Romain Rouet

Garvan Institute of Medical Research

H指数:24

被引数:2,974

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Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies

亲和力成熟赋予6类SARS-CoV-2广谱中和抗体强大的活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-01-020

Mazigi, Ohan; Langley, David B.; Henry, Jake Y.; Burnett, Deborah L.; Sobti, Meghna; Walker, GregoryJ.; Rouet, Romain; Balachandran, Harikrishnan; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Schofield, Peter; Brown, Simon H. J.; Schulz, Sebastian R.; Hoffmann, Markus; Poehlmann, Stefan; Post, Jeffrey; Martinello, Marianne; Kelleher, Anthony; Rawlinson, William D.; Turville, Stuart G.; Bull, Rowena A.; Stewart, Alastair G.; Jaeck, Hans-Martin; Goodnow, Christopher C.; Christ, Daniel

Human genomic DNA is widely interspersed with i-motif structures

人类基因组DNA广泛散布着i-motif结构

EMBO JOURNAL

IF8.3

2024-08-292

OAAI

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response

暂时分辨的蛋白质组学将nidogen-2鉴定为胰腺癌的共靶标，其调节纤维化和治疗反应

SCIENCE ADVANCES

IF12.5

2024-07-052

OAAI

Pereira, Brooke A.; Ritchie, Shona; Chambers, Cecilia R.; Gordon, Katie A.; Magenau, Astrid; Murphy, Kendelle J.; Nobis, Max; Tyma, Victoria M.; Liew, Ying Fei; Lucas, Morghan C.; Naeini, Marjan M.; Barkauskas, Deborah S.; Chacon-Fajardo, Diego; Howell, Anna E.; Parker, Amelia L.; Warren, Sean C.; Reed, Daniel A.; Lee, Victoria; Metcalf, Xanthe L.; Lee, Young Kyung; O'Regan, Luke P.; Zhu, Jessie; Trpceski, Michael; Fontaine, Angela R. M.; Stoehr, Janett; Rouet, Romain; Lin, Xufeng; Chitty, Jessica L.; Porazinski, Sean; Wu, Sunny Z.; Filipe, Elysse C.; Cadell, Antonia L.; Holliday, Holly; Yang, Jessica; Papanicolaou, Michael; Lyons, Ruth J.; Zaratzian, Anaiis; Tayao, Michael; Da Silva, Andrew; Vennin, Claire; Yin, Julia; Dew, Alysha B.; Mcmillan, Paul J.; Goldstein, Leonard D.; Deveson, Ira W.; Croucher, David R.; Samuel, Michael S.; Sim, Hao-Wen; Batten, Marcel; Chantrill, Lorraine; Grimmond, Sean M.; Gill, Anthony J.; Samra, Jaswinder; Evans, Thomas R. Jeffry; Sasaki, Takako; Phan, Tri G.; Swarbrick, Alexander; Sansom, Owen J.; Morton, Jennifer P.; Pajic, Marina; Parker, Benjamin L.; Herrmann, David; Cox, Thomas R.; Timpson, Paul

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

通过基于表位的选择从恢复期患者中广泛中和SARS-CoV-2抗体

NATURE COMMUNICATIONS

IF15.7

2023-02-0819

OAAI

Rouet, Romain; Henry, Jake Y.; Johansen, Matt D.; Sobti, Meghna; Balachandran, Harikrishnan; Langley, David B.; Walker, Gregory J.; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Mazigi, Ohan; Schofield, Peter; Burnett, Deborah L.; Brown, Simon H. J.; Martinello, Marianne; Hudson, Bernard; Gilroy, Nicole; Post, Jeffrey J.; Kelleher, Anthony; Jaeck, Hans-Martin; Goodnow, Christopher C.; Turville, Stuart G.; Rawlinson, William D.; Bull, Rowena A.; Stewart, Alastair G.; Hansbro, Philip M.; Christ, Daniel

High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cells

响应SARS-CoV-2感染的高滴度中和抗体需要RBD特异性CD4 T细胞，包括增殖记忆细胞

FRONTIERS IN IMMUNOLOGY

IF5.9

2022-12-0511

OAAI

Phetsouphanh, Chansavath; Khoo, Weng Hua; Jackson, Katherine; Klemm, Vera; Howe, Annett; Aggarwal, Anupriya; Akerman, Anouschka; Milogiannakis, Vanessa; Stella, Alberto Ospina; Rouet, Romain; Schofield, Peter; Faulks, Megan L. L.; Law, Hannah; Danwilai, Thidarat; Starr, Mitchell; Munier, C. Mee Ling; Christ, Daniel; Singh, Mandeep; Croucher, Peter I. I.; Brilot-Turville, Fabienne; Turville, Stuart; Phan, Tri Giang; Dore, Gregory J.; Darley, David; Cunningham, Philip; Matthews, Gail V. V.; Kelleher, Anthony D. D.; Zaunders, John J. J.

The retroelement Lx9 puts a brake on the immune response to virus infection

Nature

IF48.5

2022-08-100

PRE

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

IMMUNITY

IF26.3

2021-12-0137

OAAI

Burnett, Deborah L.; Jackson, Katherine J. L.; Langley, David B.; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D.; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M.; Singh, Mandeep; Li, Hui; Henry, Jake Y.; Jackson, Jennifer; Stewart, Alastair G.; Witthauer, Franka; Spence, Matthew A.; Hansbro, Nicole G.; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R.; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J.; Rawlinson, William D.; Karl, Rudolfo; Schaefer, Simon; Winkler, Thomas H.; Brink, Robert; Bull, Rowena A.; Hansbro, Philip M.; Jaeck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher C.

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

SCIENCE ADVANCES

IF12.5

2021-09-1712

OAAI

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

MABS

IF7.3

2021-05-2416

OAAI

Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection

CELL REPORTS MEDICINE

IF10.6

2021-04-0154

OAAI

Abayasingam, Arunasingam; Balachandran, Harikrishnan; Agapiou, David; Hammoud, Mohamed; Rodrigo, Chaturaka; Keoshkerian, Elizabeth; Li, Hui; Brasher, Nicholas A.; Christ, Daniel; Rouet, Romain; Burnet, Deborah; Grubor-Bauk, Branka; Rawlinson, William; Turville, Stuart; Aggarwal, Anupriya; Stella, Alberto Ospina; Fichter, Christina; Brilot, Fabienne; Mina, Michael; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Dwyer, Dominic; Sasson, Sarah C.; Tea, Fiona; Pilli, Deepti; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

由胰腺癌细胞p53-status驱动的CAF层次结构通过perlecan创造了一个促转移和化学抗性的环境

NATURE COMMUNICATIONS

IF15.7

2019-08-12184

OAAI

Vennin, Claire; Melenec, Pauline; Rouet, Romain; Nobis, Max; Cazet, Aurelie S.; Murphy, Kendelle J.; Herrmann, David; Reed, Daniel A.; Lucas, Morghan C.; Warren, Sean C.; Elgundi, Zehra; Pinese, Mark; Kalna, Gabriella; Roden, Daniel; Samuel, Monisha; Zaratzian, Anaiis; Grey, Shane T.; Da Silva, Andrew; Leung, Wilfred; Mathivanan, Suresh; Wang, Yingxiao; Braithwaite, Anthony W.; Christ, Daniel; Benda, Ales; Parkin, Ashleigh; Phillips, Phoebe A.; Whitelock, John M.; Gill, Anthony J.; Sansom, Owen J.; Croucher, David R.; Parker, Benjamin L.; Pajic, Marina; Morton, Jennifer P.; Cox, Thomas R.; Timpson, Paul; Johns, Amber L.; Chantrill, Lorraine A.; Chou, Angela; Steinmann, Angela; Arshi, Mehreen; Dwarte, Tanya; Froio, Danielle; Pereira, Brooke; Ritchie, Shona; Chambers, Cecilia R.; Metcalf, Xanthe; Waddell, Nicola; Pearson, John, V; Patch, Ann-Marie; Nones, Katia; Newell, Felicity; Mukhopadhyay, Pamela; Addala, Venkateswar; Kazakoff, Stephen; Holmes, Oliver; Leonard, Conrad; Wood, Scott; Grimmond, Sean M.; Hofmann, Oliver; Christ, Angelika; Bruxner, Tim; Samra, Jaswinder S.; Pavlakis, Nick; High, Hilda A.; Asghari, Ray; Merrett, Neil D.; Pavey, Darren; Das, Amitabha; Cosman, Peter H.; Ismail, Kasim; O'Connnor, Chelsie; Stoita, Alina; Williams, David; Spigellman, Allan; Lam, Vincent W.; McLeod, Duncan; Kirk, Judy; Kench, James G.; Grimison, Peter; Cooper, Caroline L.; Sandroussi, Charbel; Goodwin, Annabel; Mead, R. Scott; Tucker, Katherine; Andrews, Lesley; Texler, Michael; Forest, Cindy; Epari, Krishna P.; Ballal, Mo; Fletcher, David R.; Mukhedkar, Sanjay; Zeps, Nikolajs; Beilin, Maria; Feeney, Kynan; Nguyen, Nan Q.; Ruszkiewicz, Andrew R.; Worthley, Chris; Chen, John; Brooke-Smith, Mark E.; Papangelis, Virginia; Clouston, Andrew D.; Barbour, Andrew P.; O'Rourke, Thomas J.; Fawcett, Jonathan W.; Slater, Kellee; Hatzifotis, Michael; Hodgkinson, Peter; Nikfarjam, Mehrdad; Eshleman, James R.; Hruban, Ralph H.; Wolfgang, Christopher L.; Lawlor, Rita T.; Beghelli, Stefania; Corbo, Vincenzo; Scardoni, Maria; Bassi, Claudio; Biankin, Andrew, V; Dixon, Judith; Jamieson, Nigel B.; Chang, David K.

Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis

ACS CHEMICAL BIOLOGY

IF3.8

2019-02-1920

PREAI

Engineering CRISPR-Cas9 RNA-Protein Complexes for Improved Function and Delivery

CRISPR JOURNAL

IF4

2018-12-0113

PREAI

Optimized CRISPR-Cpf1 system for genome editing in zebrafish

METHODS