱中和抗体强大的活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2025-01-020
OA
Mazigi, Ohan; Langley, David B.; Henry, Jake Y.; Burnett, Deborah L.; Sobti, Meghna; Walker, GregoryJ.; Rouet, Romain; Balachandran, Harikrishnan; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Schofield, Peter; Brown, Simon H. J.; Schulz, Sebastian R.; Hoffmann, Markus; Poehlmann, Stefan; Post, Jeffrey; Martinello, Marianne; Kelleher, Anthony; Rawlinson, William D.; Turville, Stuart G.; Bull, Rowena A.; Stewart, Alastair G.; Jaeck, Hans-Martin; Goodnow, Christopher C.; Christ, Daniel
Human genomic DNA is widely interspersed with i-motif structures

人类基因组DNA广泛散布着i-motif结构

EMBO JOURNAL
IF8.3
2024-08-292
OAAI
Martinez, Cristian David Pena; Zeraati, Mahdi; Rouet, Romain; Mazigi, Ohan; Henry, Jake Y.; Gloss, Brian; Kretzmann, Jessica A.; Evans, Cameron W.; Ruggiero, Emanuela; Zanin, Irene; Marusic, Maja; Plavec, Janez; Richter, Sara N.; Bryan, Tracy M.; Smith, Nicole M.; Dinger, Marcel E.; Kummerfeld, Sarah; Christ, Daniel
Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

通过基于表位的选择从恢复期患者中广泛中和SARS-CoV-2抗体

NATURE COMMUNICATIONS
IF15.7
2023-02-0819
OAAI
Rouet, Romain; Henry, Jake Y.; Johansen, Matt D.; Sobti, Meghna; Balachandran, Harikrishnan; Langley, David B.; Walker, Gregory J.; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Mazigi, Ohan; Schofield, Peter; Burnett, Deborah L.; Brown, Simon H. J.; Martinello, Marianne; Hudson, Bernard; Gilroy, Nicole; Post, Jeffrey J.; Kelleher, Anthony; Jaeck, Hans-Martin; Goodnow, Christopher C.; Turville, Stuart G.; Rawlinson, William D.; Bull, Rowena A.; Stewart, Alastair G.; Hansbro, Philip M.; Christ, Daniel
Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability
IMMUNITY
IF26.3
2021-12-0137
OAAI
Burnett, Deborah L.; Jackson, Katherine J. L.; Langley, David B.; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D.; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M.; Singh, Mandeep; Li, Hui; Henry, Jake Y.; Jackson, Jennifer; Stewart, Alastair G.; Witthauer, Franka; Spence, Matthew A.; Hansbro, Nicole G.; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R.; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J.; Rawlinson, William D.; Karl, Rudolfo; Schaefer, Simon; Winkler, Thomas H.; Brink, Robert; Bull, Rowena A.; Hansbro, Philip M.; Jaeck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher C.
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
MABS
IF7.3
2021-05-2416
OAAI
Rouet, Romain; Mazigi, Ohan; Walker, Gregory J.; Langley, David B.; Sobti, Meghna; Schofield, Peter; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Henry, Jake Y.; Abayasingam, Arunasingam; Burnett, Deborah; Kelleher, Anthony; Brink, Robert; Bull, Rowena A.; Turville, Stuart; Stewart, Alastair G.; Goodnow, Christopher C.; Rawlinson, William D.; Christ, Daniel
CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

保留效应T细胞IL-2信号的CD25-Treg-depleting抗体增强效应激活和抗肿瘤免疫

NATURE CANCER
IF28.5
2020-11-09119
OAAI
Solomon, Isabelle; Amann, Maria; Goubier, Anne; Arce Vargas, Frederick; Zervas, Dimitrios; Qing, Chen; Henry, Jake Y.; Ghorani, Ehsan; Akarca, Ayse U.; Marafioti, Teresa; sledzinska, Anna; Werner Sunderland, Mariana; Franz Demane, Dafne; Clancy, Joanne Ruth; Georgiou, Andrew; Salimu, Josephine; Merchiers, Pascal; Brown, Mark Adrian; Flury, Reto; Eckmann, Jan; Murgia, Claudio; Sam, Johannes; Jacobsen, Bjoern; Marrer-Berger, Estelle; Boetsch, Christophe; Belli, Sara; Leibrock, Lea; Benz, Joerg; Koll, Hans; Sutmuller, Roger; Peggs, Karl S.; Quezada, Sergio A.
Immune Surveillance in Clinical Regression of Preinvasive Squamous Cell Lung Cancer
CANCER DISCOVERY
IF33.3
2020-10-0162
OAAI
Pennycuick, Adam; Teixeira, Vitor H.; AbdulJabbar, Khalid; Raza, Shan E. Ahmed; Lund, Tom; Akarca, Ayse U.; Rosenthal, Rachel; Kalinke, Lukas; Chandrasekharan, Deepak P.; Pipinikas, Christodoulos P.; Lee-Six, Henry; Hynds, Robert E.; Gowers, Kate H. C.; Henry, Jake Y.; Millar, Fraser R.; Hagos, Yeman B.; Denais, Celine; Falzon, Mary; Moore, David A.; Antoniou, Sophia; Durrenberger, Pascal F.; Furness, Andrew J.; Carroll, Bernadette; Marceaux, Claire; Asselin-Labat, Marie-Liesse; Larson, William; Betts, Courtney; Coussens, Lisa M.; Thakrar, Ricky M.; George, Jeremy; Swanton, Charles; Thirlwell, Christina; Campbell, Peter J.; Marafioti, Teresa; Yuan, Yinyin; Quezada, Sergio A.; McGranahan, Nicholas; Janes, Sam M.
Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4+PD-1+ Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma
CLINICAL CANCER RESEARCH
IF10.2
2020-07-0149
OAAI
Alrasheed, Nouf; Lee, Lydia; Ghorani, Ehsan; Henry, Jake Y.; Conde, Lucia; Chin, Melody; Galas-Filipowicz, Daria; Furness, Andrew J. S.; Chavda, Selina J.; Richards, Huw; De-Silva, Dunnya; Cohen, Oliver C.; Patel, Dominic; Brooks, Anthony; Rodriguez-Justo, Manuel; Pule, Martin; Herrero, Javier; Quezada, Sergio A.; Yong, Kwee L.
The T cell differentiation landscape is shaped by tumour mutations in lung cancer
NATURE CANCER
IF28.5
2020-05-2274
OA
Ghorani, Ehsan; Reading, James L.; Henry, Jake Y.; de Massy, Marc Robert; Rosenthal, Rachel; Turati, Virginia; Joshi, Kroopa; Furness, Andrew J. S.; Aissa, Assma Ben; Saini, Sunil Kumar; Ramskov, Sofie; Georgiou, Andrew; Sunderland, Mariana Werner; Wong, Yien Ning Sophia; De Mucha, Maria Vila; Day, William; Galvez-Cancino, Felipe; Becker, Pablo D.; Uddin, Imran; Ismail, Mazlina; Ronel, Tahel; Woolston, Annemarie; Jamal-Hanjani, Mariam; Veeriah, Selvaraju; Birkbak, Nicolai J.; Wilson, Gareth A.; Litchfield, Kevin; Conde, Lucia; Guerra-Assuncao, Jose Afonso; Blighe, Kevin; Biswas, Dhruva; Salgado, Roberto; Lund, Tom; Al Bakir, Maise; Moore, David A.; Hiley, Crispin T.; Loi, Sherene; Sun, Yuxin; Yuan, Yinyin; AbdulJabbar, Khalid; Turajilic, Samra; Herrero, Javier; Enver, Tariq; Hadrup, Sine R.; Hackshaw, Allan; Peggs, Karl S.; McGranahan, Nicholas; Chain, Benny; Swanton, Charles; Quezada, Sergio A.
Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors
IMMUNITY
IF26.3
2017-04-01368
OAAI
Vargas, Frederick Arce; Furness, Andrew J. S.; Solomon, Isabelle; Joshi, Kroopa; Mekkaoui, Leila; Lesko, Marta H.; Rota, Enrique Miranda; Dahan, Rony; Georgiou, Andrew; Sledzinska, Anna; Ben Aissa, Assma; Franz, Dafne; Sunderland, Mariana Werner; Wong, Yien Ning Sophia; Henry, Jake Y.; O'Brien, Tim; Nicol, David; Challacombe, Ben; Beers, Stephen A.; Turajlic, Samra; Gore, Martin; Larkin, James; Swanton, Charles; Chester, Kerry A.; Pule, Martin; Ravetch, Jeffrey V.; Marafioti, Teresa; Peggs, Karl S.; Quezada, Sergio A.
The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

Ly6Chi单核细胞的异质性控制其分化为iNOS巨噬细胞或单核细胞衍生的树突状细胞

IMMUNITY
IF26.3
2016-12-01242
OAAI
Menezes, Shinelle; Melandri, Daisy; Anselmi, Giorgio; Perchet, Thibaut; Loschko, Jakob; Dubrot, Juan; Patel, Rajen; Gautier, Emmanuel L.; Hugues, Stephanie; Longhi, M. Paula; Henry, Jake Y.; Quezada, Sergio A.; Lauvau, Gregoire; Lennon-Dumenil, Ana-Maria; Gutierrez-Martinez, Enrique; Bessis, Alain; Gomez-Perdiguero, Elisa; Jacome-Galarza, Christian E.; Garner, Hannah; Geissmann, Frederic; Golub, Rachel; Nussenzweig, Michel C.; Guermonprez, Pierre
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

肿瘤浸润性调节性T细胞的Fc依赖性耗竭共同定义了anti-CTLA-4治疗对黑色素瘤的疗效

JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2013-07-291.3K
OAAI
Simpson, Tyler R.; Li, Fubin; Montalvo-Ortiz, Welby; Sepulveda, Manuel A.; Bergerhoff, Katharina; Arce, Frederick; Roddie, Claire; Henry, Jake Y.; Yagita, Hideo; Wolchok, Jedd D.; Peggs, Karl S.; Ravetch, Jeffrey V.; Allison, James P.; Quezada, Sergio A.

研究方向

暂未获取到该数据
S
Sergio A. Quezada
H 指数:79论文数:389被引数:3.6万
D
Daniel Christ
H 指数:41论文数:167被引数:6,562
R
Romain Rouet
H 指数:24论文数:52被引数:2,974
K
Karl S. Peggs
H 指数:84论文数:516被引数:3.2万
A
Anthony D. Kelleher
H 指数:69论文数:462被引数:2.3万
J
Javier Herrero
H 指数:82论文数:302被引数:6.5万
G
Gregory J. Walker
H 指数:20论文数:62被引数:3,046
C
Christopher C. Goodnow
H 指数:104论文数:429被引数:4.4万
D
Deborah L. Burnett
H 指数:15论文数:48被引数:1,090
C
Charles Swanton
H 指数:137论文数:1,245被引数:11.0万